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Biosensors
Special Issues
Integrated Biosensing for Point-of-Care Detection
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Integrated Biosensing for Point-of-Care Detection

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 2711

Special Issue Editors

Dr. Krishna Kant

E-Mail Website
Guest Editor
Centro De Investigaciones Biomédicas (CINBIO), Universidade de Vigo, 36310 Vigo, Spain
Interests: microfluidic sensing; electrochemical bio-sensing; point-of-care diagnostics; precision diagnostics; plasmonic sensing; microfluidic devices; lab-on-chip
Special Issues, Collections and Topics in MDPI journals
Dr. Felismina Teixeira Coelho Moreira

E-Mail Website
Guest Editor
BioMark@ISEP, School of Engineering, Polytechnique School of Porto, 4200-072 Porto, Portugal
Interests: biosensor; electrochemical sensor; plastic antibody
Special Issues, Collections and Topics in MDPI journals
Dr. Davesh K. Avasthi

E-Mail Website
Guest Editor
Centre for interdisciplinary Research and Innovation (CIDRI), University of Pertoleum and Energy Studies, Dehradun 248007, India
Interests: electrochemical sensing; biofunctional material; diagnostic; lab-on-chip; molecular bioassay; food safety

Special Issue Information

Dear Colleagues,

Integrated sensing technology is an evolving field with major applications in cell chip model systems, the monitoring of biological activities and on-chip detection in chemical, biological and environmental domains. This Special Issue is devoted to advances in a variety of subjects in this area, from detection, to engineering and integration methods, to innovative sensors. Articles may address current progress in multiplexed detection involving electrochemical, optical, magnetic, and other transduction types.

I am pleased to invite you to contribute an article to this Special Issue, entitled “Integrated Biosensing for Point-of-Care Detection”. The scope of this Special Issue includes, but is not limited to, the following areas:

  • Progress in biosensor approaches and relevance;
  • The innovative technology of chip-based recognition devices;
  • Biomimetic systems and devices for biosensing applications;
  • Biological and chemical substances, incorporating new materials;
  • Lab-on-a-chip-based systems.

Research and review articles addressing current developments in the field, as well as capabilities and technologies relevant to biosensing, will be considered for publication. This Special Issue aims to garner the attention of the scientific community, including researchers in cell culture and molecular diagnostics, chemists and doctors, etc.

Dr. Krishna Kant
Dr. Felismina Teixeira Coelho Moreira
Dr. Davesh K. Avasthi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnostics
  • molecular imprinted polymer biosensing
  • multiplexed biosensing
  • bio-inspired materials
  • cell and tissue sensors

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  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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17 pages, 9476 KiB  
Article
Portable Amperometric Biosensor Enhanced with Enzyme-Ternary Nanocomposites for Prostate Cancer Biomarker Detection
by Thenmozhi Rajarathinam, Sivaguru Jayaraman, Chang-Seok Kim, Jaewon Lee and Seung-Cheol Chang
Biosensors 2024, 14(12), 623; https://doi.org/10.3390/bios14120623 - 18 Dec 2024
Viewed by 1040
Abstract
Enzyme-based portable amperometric biosensors are precise and low-cost medical devices used for rapid cancer biomarker screening. Sarcosine (Sar) is an ideal biomarker for prostate cancer (PCa). Because human serum and urine contain complex interfering substances that can directly oxidize at the electrode surface, [...] Read more.
Enzyme-based portable amperometric biosensors are precise and low-cost medical devices used for rapid cancer biomarker screening. Sarcosine (Sar) is an ideal biomarker for prostate cancer (PCa). Because human serum and urine contain complex interfering substances that can directly oxidize at the electrode surface, rapid Sar screening biosensors are relatively challenging and have rarely been reported. Therefore, highly sensitive and selective amperometric biosensors that enable real-time measurements within <1.0 min are needed. To achieve this, a chitosan–polyaniline polymer nanocomposite (CS–PANI NC), a carrier for dispersing mesoporous carbon (MC), was synthesized and modified on a screen-printed carbon electrode (SPCE) to detect hydrogen peroxide (H2O2). The sarcosine oxidase (SOx) enzyme-immobilized CS–PANI–MC-2 ternary NCs were referred to as supramolecular architectures (SMAs). The excellent electron transfer ability of the SMA-modified SPCE (SMA/SPCE) sensor enabled highly sensitive H2O2 detection for immediate trace Sar biomarker detection. Therefore, the system included an SMA/SPCE coupled to a portable potentiostat linked to a smartphone for data acquisition. The high catalytic activity, porous architecture, and sufficient biocompatibility of CS–PANI–MC ternary NCs enabled bioactivity retention and immobilized SOx stability. The fabricated biosensor exhibited a detection limit of 0.077 μM and sensitivity of 8.09 μA mM−1 cm−2 toward Sar, demonstrating great potential for use in rapid PCa screening. Full article
(This article belongs to the Special Issue Integrated Biosensing for Point-of-Care Detection)
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11 pages, 1803 KiB  
Article
Paper-Based Aptasensor Assay for Detection of Food Adulterant Sildenafil
by Murat Kavruk and Veli Cengiz Ozalp
Biosensors 2024, 14(12), 620; https://doi.org/10.3390/bios14120620 - 17 Dec 2024
Viewed by 1113
Abstract
Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension but is often illicitly added to energy drinks and chocolates. This study introduces a lateral flow strip test using aptamers specific to sildenafil for detecting its illegal presence in food. The process [...] Read more.
Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension but is often illicitly added to energy drinks and chocolates. This study introduces a lateral flow strip test using aptamers specific to sildenafil for detecting its illegal presence in food. The process involved using graphene oxide SELEX to identify high-affinity aptamers, which were then converted into molecular gate structures on mesoporous silica nanoparticles, creating a unique signaling system. This system was integrated into lateral flow chromatography strips and tested on buffers and chocolate samples containing sildenafil. The method simplifies the lateral flow assay (LFA) for small molecules and provides a tool for signal amplification. The detection limit for these strips was found to be 68.2 nM (31.8 µg/kg) in spiked food samples. Full article
(This article belongs to the Special Issue Integrated Biosensing for Point-of-Care Detection)
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