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Journal of Functional Biomaterials, Volume 16, Issue 8

August 2025 - 36 articles

Cover Story: Simulated microgravity, achieved through rotating wall vessel bioreactors, provides a unique 3D dynamic culture environment that enhances tissue engineering by mimicking space-like conditions. In bone tissue research, 3D-printed trabecular scaffolds cultured under such conditions show a specific cell response. The absence of sedimentation and the continuous rotation allow uniform cell distribution, improve the delivery of nutrients and oxygen, and facilitate the removal of metabolic waste. Beyond bone, simulated microgravity offers a powerful platform for advancing all tissue engineering fields, enabling more physiologically relevant models and accelerating biomedical innovation to support space medicine. View this paper
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Articles (36)

  • Article
  • Open Access
1 Citations
1,469 Views
16 Pages

Ultrasound-Responsive Drug Delivery System Based on Piezoelectric Catalytic Mechanisms

  • Kaixi Cui,
  • Tianzheng Li,
  • Yifei Ma,
  • Chuanjin Zhang,
  • Ke Zhang,
  • Chao Qi and
  • Kaiyong Cai

Ultrasound-responsive nanomaterials represent a promising approach for achieving non-invasive and localized drug delivery within tumor microenvironments. In this study, we developed a piezocatalysis-assisted hydrogel system that integrates reactive o...

  • Article
  • Open Access
815 Views
24 Pages

Hydrothermal Magnesium Alloy Extracts Modulate MicroRNA Expression in RAW264.7 Cells: Implications for Bone Remodeling

  • Viviana Costa,
  • Lavinia Raimondi,
  • Daniele Bellavia,
  • Angela De Luca,
  • Pasquale Guglielmi,
  • Angela Cusanno,
  • Luca Cattini,
  • Lia Pulsatelli,
  • Matteo Pavarini and
  • Roberto Chiesa
  • + 1 author

Magnesium (Mg) alloys, particularly Mg AZ31, have emerged as promising biomaterials for orthopedic applications due to their biodegradability and favorable mechanical characteristics. Among these, the Mg AZ31+SPF alloy, subjected to hydrothermal (HT)...

  • Article
  • Open Access
1 Citations
1,121 Views
17 Pages

Enhanced Osteogenic Response to an Osteochondral Scaffold Modified with BMP-2 or Strontium-Enriched Amorphous Calcium Phosphate in a Co-Culture In Vitro Model

  • Stefania Pagani,
  • Manuela Salerno,
  • Janis Locs,
  • Jana Vecstaudza,
  • Laura Dolcini,
  • Milena Fini,
  • Gianluca Giavaresi,
  • Giuseppe Filardo and
  • Marta Columbaro

Background: A trilayered collagen/collagen–magnesium–hydroxyapatite (Col/Col-Mg-HA) scaffold is used in clinical practice to treat osteochondral lesions, but the regeneration of the subchondral bone is still not satisfactory. Objective: T...

  • Article
  • Open Access
874 Views
14 Pages

Comparative in Vitro Evaluation of Marginal Sealing in Class I Composite Restorations Using Fifth- and Seventh-Generation Adhesives

  • Serban Talpos Niculescu,
  • Ioana Veja,
  • George-Dumitru Constantin,
  • Ioana Elena Lile,
  • Christos Armeniakos,
  • Ioana Roxana Munteanu and
  • Tareq Hajaj

Background: A major challenge in adhesive dentistry, often leading to restoration failure, is microleakage. This in vitro comparative study was designed to assess microleakage at the tooth–composite interface. The investigation aimed to compare...

  • Article
  • Open Access
852 Views
23 Pages

Composite scaffolds based on a hydrogel matrix modified with hydroxyapatite, magnesium, or zinc compounds are promising for filling and regenerating osteochondral defects due to the specific biological properties of these modifiers. The aim of this w...

  • Article
  • Open Access
900 Views
12 Pages

Antibacterial Characteristics of Nanoclay-Infused Cavit Temporary Filling Material: In Vitro Study

  • Bahareh Nazemi Salman,
  • Ayda Notash,
  • Ali Ramazani,
  • Shaghayegh Niaz,
  • Seyed Mohammadrasoul Naeimi,
  • Shayan Darvish and
  • Ionut Luchian

In pediatric endodontic procedures, final crown placement is often delayed, requiring the use of temporary filling materials to seal the access cavity. Given the importance of antibacterial properties in temporary restorations and the known antimicro...

  • Article
  • Open Access
743 Views
22 Pages

Biliary Injuries Repair Using Copolymeric Scaffold: A Systematic Review and In Vivo Experimental Study

  • Salvatore Buscemi,
  • Giulia Bonventre,
  • Andrea Gottardo,
  • Mariano Licciardi,
  • Fabio Salvatore Palumbo,
  • Giovanni Cassata,
  • Luca Cicero,
  • Giulia Lo Monte,
  • Roberto Puleio and
  • Attilio Ignazio Lo Monte

Background: Common bile duct (CBD) treatments are often associated with complications, limiting long-term efficacy. To overcome these issues, polymeric grafts have been suggested as promising alternatives, since they are highly customizable, biocompa...

  • Article
  • Open Access
1,489 Views
18 Pages

Influence of Drilling Protocol on Primary Implant Stability Depending on Different Bone Qualities and Implant Macro-Designs, Lengths, and Diameters

  • Milan Stoilov,
  • Ramin Shafaghi,
  • Lea Stoilov,
  • Helmut Stark,
  • Michael Marder,
  • Norbert Enkling and
  • Dominik Kraus

Background: Primary implant stability is a critical factor for successful osseointegration and long-term implant success. This study investigates the impact of drilling protocol modifications on primary stability, considering different bone qualities...

  • Article
  • Open Access
1,038 Views
21 Pages

MIL-53 MOF on Sustainable Biomaterial for Antimicrobial Evaluation Against E. coli and S. aureus Bacteria by Efficient Release of Penicillin G

  • Delia Monserrat Ávila-Márquez,
  • Alien Blanco Flores,
  • Helen Paola Toledo Jaldin,
  • Mateo Burke Irazoque,
  • Maribel González Torres,
  • Alfredo Rafael Vilchis-Nestor,
  • Carla Calderon Toledo,
  • Sergio Gutiérrez-Cortez,
  • Juan Pablo Díaz Rodríguez and
  • Alejandro Dorazco-González

The development of efficient antibiotic-releasing materials derived from sustainable and recyclable compounds represents a key area within biomedical materials science, particularly in the treatment of antibacterial infections. Herein, a Fe3+/terepht...

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J. Funct. Biomater. - ISSN 2079-4983