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Bio-Additive Manufacturing in Materials Science
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Bio-Additive Manufacturing in Materials Science

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials and Devices for Healthcare Applications".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 2521

Special Issue Editors

Dr. Vito Gallicchio

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Guest Editor
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, via S. Pansini 5, 80131 Naples, Italy
Interests: additive manufacturing design; finite element analysis; mechanical measurements and mechanics of materials; design methods; dental materials; scaffold design for tissue engineering; prosthesis design
Dr. Ida Papallo

E-Mail Website
Guest Editor
Department of Industrial Engineering, Fraunhofer JL IDEAS, University of Naples Federico II, P.le Tecchio 80, 80125 Naples, Italy
Interests: additive manufacturing design; finite element analysis; mechanical measurements and mechanics of materials; design methods; generative design; scaffold design for tissue engineering; prosthesis design
Dr. Roberto De Santis

E-Mail Website
Guest Editor
Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, V.le J.F. Kennedy 54, Mostra d’Oltremare Pad. 20, 80125 Naples, Italy
Interests: polymer-based composites; nanocomposites; additive manufacturing; fused deposition modeling; stereolithography; finite element analysis; bone; dentine; scaffolds; prostheses
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is already reported that additive manufacturing facilitates the development of devices with complex shapes/architectures, as well as tailored mechanical, functional and biological properties, for several biomedical applications.

In this context, additive manufacturing design and the material–design relationship play a crucial role in the development of advanced prostheses and 3D porous scaffolds for tissue engineering.

Accordingly, in the current Special Issue, we invite authors to submit papers with the aim of providing a complete view of current progress in this realm.

With a focus on “Bio-Additive Manufacturing in Materials Science”, potential topics include, but are not limited to, the following:

  • Additive manufacturing design;
  • Three-dimensional/four-dimensional printing;
  • Reverse engineering;
  • Modeling and simulation;
  • Artificial intelligence methods;
  • Biomimetics and bioinspiration;
  • Prosthesis and scaffold design for tissue engineering.

Dr. Vito Gallicchio
Dr. Ida Papallo
Prof. Dr. Roberto De Santis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • design for additive manufacturing
  • three-dimensional/four-dimensional printing
  • reverse engineering
  • modeling and simulation
  • artificial intelligence methods
  • biomimetics and bioinspiration
  • prosthesis and scaffold design for tissue engineering

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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36 pages, 17913 KiB  
Article
Manufacturing, Microstructure, and Mechanics of 316L SS Biomaterials by Laser Powder Bed Fusion
by Zhizhou Zhang, Paul Mativenga and Shi-Qing Huang
J. Funct. Biomater. 2025, 16(8), 280; https://doi.org/10.3390/jfb16080280 - 31 Jul 2025
Viewed by 517
Abstract
Laser powder bed fusion (LPBF) is an advanced additive manufacturing technology that is gaining increasing interest for biomedical implants because it can produce dense, patient-specific metallic components with controlled microstructures. This study investigated the LPBF fabrication of 316L stainless steel, which is widely [...] Read more.
Laser powder bed fusion (LPBF) is an advanced additive manufacturing technology that is gaining increasing interest for biomedical implants because it can produce dense, patient-specific metallic components with controlled microstructures. This study investigated the LPBF fabrication of 316L stainless steel, which is widely used in orthopedic and dental implants, and examined the effects of laser power and scanning speed on the microstructure and mechanical properties relevant to biomedical applications. The study achieved 99.97% density and refined columnar and cellular austenitic grains, with optimized molten pool morphology. The optimal LPBF parameters, 190 W laser power and 700 mm/s, produced a tensile strength of 762.83 MPa and hardness of 253.07 HV0.2, which exceeded the values of conventional cast 316L stainless steel. These results demonstrated the potential of optimized LPBF 316L stainless steel for functional biomedical applications that require high mechanical integrity and biocompatibility. Full article
(This article belongs to the Special Issue Bio-Additive Manufacturing in Materials Science)
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15 pages, 2263 KiB  
Article
Comparison of the Trueness of Complete Dentures Fabricated Using Liquid Crystal Display 3D Printing According to Build Angle and Natural Light Exposure
by Haeri Kim, KeunBaDa Son, So-Yeun Kim and Kyu-Bok Lee
J. Funct. Biomater. 2025, 16(8), 277; https://doi.org/10.3390/jfb16080277 - 30 Jul 2025
Viewed by 597
Abstract
The dimensional accuracy of the intaglio surface of complete dentures fabricated using liquid crystal display (LCD) three-dimensional (3D) printing might be influenced by the build angle and post-processing storage conditions. This study evaluated the effect of build angle and natural light exposure duration [...] Read more.
The dimensional accuracy of the intaglio surface of complete dentures fabricated using liquid crystal display (LCD) three-dimensional (3D) printing might be influenced by the build angle and post-processing storage conditions. This study evaluated the effect of build angle and natural light exposure duration on the intaglio surface trueness of maxillary complete denture bases. Standardized denture base designs (2 mm uniform thickness) were fabricated using an LCD 3D printer (Lilivis Print; Huvitz, Seoul, Republic of Korea) at build angles of 0°, 45°, and 90° (n = 7 per group). All specimens were printed using the same photopolymer resin (Tera Harz Denture; Graphy, Seoul, Republic of Korea) and identical printing parameters, followed by ultrasonic cleaning and ultraviolet post-curing. Specimens were stored under controlled light-emitting diode lighting and exposed to natural light (400–800 lux) for 0, 14, or 30 days. The intaglio surfaces were scanned and superimposed on the original design data, following the International Organization for Standardization 12836. Quantitative assessment included root mean square deviation, mean deviation, and tolerance percentage. Statistical analyses were performed using one-way analysis of variance and paired t-tests (α = 0.05). Build angle and light exposure duration significantly affected surface trueness (p < 0.05). The 90° build angle group exhibited the highest accuracy and dimensional stability, while the 0° group showed the greatest deviations (p < 0.05). These findings underscore the importance of optimizing build orientation and storage conditions in denture 3D printing. Full article
(This article belongs to the Special Issue Bio-Additive Manufacturing in Materials Science)
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20 pages, 20541 KiB  
Article
Influence of Stent Structure on Mechanical and Degradation Properties of Poly (Lactic Acid) Vascular Stent
by Shicheng He, Qiang Chen and Zhiyong Li
J. Funct. Biomater. 2025, 16(7), 248; https://doi.org/10.3390/jfb16070248 - 6 Jul 2025
Viewed by 702
Abstract
Biodegradable vascular stents (BVSs) face challenges related to inadequate mechanical strength, which can lead to adverse clinical outcomes. Improving the mechanical behavior of biodegradable vascular stents through structural design has been extensively explored. However, the corresponding effects of these mechanical enhancements on degradation [...] Read more.
Biodegradable vascular stents (BVSs) face challenges related to inadequate mechanical strength, which can lead to adverse clinical outcomes. Improving the mechanical behavior of biodegradable vascular stents through structural design has been extensively explored. However, the corresponding effects of these mechanical enhancements on degradation characteristics remain under-investigated. The present work focuses on examining how different stent design strategies affect the mechanical behavior and degradation characteristics of poly (lactic acid) (PLA) stents. The commercial PLA stent DESolve was adopted, and nine modified stents were constructed based on the geometrical configuration of the DESolve stent. The mechanical properties of the modified stents during radial crimping and three-point bending simulations were thoroughly studied. The degradation dynamics of the stents were characterized by four indices (i.e., mean number average molecular weight, residual volume fraction, mean von Mises stress, and stent diameter). The results indicated that both the widening ratio and direction affected the mechanical performance of the stents by increasing the radial stiffness and radial strength, minimizing recoil%, and decreasing the bending flexibility. Although the widening direction had a relatively minor influence on stent degradation, the associated increase in material volume contributed to an improved volumetric integrity and enhanced lumen preservation. This study established a theoretical basis for evaluating both the mechanical and degradation behaviors of PLA stents, offering valuable insights for future structural design optimization. Full article
(This article belongs to the Special Issue Bio-Additive Manufacturing in Materials Science)
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