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Molecular Mechanisms and Biological Procedures of Biomaterials in Medical Applications...
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Molecular Mechanisms and Biological Procedures of Biomaterials in Medical Applications (2nd Edition)

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials and Devices for Healthcare Applications".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 4369

Editors

Dr. Yi Zhang

E-Mail Website
Guest Editor
School of Minerals Processing and Bioengineering, Central South University, Changsha, China
Interests: biomaterials; bio–nano interaction; molecular mechanisms; biological procedures; medical applications
Special Issues, Collections and Topics in MDPI journals
Dr. Lu Xia

E-Mail Website
Guest Editor
School of Life Sciences, Central South University, Changsha 410078, China
Interests: biomaterials; bioinformatics; genetics; molecular mechanisms; medical applications

Special Issue Information

Dear Colleagues,

Biomaterials have emerged as a potentially powerful paradigm in clinical medicine, owing to their unique physicochemical properties such as topographical cues, charges, and so on. Numerous efforts have been made to explore processing methods to tailored nanomaterials for medical applications, including regenerative medicine, therapeutic delivery, and additive manufacturing. Intriguingly, many studies have identified the existence of bio–nano interaction, which plays important roles in biological procedures. Furthermore, biomaterials with diverse physical and/or chemical characteristics induce different biological effects, but their detailed mechanisms remain unclear.

The translational application of biomaterials for clinical medicine is still expanding. The molecular mechanisms and biological procedures employing biomaterials in medical applications include technologies for processing biomaterials; techniques for characterizing physiochemical properties and analyzing bio–nano interaction, biological behaviors, and mechanisms; and indications for medical applications, among others.

The Special Issue of the Journal of Functional Biomaterials, titled “Molecular mechanisms and biological procedures of biomaterials in medical applications (2nd Edition)”, aims to collect articles exploring biological procedures induced by biomaterials, interactions between biomaterials and biological cells, and medical applications of biomaterials, among others.

Dr. Yi Zhang
Dr. Lu Xia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • bio–nano interaction
  • molecular mechanisms
  • biological procedures
  • bioinformatics
  • genetics
  • medical applications

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Related Special Issue

Published Papers (3 papers)

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Research

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20 pages, 18842 KB  
Article
Fibrinogen Adsorption and Sponge-like Aggregate Formation on Titanium Modified by Electrochemically Deposited CaCO3
by Zubair Ahmed and Huiliang Cao
J. Funct. Biomater. 2026, 17(8), 366; https://doi.org/10.3390/jfb17080366 - 30 Jul 2026
Viewed by 275
Abstract
Fibrinogen adsorption governs biological responses to implantable medical devices; however, surface properties influence the overall functionality of the biomaterial, and guided fibrinogen adsorption remains limited. In the present work, CaCO3 was electrochemically deposited on commercial Ti at −1.6 V for 1 h, [...] Read more.
Fibrinogen adsorption governs biological responses to implantable medical devices; however, surface properties influence the overall functionality of the biomaterial, and guided fibrinogen adsorption remains limited. In the present work, CaCO3 was electrochemically deposited on commercial Ti at −1.6 V for 1 h, 2 h, and 3 h. Furthermore, the effects on fibrinogen adsorption were detailed by using dye-assisted scanning electron microscopy (d-SEM), X-ray photoelectron spectroscopy (XPS), and Fourier Transform Infrared Spectroscopy (ATR-FTIR). Longer deposition times produced thicker calcite layers with maximum surface coverage of 99.80 ± 0.40%, accompanied by progressively greater calcium-ion release, ranging from 3.5 mg·L−1·cm−2 (1 h) to 12.2 mg·L−1·cm−2 (3 h) over 240 min. The results show that electrochemically deposited calcite crystals for 3 h lead to the formation of sponge-like fibrinogen aggregates via calcium ion-mediated conformational activation, particularly by chelating with the histidine and carboxylate residues of the Bβ chain segment Gly-His-Arg-Pro (β15–β18). This structural reorganization was supported by XPS N 1s binding energy at 398.80 eV and a red shift in Amide I and Amide II bands in FTIR spectra. Overall, this study reveals that careful modification of surface chemistry can guide fibrinogen adsorption, which can be beneficial for advanced biomaterials to orchestrate tissue integration at the protein and cellular levels. Full article
(This article belongs to the Special Issue Molecular Mechanisms and Biological Procedures of Biomaterials in Medical Applications (2nd Edition))
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Review

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22 pages, 8914 KB  
Review
Polyphosphate in Bone Tissue Engineering: From Molecular Mechanisms to Material Design
by Zhangling Nie, Bingqiang Lu, Valentina K. Krut’ko, Anatoly I. Kulak and Feng Chen
J. Funct. Biomater. 2026, 17(8), 422; https://doi.org/10.3390/jfb17080422 - 21 Aug 2026
Viewed by 221
Abstract
Polyphosphate (PolyP) is an inorganic polymer composed of orthophosphate units linked by high-energy phosphate anhydride bonds, widely found in various organisms from bacteria to mammals. In recent years, PolyP has attracted widespread attention in the field of bone tissue engineering due to its [...] Read more.
Polyphosphate (PolyP) is an inorganic polymer composed of orthophosphate units linked by high-energy phosphate anhydride bonds, widely found in various organisms from bacteria to mammals. In recent years, PolyP has attracted widespread attention in the field of bone tissue engineering due to its unique biological characteristics, possessing both osteoinductive activity and metabolic energy supply functions. This article systematically reviews the molecular structure, physicochemical properties, and multiple mechanisms by which PolyP promotes osteogenic differentiation, as well as biomaterial design strategies based on PolyP. PolyP can synergistically promote osteogenic differentiation through multiple mechanisms, including by acting as a phosphate donor, providing metabolic energy, regulating signaling pathways such as Wnt/β-catenin, and modulating the osteoprotegerin/receptor activator of nuclear factor κB ligand (OPG/RANKL) balance. In terms of material design, PolyP can form nano/microparticles with metal ions such as Ca2+, Sr2+, and Mg2+ and can also be compounded with polymers to construct various forms such as hydrogels, bone cement, and three-dimensional (3D)-printed scaffolds. Preclinical studies have shown that PolyP-incorporated materials exhibit excellent osteogenic performance and biocompatibility in bone defect repair, and preliminary clinical studies have also confirmed its feasibility. This article aims to provide a comprehensive overview of the current applications of PolyP-incorporated materials and delineate future directions, challenges, and necessary pathways for their clinical translation. Full article
(This article belongs to the Special Issue Molecular Mechanisms and Biological Procedures of Biomaterials in Medical Applications (2nd Edition))
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36 pages, 2272 KB  
Review
Bio-Functional Nanomaterials for Enhanced Lung Cancer Therapy: The Synergistic Roles of Vitamins D and K
by Andreea Crintea, Camelia Munteanu, Tamás Ilyés, Ciprian N. Silaghi and Alexandra M. Crăciun
J. Funct. Biomater. 2025, 16(9), 352; https://doi.org/10.3390/jfb16090352 - 19 Sep 2025
Cited by 3 | Viewed by 2540
Abstract
Lung cancer remains a leading cause of cancer-related mortality worldwide, requiring the development of innovative and effective therapeutic strategies. Bio-functional nanomaterials, due to their unique physicochemical properties, offer a versatile platform for targeted drug delivery, controlled release, and multimodal therapies, thereby enhancing efficacy [...] Read more.
Lung cancer remains a leading cause of cancer-related mortality worldwide, requiring the development of innovative and effective therapeutic strategies. Bio-functional nanomaterials, due to their unique physicochemical properties, offer a versatile platform for targeted drug delivery, controlled release, and multimodal therapies, thereby enhancing efficacy and reducing the systemic toxicity of conventional treatments. Independently, both vitamin D and vitamin K have demonstrated significant anti-cancer properties, including inhibition of proliferation, induction of apoptosis, modulation of angiogenesis, and attenuation of metastatic potential in various cancer cell lines and in vivo models. However, their clinical application is often limited by poor bioavailability, rapid metabolism, and potential for off-target effects. Specifically, by enhancing the solubility, stability, and targeted accumulation of fat-soluble vitamins D and K within tumoral tissues for improved lung cancer therapy, this review emphasizes the novel and cooperative role of bio-functional nanomaterials in overcoming these limitations. Future studies should focus on the logical development of sophisticated nanomaterial carriers for optimal co-delivery plans and thorough in vivo validation, aiming to convert these encouraging preclinical results into successful clinical treatments for patients with lung cancer. Full article
(This article belongs to the Special Issue Molecular Mechanisms and Biological Procedures of Biomaterials in Medical Applications (2nd Edition))
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