Molecular Mechanisms and Biological Procedures of Biomaterials in Medical Applications (2nd Edition)

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials and Devices for Healthcare Applications".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1173

Special Issue Editors

School of Minerals Processing and Bioengineering, Central South University, Changsha, China
Interests: biomaterials; bio–nano interaction; molecular mechanisms; biological procedures; medical applications
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Guest Editor
School of Life Sciences, Central South University, Changsha 410078, China
Interests: biomaterials; bioinformatics; genetics; molecular mechanisms; medical applications

Special Issue Information

Dear Colleagues,

Biomaterials have emerged as a potentially powerful paradigm in clinical medicine, owing to their unique physicochemical properties such as topographical cues, charges, and so on. Numerous efforts have been made to explore processing methods to tailored nanomaterials for medical applications, including regenerative medicine, therapeutic delivery, and additive manufacturing. Intriguingly, many studies have identified the existence of bio–nano interaction, which plays important roles in biological procedures. Furthermore, biomaterials with diverse physical and/or chemical characteristics induce different biological effects, but their detailed mechanisms remain unclear.

The translational application of biomaterials for clinical medicine is still expanding. The molecular mechanisms and biological procedures employing biomaterials in medical applications include technologies for processing biomaterials; techniques for characterizing physiochemical properties and analyzing bio–nano interaction, biological behaviors, and mechanisms; and indications for medical applications, among others.

The Special Issue of the Journal of Functional Biomaterials, titled “Molecular mechanisms and biological procedures of biomaterials in medical applications (2nd Edition)”, aims to collect articles exploring biological procedures induced by biomaterials, interactions between biomaterials and biological cells, and medical applications of biomaterials, among others.

Dr. Yi Zhang
Dr. Lu Xia
Guest Editors

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Keywords

  • biomaterials
  • bio–nano interaction
  • molecular mechanisms
  • biological procedures
  • bioinformatics
  • genetics
  • medical applications

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Published Papers (1 paper)

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Review

36 pages, 2272 KB  
Review
Bio-Functional Nanomaterials for Enhanced Lung Cancer Therapy: The Synergistic Roles of Vitamins D and K
by Andreea Crintea, Camelia Munteanu, Tamás Ilyés, Ciprian N. Silaghi and Alexandra M. Crăciun
J. Funct. Biomater. 2025, 16(9), 352; https://doi.org/10.3390/jfb16090352 - 19 Sep 2025
Viewed by 656
Abstract
Lung cancer remains a leading cause of cancer-related mortality worldwide, requiring the development of innovative and effective therapeutic strategies. Bio-functional nanomaterials, due to their unique physicochemical properties, offer a versatile platform for targeted drug delivery, controlled release, and multimodal therapies, thereby enhancing efficacy [...] Read more.
Lung cancer remains a leading cause of cancer-related mortality worldwide, requiring the development of innovative and effective therapeutic strategies. Bio-functional nanomaterials, due to their unique physicochemical properties, offer a versatile platform for targeted drug delivery, controlled release, and multimodal therapies, thereby enhancing efficacy and reducing the systemic toxicity of conventional treatments. Independently, both vitamin D and vitamin K have demonstrated significant anti-cancer properties, including inhibition of proliferation, induction of apoptosis, modulation of angiogenesis, and attenuation of metastatic potential in various cancer cell lines and in vivo models. However, their clinical application is often limited by poor bioavailability, rapid metabolism, and potential for off-target effects. Specifically, by enhancing the solubility, stability, and targeted accumulation of fat-soluble vitamins D and K within tumoral tissues for improved lung cancer therapy, this review emphasizes the novel and cooperative role of bio-functional nanomaterials in overcoming these limitations. Future studies should focus on the logical development of sophisticated nanomaterial carriers for optimal co-delivery plans and thorough in vivo validation, aiming to convert these encouraging preclinical results into successful clinical treatments for patients with lung cancer. Full article
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