Journal of Functional Biomaterials, Volume 16, Issue 10
2025 October - 38 articles
Cover Story: Bone regeneration relies on the balance between osteoblast-mediated bone formation and osteoclast-driven resorption, governed by complex biochemical cues. Magnesium ions (Mg2+) critically regulate these processes, yet their dual influence on osteogenesis and osteoclastogenesis remains unclear. In this study, Mg2+ exhibited dose-dependent effects in 2D culture, with moderate concentrations suppressing osteoclast maturation while limiting osteogenic differentiation. Incorporating Mg2+ into collagen/nano-hydroxyapatite (Coll/nHA) scaffolds enabled localized delivery, revealing synergistic Mg2+–nHA interactions that enhanced bone matrix deposition and reduced osteoclast activity, offering a promising strategy for advanced bone tissue engineering. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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