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Journal of Functional Biomaterials, Volume 16, Issue 10

October 2025 - 38 articles

Cover Story: Bone regeneration relies on the balance between osteoblast-mediated bone formation and osteoclast-driven resorption, governed by complex biochemical cues. Magnesium ions (Mg2+) critically regulate these processes, yet their dual influence on osteogenesis and osteoclastogenesis remains unclear. In this study, Mg2+ exhibited dose-dependent effects in 2D culture, with moderate concentrations suppressing osteoclast maturation while limiting osteogenic differentiation. Incorporating Mg2+ into collagen/nano-hydroxyapatite (Coll/nHA) scaffolds enabled localized delivery, revealing synergistic Mg2+–nHA interactions that enhanced bone matrix deposition and reduced osteoclast activity, offering a promising strategy for advanced bone tissue engineering. View this paper
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Articles (38)

  • Article
  • Open Access
1,088 Views
20 Pages

Experimental Biomechanical Analysis of the Bone-to-Implant Connection in Single-Piece Implants

  • Karina Krawiec,
  • Adam Kurzawa,
  • Jakub J. Słowiński,
  • Calin Romulus Fodor and
  • Łukasz Pałka

19 October 2025

The mechanical properties of dental implants are critical for their durability. The purpose of this study was to determine the maximum force required to induce full pull-out of a titanium implant from the bone and to characterize the mechanical behav...

  • Article
  • Open Access
883 Views
19 Pages

Biological Characterization of 3D-Printed, Sintered Hydroxyapatite Scaffolds Obtained by Fused Filament Fabrication: An In Vitro Study

  • Eddy Shan,
  • Cristina Chamorro,
  • Ana Ferrández-Montero,
  • Rosa M. Martin-Rodriguez,
  • Leire Virto,
  • María José Marín,
  • Begoña Ferrari,
  • Antonio Javier Sanchez-Herencia,
  • Elena Figuero and
  • Mariano Sanz

19 October 2025

This study characterized the biological response of MG-63 cells to synthetic, hydroxyapatite scaffolds (HAsint) fabricated via fused filament fabrication. Scaffolds were compared to 2D plate-adherent cultures using six assays: cell morphology and dis...

  • Article
  • Open Access
738 Views
20 Pages

Strength–Ductility Synergy in Biodegradable Mg-Rare Earth Alloy Processed via Multi-Directional Forging

  • Faseeulla Khan Mohammad,
  • Uzwalkiran Rokkala,
  • Sohail M. A. K. Mohammed,
  • Hussain Altammar,
  • Syed Quadir Moinuddin and
  • Raffi Mohammed

18 October 2025

In this study, a biodegradable Mg-Zn-Nd-Gd alloy was processed via multi-directional forging (MDF) to evaluate its microstructural evolution, mechanical performance, and corrosion behavior. Electron backscattered diffraction (EBSD) analysis was condu...

  • Article
  • Open Access
1,401 Views
25 Pages

Developments and Assessments of Crude Tea Saponin-Incorporated Silica Nanoparticles for Their Bioactivity Improvement

  • Tanrada Likitsatian,
  • Pimpisid Koonyosying,
  • Sittiruk Roytrakul,
  • Patcharawan Srisilapanan,
  • Somdet Srichairatanakool and
  • Jetsada Ruangsuriya

17 October 2025

The use of saponins with biosurfactant, antioxidant, anti-inflammatory, and anti-cancer properties is limited by their toxicity and bioavailability. This study focused on the fabrication, characterization, and bioactivity of crude tea saponin (TS) an...

  • Article
  • Open Access
1 Citations
928 Views
14 Pages

Plate Breakage After Mandibular Condylar Fracture Osteosynthesis

  • Marcin Kozakiewicz,
  • Paulina Agier and
  • Paulina Pruszyńska

16 October 2025

Despite the significant ongoing development of fixation materials, plate breakages still occur after osteosynthesis of the mandibular condyles. The aim of this study is to demonstrate the complications caused by fixation material breakages in the hop...

  • Article
  • Open Access
694 Views
14 Pages

Antibacterial PEEK-Ag Surfaces: Development and In Vitro Evaluation Against Staphylococcus aureus and Pseudomonas aeruginosa

  • Flávio Rodrigues,
  • Mariana Fernandes,
  • Filipe Samuel Silva,
  • Óscar Carvalho and
  • Sara Madeira

16 October 2025

In the pursuit of addressing the persistent challenge of bacterial adhesion and biofilm formation in dental care, this study investigates the efficacy of electric current as an alternative strategy, specifically focusing on its application in dental...

  • Article
  • Open Access
773 Views
13 Pages

15 October 2025

This randomized, prospective clinical trial was conducted to compare the effectiveness of the oscillating chitosan brush (OCB) and an air-abrasive device (AAD) in improving clinical outcomes during non-surgical management of peri-implant mucositis. F...

  • Article
  • Open Access
702 Views
16 Pages

Fibronectin- and Bioactive Glass-Modified Alginate Scaffolds Support Limited Primary Cell Proliferation In Vitro yet Demonstrate Effective Host Integration In Vivo

  • Benedetta Guagnini,
  • Andrea Mazzoleni,
  • Adrien Moya,
  • Arnaud Scherberich,
  • Barbara Medagli,
  • Ivan Martin,
  • Davide Porrelli,
  • Manuele G. Muraro and
  • Gianluca Turco

15 October 2025

Alginate-hydroxyapatite (AL) scaffolds modified with fibronectin (FN) or bioactive glass (BGMS10) have recently been characterized for their physicochemical properties and proposed as promising candidates for bone regeneration. Here, we present their...

  • Review
  • Open Access
983 Views
17 Pages

14 October 2025

Impaired bone regeneration and wound healing represent a major clinical and socioeconomic challenge for our aging and multimorbid population. Fracture and wound healing share many common features, with transforming growth factor beta (TGF-β) bei...

  • Review
  • Open Access
1,113 Views
20 Pages

Natural Polymers, Their Modifications and Composites with Synthetic Polymers for Tympanic Membrane Regeneration

  • Roman O. Shaikenov,
  • Polina G. Serbun,
  • Jingran Zhang,
  • Hao Wu,
  • Zuobin Wang,
  • Petr P. Snetkov and
  • Svetlana N. Morozkina

13 October 2025

The perforation of the tympanic membrane is a world-wide clinical problem resulting from trauma or infection and requiring effective regeneration methods. In recent years researchers have focused on natural polymers as promising materials for restori...

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J. Funct. Biomater. - ISSN 2079-4983Creative Common CC BY license