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Journal of Clinical Medicine, Volume 8, Issue 12

December 2019 - 207 articles

Cover Story: The formation of severe scars still represents the result of the closure process of extended and deep skin wounds. To address this issue, different bioengineered skin substitutes have been developed but a general consensus regarding their effectiveness has not been achieved yet. Repaired skin differs from regenerated skin, showing high contracture, loss of sensitivity, impaired pigmentation and absence of cutaneous adnexa (i.e., hair follicles and sweat glands). This leads to significant mobility and aesthetic concerns, making the development of more effective bioengineered skin models a current need. The objective of this review is to determine the limitations of either commercially available or investigational bioengineered skin substitutes and how advanced skin tissue engineering strategies can be improved in order to completely restore skin functions after severe wounds. View this paper.
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Articles (207)

  • Review
  • Open Access
126 Citations
14,767 Views
20 Pages

17 December 2019

Both environmental and genetic factors contribute to relative species abundance and metabolic characteristics of the intestinal microbiota. The intestinal microbiota and accompanying microbial metabolites differ substantially in those who are obese o...

  • Article
  • Open Access
27 Citations
6,411 Views
12 Pages

Effectiveness and Safety of Direct Oral Anticoagulant for Secondary Prevention in Asians with Atrial Fibrillation

  • Jiesuck Park,
  • So-Ryoung Lee,
  • Eue-Keun Choi,
  • Soonil Kwon,
  • Jin-Hyung Jung,
  • Kyung-Do Han,
  • Myung-Jin Cha,
  • Sang-Bae Ko,
  • Seil Oh and
  • Gregory Y. H. Lip

17 December 2019

We investigated the effectiveness and safety of direct oral anticoagulants (DOACs) for secondary prevention in patients with atrial fibrillation (AF), particularly focusing on subgroups of patients with severe, disabling, and recent stroke. Using the...

  • Article
  • Open Access
11 Citations
5,293 Views
15 Pages

Trials of a Fluorescent Endoscopic Video System for Diagnosis and Treatment of the Head and Neck Cancer

  • Dina Farrakhova,
  • Artem Shiryaev,
  • Dmitry Yakovlev,
  • Kanamat Efendiev,
  • Yulia Maklygina,
  • Alexandr Borodkin,
  • Maxim Loschenov,
  • Lina Bezdetnaya,
  • Anastasia Ryabova and
  • Liana Amirkhanova
  • + 6 authors

17 December 2019

This article presents the results of intraoperative fluorescent diagnostics via the endoscopic system for assessing the quality of photodynamic therapy (PDT) of head and neck cancer. The diagnosis and PDT procedures were performed on the five patient...

  • Article
  • Open Access
18 Citations
3,398 Views
12 Pages

Neopterin is Associated with Disease Severity and Outcome in Patients with Non-Ischaemic Heart Failure

  • Lukas Lanser,
  • Gerhard Pölzl,
  • Dietmar Fuchs,
  • Günter Weiss and
  • Katharina Kurz

17 December 2019

Inflammation and immune activation play an important role in the pathogenesis of cardiac remodelling in patients with heart failure. The aim of this study was to assess whether biomarkers of inflammation and immune activation are linked to disease se...

  • Article
  • Open Access
19 Citations
4,458 Views
9 Pages

17 December 2019

We aimed to investigate whether perioperative magnesium sulfate administration was associated with the incidence of chronic persistent postoperative pain (PPP) following total knee arthroplasty (TKA). This retrospective observational study was perfor...

  • Review
  • Open Access
117 Citations
16,205 Views
11 Pages

Type 2 Diabetes Mellitus and Altered Immune System Leading to Susceptibility to Pathogens, Especially Mycobacterium tuberculosis

  • Steve Ferlita,
  • Aram Yegiazaryan,
  • Navid Noori,
  • Gagandeep Lal,
  • Timothy Nguyen,
  • Kimberly To and
  • Vishwanath Venketaraman

16 December 2019

There has been an alarming increase in the incidence of Type 2 Diabetes Mellitus (T2DM) worldwide. Uncontrolled T2DM can lead to alterations in the immune system, increasing the risk of susceptibility to infections such as Mycobacterium tuberculosis...

  • Review
  • Open Access
67 Citations
7,284 Views
8 Pages

16 December 2019

Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea. However, the success of this treatment is hampered by nonadherence in half of the treated patients. Moreover, in clinical trials, poor adherence reduces...

  • Article
  • Open Access
6 Citations
4,219 Views
9 Pages

Comparison of Postoperative Opioid Consumption and Pain Scores in Primary Versus Repeat Cesarean Delivery in Opioid Naïve Patients

  • Amanda Chao,
  • Ioana Pasca,
  • Matthew Alschuler,
  • Jay Lee,
  • Michelle Woodfin,
  • Justin Pugh,
  • Briahnna Austin,
  • Mark Ringer and
  • Davinder Ramsingh

16 December 2019

Background: Cesarean deliveries represent a large percentage of deliveries worldwide. Patients undergoing repeat cesarean deliveries are known to have increased risks for surgical complications. However, little is known regarding potential difference...

  • Article
  • Open Access
9 Citations
4,421 Views
11 Pages

Delayed Occurrence of Hypertrophic Olivary Degeneration after Therapy of Posterior Fossa Tumors: A Single Institution Retrospective Analysis

  • Martin A. Schaller-Paule,
  • Christian Foerch,
  • Sara Kluge,
  • Peter Baumgarten,
  • Jürgen Konczalla,
  • Joachim P. Steinbach,
  • Marlies Wagner and
  • Anna-Luisa Luger

16 December 2019

(1) Background: A lesion within the dentato-rubro-olivary pathway (DROP) in the posterior fossa can cause secondary neurodegeneration of the inferior olivary nucleus: so-called hypertrophic olivary degeneration (HOD). The clinical syndrome of HOD occ...

  • Article
  • Open Access
17 Citations
5,312 Views
16 Pages

Influence of Biologically Oriented Preparation Technique on Peri-Implant Tissues; Prospective Randomized Clinical Trial with Three-Year Follow-Up. Part II: Soft Tissues

  • Rubén Agustín-Panadero,
  • Naia Bustamante-Hernández,
  • Carlos Labaig-Rueda,
  • Antonio Fons-Font,
  • Lucía Fernández-Estevan and
  • María Fernanda Solá-Ruíz

16 December 2019

Purpose: The objective of this prospective randomized clinical trial (RCT) was to analyze and compare the clinical behavior of three types of prosthesis supported by single implants in the posterior region after three years of functional loading. Mat...

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J. Clin. Med. - ISSN 2077-0383