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Open AccessArticle

Trials of a Fluorescent Endoscopic Video System for Diagnosis and Treatment of the Head and Neck Cancer

1
Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia
2
University Clinical Hospital no. 1, Oncology Center, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, 119991 Moscow, Russia
3
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Saratov, Russia
4
Department of Laser Micro-, Nano-, and Biotechnology, Institute of Engineering Physics for Biomedicine, National Research Nuclear University “MEPhI”, 115409 Moscow, Russia
5
Centre de Recherche en Automatique de Nancy, CNRS, Université de Lorraine, 54519 Vandœuvre-lès-Nancy, France
6
Institut de Cancérologie de Lorraine, 54519 Vandoeuvre-lès-Nancy, France
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(12), 2229; https://doi.org/10.3390/jcm8122229
Received: 30 October 2019 / Revised: 9 December 2019 / Accepted: 13 December 2019 / Published: 17 December 2019
(This article belongs to the Section Oncology)
This article presents the results of intraoperative fluorescent diagnostics via the endoscopic system for assessing the quality of photodynamic therapy (PDT) of head and neck cancer. The diagnosis and PDT procedures were performed on the five patients with malignant neoplasms of the vocal cords, lateral surface of the tongue, and trachea and cancer of the left parotid salivary gland. Molecular form of chlorin E6 (Ce6) was intravenously administered with a 1.0–1.1 mg/kg concentration for PDT. Fluorescent diagnostics (FD) was conducted before PDT and after PDT procedures. Control of PDT efficiency was carried out by evaluating the photobleaching of the drug (photosensitizer). The method of intraoperative fluorescent imaging allows determining the exact location of the tumor and its boundaries. The assessment of photosensitizer photobleaching in real time regime allows making quick decisions during PDT procedure, which helps improving the quality of patients’ treatment. The results showed the convenience of endoscopic fluorescent video system in various nosologies of head and neck cancer. Therefore, this diagnostic approach will improve the effectiveness of cancer treatment. View Full-Text
Keywords: fluorescent diagnostics; photodynamic therapy; fluorescent endoscopic video system; fluorescent intraoperative navigation; photosensitizers; chlorin e6; oncological diseases; head and neck cancer fluorescent diagnostics; photodynamic therapy; fluorescent endoscopic video system; fluorescent intraoperative navigation; photosensitizers; chlorin e6; oncological diseases; head and neck cancer
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Farrakhova, D.; Shiryaev, A.; Yakovlev, D.; Efendiev, K.; Maklygina, Y.; Borodkin, A.; Loschenov, M.; Bezdetnaya, L.; Ryabova, A.; Amirkhanova, L.; Samoylova, S.; Rusakov, M.; Zavodnov, V.; Levkin, V.; Reshetov, I.; Loschenov, V. Trials of a Fluorescent Endoscopic Video System for Diagnosis and Treatment of the Head and Neck Cancer. J. Clin. Med. 2019, 8, 2229.

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