Special Issue "Sepsis: Immunopathology, Patient Classification and Clinical Management"
Deadline for manuscript submissions: 15 October 2019
Dr. Brendon P. Scicluna
1. Amsterdam UMC, University of Amsterdam, Center for Experimental Molecular Medicine, Amsterdam Infection and Immunity, Amsterdam, The Netherlands
2. Amsterdam UMC, University of Amsterdam, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam, The Netherlands
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Interests: genomics; immunity; sepsis; infectious diseases; precision medicine; computational biology
Sepsis is a multifaceted syndrome that is understood to be initiated by an abnormal reaction to infection, leading to life-threatening organ dysfunction. Despite empirical antimicrobial therapy and advances in intensive care, it is expected that sepsis will remain a major healthcare problem (it was recently recognized by the World Health Assembly and WHO, who made it a global health priority in 2017). More than 100 clinical trials have evaluated drugs targeting specific components of the host immune response to infection but to no avail. Those failures have been ascribed to the marked heterogeneity in the clinical presentation and immunopathology of sepsis, which hinders the identification of patients who would benefit from specific treatment. For decades, an abnormal inflammatory response to infection was considered to be central to the pathogenesis of sepsis. It is now evident that the host response is altered in a more complex way, involving persistent excessive inflammation, immune suppression, and a failure to restore normal homeostasis. It may be argued that those alterations may reflect a fundamental reorganization of immune and metabolic cell processes; however, it remains difficult to create an overarching framework of the key drivers in sepsis immunopathology versus changes that are secondary and less decisive to patient outcome. Improving our understanding of sepsis pathophysiology is critical for the development of precise therapeutics and patient management. Therefore, this Special Issue is dedicated to advances in sepsis immunopathology, patient classification, and clinical management.
Dr. Brendon P Scicluna
Manuscript Submission Information
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