Special Issue "The Past, Present and Future of Photodynamic Therapy for Cancers"
Deadline for manuscript submissions: closed (15 January 2020).
Interests: targeted photodynamic therapy; targeted nanomedicines; molecular targeted therapies; molecular imaging, theranostics
Interests: photodynamic therapy; dosimetry; optical spectroscopy; image guided surgery; optical diagnosistics; theranostics
Interests: photodynamic therapy; targeted nanomedicines; quantitative molecular imaging; extrinsically-activatable nanotherapeutics; personalized medicine
Photodynamic therapy was introduced more than one hundred years ago as a method that needed three elements to create local toxicity: A light-sensitive chemical, also known as a photosensitizer, light, and oxygen. Since then, many preclinical studies and clinical trials have been conducted showing the great potential of this local cancer therapy, which has also been described to lead to systemic effects through activation of the immune system. Altogether, those studies led to the regulatory approval of PDT as a cancer treatment over thirty years ago. Nonetheless, it is generally accepted that this treatment modality is still underutilized in the clinic. This is for several reasons, among which: a. The complex and variable modes of action of PDT that have yet to be fully exploited in the clinic in order to maximize efficacy; b. the complex dosimetry parameters that can prevent PDT from reaching its fullest potential; and c. the industrial and commercialization challenges faced over these years. Because of these, many aspects are currently being investigated, with the aim of improving the application of PDT in the clinic and rendering it more effective, accessible, and standardized, so that a larger number of cancer patients can benefit from its unique advantages over conventional modalities, such as chemotherapy and radiotherapy.
The present Special Issue aims to address “The Past, Present and Future of PDT” by assembling significant contributions in the following cathegories:
- Crucial past efforts made in this field, especially focusing on the work of Dr. Thomas Dougherty, who passed away on October 2nd 2018;
- Insights into the present applications of PDT in the clinic;
- Current developments focused on improving PDT, such as but not limited to:
- Macromolecular targeting of photosensitizers;
- Nanoparticles as photosensitizers’ delivery vehicles;
- Light delivery and dosimetry;
- Combination of PDT with other therapies;
- Immunological component of PDT;
- Alternatives for hypoxic tumors;
- Perspectives on the future of PDT.
We hope this scope will encourage the participation of many researchers and clinicians, who still believe it is possible to render PDT more effective and more commonly available to patients. Contributions can be made in the format of research articles, reviews, communications, perspectives, opinions, concept papers, and case studies.
Dr. Sabrina Oliveira
Dr. Dominic Robinson
Dr. Girgis Obaid
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Photodynamic therapy