- Article
Rhodospirillum rubrum L-Asparaginase Conjugates with Polyamines of Improved Biocatalytic Properties as a New Promising Drug for the Treatment of Leukemia
- Natalia V. Dobryakova,
- Dmitry D. Zhdanov,
- Nikolay N. Sokolov,
- Svetlana S. Aleksandrova,
- Marina V. Pokrovskaya and
- Elena V. Kudryashova
L-asparaginase Rhodospirillum rubrum (RrA) is an enzyme (amidohydrolases; EC 3.5.1.1) that catalyzes the L-asparagine hydrolysis reaction to form L-aspartic acid. Due to the shortcomings of existing L-asparaginases from Esherichia coli (EcA) and Erwi...

