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Pathogens, Volume 9, Issue 5

May 2020 - 95 articles

Cover Story: Neogi et al. used a combination of bioinformatics and computer-aided drug design and identified four potential nucleoside inhibitors for the treatment of COVID-19: Remdesivir, 5-Fluorouracil, Ribavirin, and Favipiravir. New clinical trials are supporting their results. View this paper
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Articles (95)

  • Review
  • Open Access
57 Citations
8,896 Views
17 Pages

Drug Discovery against Acanthamoeba Infections: Present Knowledge and Unmet Needs

  • Hany M. Elsheikha,
  • Ruqaiyyah Siddiqui and
  • Naveed Ahmed Khan

Although major strides have been made in developing and testing various anti-acanthamoebic drugs, recurrent infections, inadequate treatment outcomes, health complications, and side effects associated with the use of currently available drugs necessi...

  • Article
  • Open Access
10 Citations
4,470 Views
14 Pages

Microbiological and Histological Analysis for the Evaluation of Farmed Mussels (Mytilus galloprovincialis) Health Status, in Coastal Areas of Italy

  • Roberta Battistini,
  • Katia Varello,
  • Valeria Listorti,
  • Michela Zambon,
  • Giuseppe Arcangeli,
  • Elena Bozzetta,
  • Danila Raffaella Francese,
  • Carlo Ercolini and
  • Laura Serracca

Shellfish farming is a relevant economic activity in Italy. The Gulf of La Spezia is one of the major production areas for mussels: the area is characterized by the presence of numerous human activities that could harm the quality of seawater. Additi...

  • Article
  • Open Access
5 Citations
3,582 Views
21 Pages

LC-QTOF-MS and 1H NMR Metabolomics Verifies Potential Use of Greater Omentum for Klebsiella pneumoniae Biofilm Eradication in Rats

  • Joanna Teul,
  • Stanisław Deja,
  • Katarzyna Celińska-Janowicz,
  • Adam Ząbek,
  • Piotr Młynarz,
  • Piotr Barć,
  • Adam Junka,
  • Danuta Smutnicka,
  • Marzenna Bartoszewicz and
  • Jerzy Pałka
  • + 1 author

Bacterial wound infections are a common problem associated with surgical interventions. In particular, biofilm-forming bacteria are hard to eradicate, and alternative methods of treatment based on covering wounds with vascularized flaps of tissue are...

  • Article
  • Open Access
18 Citations
5,123 Views
14 Pages

Both Strongyloides stercoralis and hookworms are common soil-transmitted helminths in remote Australian communities. In addition to infecting humans, S. stercoralis and some species of hookworms infect canids and therefore present both environmental...

  • Article
  • Open Access
11 Citations
4,981 Views
15 Pages

Loaches are widely distributed throughout the natural environment and are consumed for medicinal purposes in East Asia. Usually, loaches are cultured in ponds where the water conditions can easily cause bacterial infections. Infections due to bacteri...

  • Review
  • Open Access
25 Citations
11,375 Views
23 Pages

Vaccinia Virus as a Master of Host Shutoff Induction: Targeting Processes of the Central Dogma and Beyond

  • Pragyesh Dhungel,
  • Fernando M. Cantu,
  • Joshua A. Molina and
  • Zhilong Yang

The synthesis of host cell proteins is adversely inhibited in many virus infections, whereas viral proteins are efficiently synthesized. This phenomenon leads to the accumulation of viral proteins concurrently with a profound decline in global host p...

  • Article
  • Open Access
36 Citations
4,352 Views
9 Pages

Characteristics of Serotype 3 Invasive Pneumococcal Disease before and after Universal Childhood Immunization with PCV13 in Massachusetts

  • Rotem Lapidot,
  • Kimberly M. Shea,
  • Inci Yildirim,
  • Howard J. Cabral,
  • Stephen I. Pelton and
  • the Massachusetts Department of Public Health

Background: Although a substantial decline in vaccine-serotype invasive pneumococcal disease (IPD) incidence was observed following the introduction of pneumococcal conjugate vaccines (PCV), the estimated range of thirteen-valent conjugate vaccine (P...

  • Article
  • Open Access
4 Citations
3,193 Views
7 Pages

Simultaneous Nasal Carriage by Methicillin-Resistant and Methicillin Susceptible Staphylococcus aureus of Lineage ST398 in a Live Pig Transporter

  • Paula Gómez,
  • Carmen Aspiroz,
  • Nazreen F. Hadjirin,
  • Daniel Benito,
  • Myriam Zarazaga,
  • Carmen Torres and
  • Mark A. Holmes

Methicillin-resistant Staphylococcus aureus (MRSA) sequence type (ST)398 is a livestock associated (LA) lineage with zoonotic potential, especially in humans with live pig contact. The objective of this study was to characterize two S. aureus strains...

  • Article
  • Open Access
6 Citations
4,760 Views
14 Pages

Hepatitis E Virus Seroprevalence and Associated Risk Factors in Apparently Healthy Individuals from Osun State, Nigeria

  • Folakemi Abiodun Osundare,
  • Patrycja Klink,
  • Catharina Majer,
  • Olusola Aanuoluwapo Akanbi,
  • Bo Wang,
  • Mirko Faber,
  • Dominik Harms,
  • C.-Thomas Bock and
  • Oladele Oluyinka Opaleye

Hepatitis E virus (HEV) infection is a major public health concern in low-income countries, yet incidence and prevalence estimates are often lacking. Serum (n = 653) and faecal (n = 150) samples were collected from apparently healthy individuals usin...

  • Article
  • Open Access
20 Citations
4,581 Views
17 Pages

Uncovering the First Atypical DS-1-like G1P[8] Rotavirus Strains That Circulated during Pre-Rotavirus Vaccine Introduction Era in South Africa

  • Peter N. Mwangi,
  • Milton T. Mogotsi,
  • Sebotsana P. Rasebotsa,
  • Mapaseka L. Seheri,
  • M. Jeffrey Mphahlele,
  • Valantine N. Ndze,
  • Francis E. Dennis,
  • Khuzwayo C. Jere and
  • Martin M. Nyaga

Emergence of DS-1-like G1P[8] group A rotavirus (RVA) strains during post-rotavirus vaccination period has recently been reported in several countries. This study demonstrates, for the first time, rare atypical DS-1-like G1P[8] RVA strains that circu...

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Pathogens - ISSN 2076-0817