Special Issue "Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (1 March 2020) | Viewed by 36748
A printed edition of this Special Issue is available here.
Interests: M. tuberculosis, enzymology, biochemistry, structural biology
Interests: biochemistry; structural biology; M. tuberculosis; DNA repair mechanisms
The global scale and the dramatic number of individuals that succumb to tuberculosis necessitates drastic measures to fight this widespread, debilitating disease. The last data provided by the World Health Organization (WHO) in their annual “Global Tuberculosis Report”  maintain tuberculosis as the ninth cause of death worldwide and the leading cause of mortality by a single infectious agent, with the highest rate of infections and death toll rate mostly concentrated in developing and low-income countries.
Tuberculosis is also considered an impairing factor for economic growth and for the improvement of the general public health in those countries, as it drains human and financial resources that would otherwise be invested in the economy . Hence, there is a pressing need to study and develop new prevention protocols and treatments for tuberculosis.
Public health policy makers, supranational organizations, and governing bodies are currently joining efforts in raising awareness in the general population regarding M. tuberculosis contagion and in establishing guidelines and protocols for fighting tuberculosis . At the same time, pharmaceutical companies research new therapies and approaches for finding new antitubercular diagnostics and treatments, the commercial sustainability of which should not be overlooked in order to make antitubercular treatments accessible and inclusive .
The aim of the current Special Issue is to collect, update, and harmonize the most recent literature on tuberculosis. We aim to touch herein the most relevant aspects of M. tuberculosis infection as well as its diagnosis and treatments, spanning from the understanding of the molecular mechanisms involved in pathogenesis, to the recapitulation of the host immune responses against tuberculosis, to the analysis of available tools for tuberculosis prevention, and to the latest advancements in antitubercular drug discovery.
Our intent is also to focus the attention not only on the aspects of tuberculosis research (although they are of fundamental importance for advancing antitubercular treatments), but also on the standpoints and the priorities of healthcare policy makers, who are those that contribute in dictating the guidelines to which governments and healthcare providers must adhere to fight tuberculosis.
While mainly dedicated to scientists and to experts in the field, this Special Issue reaches out to a broader audience with the aim of raising awareness not only on the scientific aspects of tuberculosis research, but also with the aim of encouraging the readers to gain a comprehensive vision of the multifaceted aspects of tuberculosis research, management, and treatment.
- World Health Organization Global tuberculosis Report WHO 2018; 2018; Vol. 69.
- Reid, M.J.A.; Arinaminpathy, N.; Bloom, A.; Bloom, B.R.; Boehme, C.; Chaisson, R.; Chin, D.P.; Churchyard, G.; Cox, H.; Ditiu, L.; et al. Building a tuberculosis-free world: The Lancet Commission on tuberculosis. Lancet 2019, 393, 1331–1384.
- Political declaration of the High-Level Meeting of the General Assembly on the Fight Against Tuberculosis : 2018.
- Treatment Action Group Tuberculosis Research Funding Trends 2005-2017; 2018;
Dr. Davide Maria Ferraris
Dr. Riccardo Miggiano
Prof. Dr. Menico Rizzi
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- M. tuberculosis
- host-pathogen interactions
- immune response
- antitubercular drug discovery
- antitubercular treatments