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A Review: Wolbachia-Based Population Replacement for Mosquito Control Shares Common Points with Genetically Modified Control Approaches

Unit Arboviruses and Insect Vectors, Department of Virology, Institut Pasteur, F-75724 Paris, France
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Pathogens 2020, 9(5), 404; https://doi.org/10.3390/pathogens9050404
Received: 15 April 2020 / Revised: 15 May 2020 / Accepted: 20 May 2020 / Published: 22 May 2020
(This article belongs to the Special Issue Untargeted Alternative Routes of Arbovirus Transmission)
The growing expansion of mosquito vectors has made mosquito-borne arboviral diseases a global threat to public health, and the lack of licensed vaccines and treatments highlight the urgent need for efficient mosquito vector control. Compared to genetically modified control strategies, the intracellular bacterium Wolbachia, endowing a pathogen-blocking phenotype, is considered an environmentally friendly strategy to replace the target population for controlling arboviral diseases. However, the incomplete knowledge regarding the pathogen-blocking mechanism weakens the reliability of a Wolbachia-based population replacement strategy. Wolbachia infections are also vulnerable to environmental factors, temperature, and host diet, affecting their densities in mosquitoes and thus the virus-blocking phenotype. Here, we review the properties of the Wolbachia strategy as an approach to control mosquito populations in comparison with genetically modified control methods. Both strategies tend to limit arbovirus infections but increase the risk of selecting arbovirus escape mutants, rendering these strategies less reliable. View Full-Text
Keywords: mosquito control; replacement strategy; Wolbachia; environmental factors; arbovirus; viral adaptation mosquito control; replacement strategy; Wolbachia; environmental factors; arbovirus; viral adaptation
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Yen, P.-S.; Failloux, A.-B. A Review: Wolbachia-Based Population Replacement for Mosquito Control Shares Common Points with Genetically Modified Control Approaches. Pathogens 2020, 9, 404.

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