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Diagnostics, Volume 15, Issue 13

2025 July-1 - 159 articles

Cover Story: Peripheral nerve injuries represent a significant challenge in legal medicine, and their proper management and evaluation are at the intersection of clinical medicine, anatomical science, and legal medicine. In this review, we aimed to integrate current knowledge about the anatomy, physiology, clinical management, and paraclinical assessment of peripheral nerve injuries, targeted explicitly for medical–legal practice. We conducted a comprehensive review of the medical–legal evaluation framework needed to evaluate peripheral nerve injuries, with particular emphasis on anatomical variations, imaging techniques, and methods to assess the timing of injury. View this paper
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Articles (159)

  • Article
  • Open Access
6 Citations
3,258 Views
17 Pages

RADAI: A Deep Learning-Based Classification of Lung Abnormalities in Chest X-Rays

  • Hanan Aljuaid,
  • Hessa Albalahad,
  • Walaa Alshuaibi,
  • Shahad Almutairi and ,
  • Tahani Hamad Aljohani,
  • Nazar Hussain and
  • Farah Mohammad
  • + 2 authors+ 0 author

Background: Chest X-rays are rapidly gaining prominence as a prevalent diagnostic tool, as recognized by the World Health Organization (WHO). However, interpreting chest X-rays can be demanding and time-consuming, even for experienced radiologists, l...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
1,906 Views
13 Pages

Bisphosphonate Use and Cardiovascular Outcomes According to Kidney Function Status in Post-Menopausal Women: An Emulated Target Trial from the Multi-Ethnic Study of Atherosclerosis

  • Elena Ghotbi,
  • Nikhil Subhas,
  • Michael P. Bancks,
  • Sammy Elmariah and ,
  • Jonathan L. Halperin,
  • David A. Bluemke,
  • Bryan R Kestenbaum,
  • R. Graham Barr,
  • Wendy S. Post and
  • Shadpour Demehri
  • + 7 authors+ 2 authors

Background/Objectives: Bisphosphonates may influence vascular calcification and atheroma formation via farnesyl pyrophosphate synthase inhibition in the mevalonate pathway regulating bone and lipid metabolism. However, the clinical impact of NCB use...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Review
  • Open Access
3 Citations
2,229 Views
9 Pages

Pressure Gradient-Driven Embolization b-TACE for HCC: Technical and Diagnostic Step-by-Step Procedural Guide and Literature Review

  • Bianca Rocco,
  • David C. Madoff,
  • Fabrizio Basilico,
  • Elio Damato and ,
  • Paolo Vetri,
  • Valeria Panebianco,
  • Carlo Catalano and
  • Pierleone Lucatelli
  • + 3 authors+ 0 author

Background: Hepatocellular carcinoma (HCC) is one of the leading cause of cancer death worldwide. Transarterial therapies represent an important tool in the management of different clinical scenarios, from a patient with a single nodule to a patient...

(This article belongs to the Special Issue Advancements in Interventional Radiology Techniques in Vascular and Extravascular Diseases)
  • Article
  • Open Access
1 Citations
2,241 Views
10 Pages

The Effect of Intrauterine Device Use on the Quality of Sampling Material in Patients Undergoing Endometrial Biopsy

  • Hüseyin Aksoy,
  • Mehmet Çopuroğlu,
  • Mehmet Genco,
  • Merve Genco and
  • Mürüvet Korkmaz Baştürk

Objective: This retrospective study aims to evaluate the effect of copper intrauterine device (Cu-IUD) use on the adequacy and diagnostic quality of endometrial biopsy specimens in women with abnormal uterine bleeding (AUB). Patients with levonorgest...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
11 Citations
4,900 Views
18 Pages

Changing Etiological Spectrum of Premature Ovarian Insufficiency over the Past Decades: A Comparative Analysis of Two Cohorts from a Single Center

  • Szilvia Csehely,
  • Adrienn Kun,
  • Edina Orbán,
  • Tamás Katona and ,
  • Mónika Orosz,
  • Zoárd Tibor Krasznai,
  • Tamás Deli and
  • Attila Jakab
  • + 3 authors+ 0 author

Background: Premature ovarian insufficiency (POI) is a complex and heterogeneous condition affecting women of reproductive age. Historically, most POI cases have been classified as idiopathic due to limited diagnostic capabilities. However, due to th...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
3 Citations
1,435 Views
16 Pages

Perioperative Risk Prediction in Major Gynaecological Oncology Surgery: A National Diagnostic Survey of UK Clinical Practice

  • Lusine Sevinyan,
  • Anil Tailor,
  • Pradeep Prabhu,
  • Peter Williams and ,
  • Melanie Flint and
  • Thumuluru Kavitha Madhuri
  • + 1 author+ 0 author

Background: Gynaecological oncology (GO) surgery involves a wide range of procedures, from minor diagnostic interventions to highly complex cytoreductive operations. Accurate perioperative diagnostics—particularly in major surgery—are cri...

(This article belongs to the Special Issue New Insights into the Diagnosis of Gynecological Diseases)
  • Case Report
  • Open Access
1 Citations
1,728 Views
15 Pages

Two Cases of Chronic Tubular Necrosis Presenting as Fanconi Syndrome Induced by Red Yeast Rice Choleste-Help

  • Kanako Mita,
  • Shunsuke Takahashi,
  • Satoshi Yanagida,
  • Akihiro Aoyama and ,
  • Takayuki Shiraishi,
  • Takayuki Hamada,
  • Yumiko Nakamura,
  • Mariko Sato,
  • Kento Hirose and
  • Akito Maeshima
  • + 11 authors+ 6 authors

Background and Clinical Significance: Although dietary supplements have often been deemed safe, some have been linked to drug-induced nephropathy due to their diverse ingredients. The aim of this report is to enhance clinical awareness of a novel and...

(This article belongs to the Special Issue Kidney Disease: Biomarkers, Diagnosis, and Prognosis: 3rd Edition)
  • Article
  • Open Access
1 Citations
1,446 Views
12 Pages

Background/Objectives: A thorough understanding of tooth anatomy is essential for effective root canal treatment. This study aims to investigate the root canal morphology of mandibular incisors (MIs) and the presence of distolingual roots in mandibul...

(This article belongs to the Special Issue Advances in Dental Imaging)
  • Article
  • Open Access
2,266 Views
10 Pages

Assessing the Reliability of D-Dimer Measurement in EDTA Plasma: A Comparison to the Established Citrate Method

  • Daniel Pfingst,
  • Adriana Méndez,
  • Peter Neyer,
  • Henning Nilius and ,
  • Nicole Schaub,
  • Patricia Keusch,
  • Michael Nagler and
  • Angelika Hammerer-Lercher
  • + 3 authors+ 0 author

Background: D-dimer determined in citrated plasma is a well-established and efficient biomarker, particularly for ruling out venous thromboembolism. In certain clinical settings, the availability of citrated plasma may pose challenges when not readil...

(This article belongs to the Section Clinical Laboratory Medicine)
  • Article
  • Open Access
1,630 Views
16 Pages

Variability of Metabolic Rate and Distribution Volume Quantification in Whole-Body Parametric PATLAK [18F]-FDG PET/CT—A Prospective Trial in Patients with Lung Cancer

  • Stephan Ursprung,
  • Lars Zender,
  • Patrick Ghibes,
  • Florian Hagen and ,
  • Konstantin Nikolaou,
  • Christian la Fougère and
  • Matthias Weissinger
  • + 2 authors+ 0 author

Background: The recent introduction of whole-body positron emission tomography/ computed tomography (PET/CT) scanners and multi-bed, multi-time point acquisition technique enable calculating fluorodeoxyglucose (FDG) kinetics in the whole body. Howeve...

(This article belongs to the Special Issue PET/CT Imaging in Oncology: Clinical Advances and Perspectives)
  • Interesting Images
  • Open Access
1,041 Views
5 Pages

Durable Disease Control in Primary Pulmonary Sarcomatoid Carcinoma Following Pneumonectomy

  • Cheng-Shiun Shiue,
  • Chao-Chun Chang,
  • Meng-Ta Tsai and
  • Yu-Ning Hu

We report a 26-year-old male presenting with a chronic cough and hemoptysis. Imaging revealed a large hypermetabolic mass in the left lower lung with the invasion of adjacent great vessels. A biopsy confirmed sarcomatoid carcinoma, a rare and aggress...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
2,804 Views
15 Pages

Background/Objectives: Adequate bowel preparation is essential for high-quality colonoscopy. The clarity of the final rectal effluent can predict its sufficiency and guide additional preparation if necessary. For an objective and reliable clarity ass...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
1 Citations
1,609 Views
11 Pages

Adrenal Vein Sampling: The Role of a Diagnostic Inspiratory Contrast-Enhanced CT Scan in Interventional Planning

  • Filip Njavro,
  • Erin Kos,
  • Karin Zibar Tomšić,
  • Maja Prutki and
  • Ana Marija Alduk

Background/Objectives: Adrenal vein sampling is the gold standard for differentiating between unilateral and bilateral primary aldosteronism and guiding treatment. This study evaluates the utility of inspiratory CT scans in interventional planning, s...

(This article belongs to the Special Issue Abdominal Diseases: Diagnosis, Treatment and Management)
  • Article
  • Open Access
2 Citations
2,195 Views
12 Pages

Clinical Utility of Plasma Microbial Cell-Free DNA Surveillance in Neutropenic Patients with Acute Myeloid Leukemia Undergoing Outpatient Chemotherapy: A Case Series

  • Maria Lampou,
  • Elizabeth C. Trull,
  • Hailey M. Warren,
  • Musie S. Ghebremichael and ,
  • Raja Nakka,
  • Daniel J. Floyd,
  • Amir T. Fathi,
  • Andrew M. Brunner and
  • Michael K. Mansour
  • + 4 authors+ 0 author

Background/Objectives: The main objective of the study is to assess the clinical utility of microbial cell-free DNA (mcfDNA) in neutropenic patients diagnosed with acute myeloid leukemia (AML) undergoing chemotherapy in the outpatient setting. Neutro...

(This article belongs to the Special Issue Recent Advances in Hematology and Oncology, 2nd Edition)
  • Article
  • Open Access
6 Citations
1,958 Views
12 Pages

Automatic Segmentation of the Infraorbital Canal in CBCT Images: Anatomical Structure Recognition Using Artificial Intelligence

  • Ismail Gumussoy,
  • Emre Haylaz,
  • Suayip Burak Duman,
  • Fahrettin Kalabalık and ,
  • Muhammet Can Eren,
  • Seyda Say,
  • Ozer Celik and
  • Ibrahim Sevki Bayrakdar
  • + 3 authors+ 0 author

Background/Objectives: The infraorbital canal (IOC) is a critical anatomical structure that passes through the anterior surface of the maxilla and opens at the infraorbital foramen, containing the infraorbital nerve, artery, and vein. Accurate locali...

(This article belongs to the Special Issue Advancements in Artificial Intelligence for Dentomaxillofacial Radiology—2nd Edition)
  • Review
  • Open Access
16 Citations
7,936 Views
24 Pages

Artificial Intelligence in Primary Malignant Bone Tumor Imaging: A Narrative Review

  • Platon S. Papageorgiou,
  • Rafail Christodoulou,
  • Panagiotis Korfiatis,
  • Dimitra P. Papagelopoulos and ,
  • Olympia Papakonstantinou,
  • Nancy Pham,
  • Amanda Woodward and
  • Panayiotis J. Papagelopoulos
  • + 3 authors+ 0 author

Artificial Intelligence (AI) has emerged as a transformative force in orthopedic oncology, offering significant advances in the diagnosis, classification, and prediction of treatment response for primary malignant bone tumors (PBT). Through machine l...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Review
  • Open Access
1,801 Views
16 Pages

Magnetic Resonance Imaging in the Evaluation of the Stress System in Acute and Chronic Cardiac Disease

  • George Markousis-Mavrogenis,
  • Flora Bacopoulou,
  • George Chrousos and
  • Sophie I. Mavrogeni

Various cardiac pathologies such as ischemic/non-ischemic heart disease, valvular heart disease and genetic heart disease may impair cardiac function and lead to heart failure (HF). Each individual condition but also the common endpoint of HF may inv...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
2,013 Views
13 Pages

Background: Although autoimmune diseases differ in their pathogenesis, B cells play a central role in many of them, and alterations in peripheral B cell subpopulations have been observed. Therefore, we aimed to explore the possibility of peripheral B...

(This article belongs to the Section Clinical Laboratory Medicine)
  • Article
  • Open Access
2 Citations
1,845 Views
13 Pages

Stent Failure Management in Contemporary Clinical Practice

  • Iosif Xenogiannis,
  • Charalampos Varlamos,
  • Despoina-Rafailia Benetou,
  • Vassiliki-Maria Dragona and ,
  • Stefanos Vlachos,
  • Christos Pappas,
  • Fotios Kolokathis and
  • Grigoris V. Karamasis
  • + 3 authors+ 0 author

Background: Although contemporary stent technology has significantly evolved, a substantial number of patients present with stent failure (SF), the clinical expression of which is either in-stent restenosis (ISR) or stent thrombosis (ST). Methods: In...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Review
  • Open Access
3 Citations
5,376 Views
16 Pages

The Sensory Gatekeeper of the Larynx: Anatomy and Clinical Importance of the Internal Branch of the Superior Laryngeal Nerve

  • Alexandra Diana Vrapciu,
  • Iulian Brezean,
  • Răzvan Costin Tudose,
  • Mugurel Constantin Rusu and ,
  • George Triantafyllou and
  • Maria Piagkou
  • + 1 author+ 0 author

The internal branch of the superior laryngeal nerve (IbSLN) plays a critical role in the sensory innervation of the supraglottic larynx. It is essential for protective reflexes such as coughing and swallowing. This nerve is frequently at risk during...

(This article belongs to the Special Issue Clinical Anatomy and Diagnosis of Peripheral Nervous System)
  • Review
  • Open Access
15 Citations
5,975 Views
18 Pages

Challenges, Difficulties, and Delayed Diagnosis of Multiple Myeloma

  • Tugba Zorlu,
  • Merve Apaydin Kayer,
  • Nazik Okumus,
  • Turgay Ulaş and ,
  • Mehmet Sinan Dal and
  • Fevzi Altuntas
  • + 1 author+ 0 author

Background: Multiple myeloma (MM) is a heterogeneous plasma cell malignancy with non-specific symptoms and disease heterogeneity at clinical and biological levels. This non-specific set of symptoms, including bone pain, anemia, renal failure, hyperca...

(This article belongs to the Special Issue Recent Advances in Hematology and Oncology)
  • Article
  • Open Access
2,102 Views
13 Pages

Correlation Between MRI Characteristic of Osteosarcoma with 2-Year Survival Outcomes

  • Mohd Noor Akmal Adam,
  • Emilia Rosniza Mohammed Rusli,
  • Erica Yee Hing,
  • Juliana Fairuz Maktar and ,
  • Ckhai Loh,
  • Nor Hazla Mohamed Haflah and
  • Faizah Mohd Zaki
  • + 2 authors+ 0 author

Background: Magnetic resonance imaging (MRI) plays a crucial role in staging and preoperative evaluation in osteosarcoma patient. Fewer studies have focused on 2-year survival, which reflects tumour aggressiveness and early disease progression. This...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Interesting Images
  • Open Access
1 Citations
1,314 Views
5 Pages

Early-Onset Retinal Dysfunction Associated with Novel WDR19 Variants in Sensenbrenner Syndrome

  • Bogumiła Wójcik-Niklewska,
  • Zofia Oliwa,
  • Zofia Zdort and
  • Adrian Smędowski

Sensenbrenner syndrome, or cranioectodermal dysplasia (CED), is a rare autosomal recessive ciliopathy characterized by craniofacial, skeletal, ectodermal, and renal abnormalities. Ocular involvement, though infrequent, can include retinal dystrophy w...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Editorial
  • Open Access
1 Citations
1,742 Views
6 Pages

The Big Data Era in Cardiology and Cardiovascular Medicine: Advanced Analytics for Truly Personalized Care

  • Pasquale Ambrosino,
  • Fabio Manzo,
  • Claudio Candia,
  • Giorgio Alfredo Spedicato and ,
  • Guido Grassi and
  • Mauro Maniscalco
  • + 1 author+ 0 author

In recent years, a growing body of alarming epidemiological evidence has suggested that cardiovascular diseases (CVDs) are the leading cause of disability and premature mortality worldwide [...]

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
5 Citations
4,112 Views
10 Pages

Evaluating the Predictive Value of HOMA-IR in Gestational Diabetes: A Case–Control Study from Romania

  • Ait el Haj Iman,
  • Cristina Onel,
  • Gheorghe Furau,
  • Cristian Furau and ,
  • Roxana Furau,
  • Mihai Lucan,
  • Mircea Sandor,
  • Liliana Sachelarie and
  • Anca Huniadi
  • + 4 authors+ 0 author

Background/Objectives: Gestational diabetes mellitus (GDM) is a common metabolic disorder during pregnancy, associated with increased risks for both maternal and fetal complications. Insulin resistance plays a central role in its pathophysiology. Thi...

(This article belongs to the Special Issue Insights into Perinatal Medicine and Fetal Medicine—2nd Edition)
  • Article
  • Open Access
1,460 Views
11 Pages

OCT Angiography Assessment of Type 1 Diabetes Mellitus Patients Without Diabetic Retinopathy: A 3-Year Follow-Up Study

  • Alexandra Oltea Dan,
  • Carmen Luminița Mocanu,
  • Alin Ștefan Ștefănescu-Dima,
  • Andreea Cornelia Tănasie and ,
  • Veronica Elena Maria,
  • Anca Elena Târtea and
  • Andrei Theodor Bălășoiu
  • + 2 authors+ 0 author

Background/Objectives: This study aims to investigate the progression of retinal microvascular changes using OCTA in young T1DM patients without clinical signs of DR over a period of 3 years. Methods: This prospective, longitudinal study analyzed OCT...

(This article belongs to the Section Biomedical Optics)
  • Article
  • Open Access
3 Citations
1,969 Views
13 Pages

Cranial Vault Deformation and Its Association with Mandibular Deviation in Patients with Facial Asymmetry: A CT-Based Study

  • Mayuko Nishimura,
  • Chie Tachiki,
  • Taiki Morikawa,
  • Dai Ariizumi and ,
  • Satoru Matsunaga,
  • Keisuke Sugahara,
  • Yasuo Aihara,
  • Akira Watanabe,
  • Akira Katakura and
  • Yasushi Nishii
  • + 6 authors+ 1 author

Background/Objectives: Facial asymmetry is known to cause not only deformities in the facial skeleton but also alterations in the cranial vault. However, limited research has explored the association between mandibular asymmetry and cranial vault def...

(This article belongs to the Topic Assessment of Craniofacial Morphology: Traditional Methods and Innovative Approaches)
  • Article
  • Open Access
2 Citations
1,389 Views
20 Pages

Retinal Vessel Diameter Reductions Are Associated with Retinal Ganglion Cell Dysfunction, Thinning of the Ganglion Cell and Inner Plexiform Layers, and Decreased Visual Field Global Indices in Glaucoma Suspects

  • Andrew Tirsi,
  • Nicholas Leung,
  • Rohun Gupta,
  • Sungmin Hong and ,
  • Derek Orshan,
  • Joby Tsai,
  • Corey Ross Lacher,
  • Isabella Tello,
  • Samuel Potash and
  • Celso Tello
  • + 7 authors+ 2 authors

Background/Objectives: The aim of this study was to evaluate the associations between optical coherence tomography angiography (OCTA)-based retinal vessel diameter (RVD) measurements, with retinal ganglion cell (RGC) function assessed by means of ste...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
1,081 Views
16 Pages

Macular Microvasculature Is Different in Patients with Primary Sjögren’s Disease Compared to Healthy Controls

  • Gyde Tadsen,
  • Nadine Zehrfeld,
  • Laura Hoffmann,
  • Marten Gehlhaar and ,
  • Bettina Hohberger,
  • Christian Mardin,
  • Torsten Witte,
  • Carsten Framme,
  • Diana Ernst and
  • Katerina Hufendiek
  • + 5 authors+ 0 author

Background/Objectives: This study investigates the macular microvasculature in a large cohort of primary Sjögren’s disease (SjD) patients using optical coherence tomography angiography (OCTA), focusing on how disease duration, activity, an...

(This article belongs to the Special Issue Applications of Optical Coherence Tomography and Optical Coherence Tomography Angiography in Ophthalmology)
  • Review
  • Open Access
3 Citations
1,944 Views
14 Pages

Simplified Artificial Intelligence Terminology for Pathologists

  • Fatemeh Zabihollahy,
  • Michael Mankaruos,
  • Maxim Mohareb,
  • Timothy Youssef and ,
  • Yasaman Soleymani and
  • George M. Yousef
  • + 1 author+ 0 author

The expanding shift towards digital pathology in clinical practice globally highlights its potential to enhance patient care through artificial intelligence (AI)-powered, computer-assisted diagnostics. Effective communication between AI scientists an...

(This article belongs to the Special Issue Latest News in Digital Pathology)
  • Article
  • Open Access
4 Citations
1,444 Views
17 Pages

Breaking Diagnostic Barriers: Vision Transformers Redefine Monkeypox Detection

  • Gelan Ayana,
  • Beshatu Debela Wako,
  • So-yun Park,
  • Jude Kong and ,
  • Sahng Min Han,
  • Soon-Do Yoon and
  • Se-woon Choe
  • + 2 authors+ 0 author

Background/Objective: The global spread of Monkeypox (Mpox) has highlighted the urgent need for rapid, accurate diagnostic tools. Traditional methods like polymerase chain reaction (PCR) are resource-intensive, while skin image-based detection offers...

(This article belongs to the Special Issue Recent Advances in Epidemiological Diagnostics: Detecting and Controlling Infectious Diseases)
  • Article
  • Open Access
2 Citations
3,381 Views
18 Pages

Purpose: This study aims to evaluate the clinical utility of a prototype ultra-widefield (UWF) single-capture optical coherence tomography (OCT) lens developed to image large areas of the retina. Material and Methods: This study included OCT and angi...

(This article belongs to the Special Issue State of the Art in Retinal Optical Coherence Tomography Images)
  • Article
  • Open Access
1 Citations
1,764 Views
16 Pages

Uterine Artery Doppler in Complicated Twin Pregnancies

  • Dagmara Filipecka-Tyczka,
  • Anna Scholz,
  • Monika Szpotańska-Sikorska,
  • Katarzyna Muzyka-Placzyńska and ,
  • Artur Pokropek,
  • Michał Rabijewski,
  • Bożena Wroczyńska,
  • Marcin Wieczorek,
  • Małgorzata Zielińska and
  • Grzegorz Szewczyk
  • + 9 authors+ 4 authors

Background: We assessed the relationship between uterine artery (UtA) indices and the occurrence of obstetrical complications in twin pregnancies. Methods: It was a longitudinal, prospective observation of the UtA indices and obstetric outcomes in tw...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
9 Citations
5,000 Views
9 Pages

A Comparative Evaluation of the Chemiluminescence Immunoassay and ELISA for the Detection of Islet Autoantibodies in Type 1 Diabetes

  • Elisa Danese,
  • Claudia Piona,
  • Mariateresa Rizza,
  • Elena Tiziani and ,
  • Laura Pighi,
  • Elisa Morotti,
  • Gian Luca Salvagno,
  • Camilla Mattiuzzi,
  • Claudio Maffeis and
  • Giuseppe Lippi
  • + 5 authors+ 0 author

Background: The early detection of type 1 diabetes (T1D) through screening for major islet autoantibodies is receiving increasing attention as a public health strategy, exemplified by the recent implementation of a pilot pediatric screening program i...

(This article belongs to the Section Clinical Laboratory Medicine)
  • Article
  • Open Access
2 Citations
1,384 Views
18 Pages

Toward New Assessment in Sarcoma Identification and Grading Using Artificial Intelligence Techniques

  • Arnar Evgení Gunnarsson,
  • Simona Correra,
  • Carol Teixidó Sánchez,
  • Marco Recenti and ,
  • Halldór Jónsson and
  • Paolo Gargiulo
  • + 1 author+ 0 author

Background/Objectives: Sarcomas are a rare and heterogeneous group of malignant tumors, which makes early detection and grading particularly challenging. Diagnosis traditionally relies on expert visual interpretation of histopathological biopsies and...

(This article belongs to the Special Issue Artificial Intelligence in Clinical Decision Support—2nd Edition)
  • Article
  • Open Access
2 Citations
2,614 Views
15 Pages

An Integrated System for Detecting and Numbering Permanent and Deciduous Teeth Across Multiple Types of Dental X-Ray Images Based on YOLOv8

  • Ya-Yun Huang,
  • Chiung-An Chen,
  • Yi-Cheng Mao,
  • Chih-Han Li and ,
  • Bo-Wei Li,
  • Tsung-Yi Chen,
  • Wei-Chen Tu and
  • Patricia Angela R. Abu
  • + 3 authors+ 0 author

Background/Objectives: In dental medicine, the integration of various types of X-ray images, such as periapical (PA), bitewing (BW), and panoramic (PANO) radiographs, is crucial for comprehensive oral health assessment. These complementary imaging mo...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
2 Citations
2,082 Views
12 Pages

Optimal Number of Needle Punctures in EUS-FNA/B with ROSE for Solid Pancreatic Lesions

  • Naomi Uchiyama,
  • Hiroshi Kawakami,
  • Yoshinori Ozono,
  • Hiroshi Hatada and ,
  • Soichiro Ogawa,
  • Satoshi Sekiguchi,
  • Hiroshi Noguchi and
  • Yuichiro Sato
  • + 3 authors+ 0 author

Background and Objectives: Endoscopic ultrasonography (EUS)-guided fine-needle aspiration/biopsy (FNA/B) is widely used for solid pancreatic lesions; however, the optimal number of needle punctures required to achieve high diagnostic accuracy remains...

(This article belongs to the Special Issue Diagnosis of Pancreatic Diseases)
  • Article
  • Open Access
3 Citations
1,396 Views
12 Pages

Power Indices Through Rotational Inertial Devices for Lower Extremity Profiling and Injury Risk Stratification in Professional Soccer Players: A Cross-Sectional Study

  • Álvaro Murillo-Ortiz,
  • Javier Raya-González,
  • Moisés Falces-Prieto,
  • Samuel López-Mariscal and ,
  • Francisco Javier Iglesias-García and
  • Luis Manuel Martínez-Aranda
  • + 1 author+ 0 author

Background/Objectives: Power indices may provide valuable information for performance and injury prevention in soccer players, so increasing the knowledge about them seems essential. Therefore, this study aimed to establish limb-specific normative va...

(This article belongs to the Special Issue Orthopedics and the Musculoskeletal System: Diagnosis, Prognosis, and Mechanisms)
  • Article
  • Open Access
2 Citations
2,718 Views
14 Pages

Is Altered Surfactant Protein Gene Expression in Peripheral Blood Associated with COVID-19 Disease Severity?

  • Suna Koc,
  • Kamil Cankut Senturk,
  • Sefa Cetinkaya,
  • Guven Yenmis and ,
  • Hulya Arkan,
  • Mahmut Demirbilek,
  • Pinar Acar,
  • Erhan Arikan and
  • Mehmet Dokur
  • + 4 authors+ 0 author

Background/Objectives: Severe COVID-19 pneumonia damages alveolar type II cells and disrupts surfactant homeostasis, contributing to acute respiratory distress syndrome (ARDS). Surfactant proteins (SP-A, SP-B, SP-C, SP-D) are critical for reducing al...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Interesting Images
  • Open Access
966 Views
3 Pages

Quadricuspid Aortic Valve: Out of the Shadows, into the Light

  • Dmitri Panfilov,
  • Elizaveta Petrakova and
  • Boris Kozlov

We present the case of a 63-year-old man with severe aortic valve regurgitation and left-ventricular dysfunction. The patient was scheduled for elective surgery. A quadricuspid aortic valve with fibrous thickening and calcification of the cusps was v...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
3 Citations
5,342 Views
32 Pages

Blue Light and Green Light Fundus Autofluorescence, Complementary to Optical Coherence Tomography, in Age-Related Macular Degeneration Evaluation

  • Antonia-Elena Ranetti,
  • Horia Tudor Stanca,
  • Mihnea Munteanu,
  • Raluca Bievel Radulescu and
  • Simona Stanca

Background: Age-related macular degeneration (AMD) is one of the leading causes of permanent vision loss in the elderly, particularly in higher-income countries. Fundus autofluorescence (FAF) imaging is a widely used, non-invasive technique that comp...

(This article belongs to the Section Biomedical Optics)
  • Article
  • Open Access
5 Citations
4,886 Views
15 Pages

Background/Objectives: Accurately correlating mammographic findings with corresponding histopathologic features is considered one of the essential aspects of mammographic evaluation, guiding the next steps in cancer management and preventing overdiag...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
22 Citations
2,625 Views
20 Pages

Optimizing Esophageal Cancer Diagnosis with Computer-Aided Detection by YOLO Models Combined with Hyperspectral Imaging

  • Wei-Chun Weng,
  • Chien-Wei Huang,
  • Chang-Chao Su,
  • Arvind Mukundan and ,
  • Riya Karmakar,
  • Tsung-Hsien Chen,
  • Amey Rajesh Avhad,
  • Chu-Kuang Chou and
  • Hsiang-Chen Wang
  • + 4 authors+ 0 author

Objective: Esophageal cancer (EC) is difficult to visually identify, rendering early detection crucial to avert the advancement and decline of the patient’s health. Methodology: This work aimed to acquire spectral information from EC images via...

(This article belongs to the Section Biomedical Optics)
  • Article
  • Open Access
984 Views
9 Pages

Predictors of Impaired Treatment Outcomes in COVID-19: A Single-Center Observational Study from Serbia

  • Tatjana Adzic-Vukicevic,
  • Milan Racic,
  • Nikolina Tovarisic-Racic,
  • Marija Laban-Lazovic and ,
  • Sead Dalifi and
  • Jovana Radmilovic
  • + 1 author+ 0 author

Background: COVID-19 disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2); it is characterized by a hypercoagulable state that results in an increased risk for embolic and thrombotic vascular complications. The incidence of...

(This article belongs to the Special Issue Advances in the Diagnosis and Management of Respiratory Illnesses)
  • Article
  • Open Access
9 Citations
1,623 Views
19 Pages

Predicting the Recurrence of Differentiated Thyroid Cancer Using Whale Optimization-Based XGBoost Algorithm

  • Keshika Shrestha,
  • H. M. Jabed Omur Rifat,
  • Uzzal Biswas,
  • Jun-Jiat Tiang and
  • Abdullah-Al Nahid

Background/Objectives: Differentiated Thyroid Cancer (DTC), comprising papillary and follicular carcinomas, is the most common type of thyroid cancer. This is highly infectious and increasing at a higher rate. Some patients experience recurrence even...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Systematic Review
  • Open Access
20 Citations
7,075 Views
27 Pages

Leaky Gut Biomarkers as Predictors of Depression and Suicidal Risk: A Systematic Review and Meta-Analysis

  • Donato Morena,
  • Matteo Lippi,
  • Matteo Scopetti,
  • Emanuela Turillazzi and
  • Vittorio Fineschi

Background: The gut–brain axis (GBA) has been demonstrated to be involved in normal neurodevelopment, with its dysfunction potentially contributing to the onset of mental disorders. In this systematic review and meta-analysis, we aimed to exami...

(This article belongs to the Special Issue Advances in the Diagnosis and Management of Neuropsychiatric Disorders—2nd Edition)
  • Article
  • Open Access
1 Citations
1,441 Views
12 Pages

Structural Retinal and Optic Nerve Changes in Prostate Cancer Patients Receiving Androgen Receptor Pathway Inhibitors: An OCT-Based In Vivo Analysis

  • Yasemin Bakkal Temi,
  • Büşra Yılmaz Tuğan,
  • İlkay Çıtakkul,
  • Ece Baydar and ,
  • Gözde Karaca,
  • Sibel Balcı,
  • Devrim Çabuk,
  • Umut Kefeli,
  • Nurşen Yüksel and
  • Kazım Uygun
  • + 5 authors+ 0 author

Objective: To conduct a comparative analysis of layer-by-layer macular thickness, peripapillary retinal nerve fiber layer (pRNFL), and minimum rim width (MRW) between the eyes of patients with prostate cancer undergoing treatment with androgen recept...

(This article belongs to the Special Issue Advances in Eye Imaging)
  • Article
  • Open Access
2 Citations
1,844 Views
13 Pages

Deep Learning-Enhanced T1-Weighted Imaging for Breast MRI at 1.5T

  • Susann-Cathrin Olthof,
  • Marcel Dominik Nickel,
  • Elisabeth Weiland,
  • Daniel Leyhr and ,
  • Saif Afat,
  • Konstantin Nikolaou and
  • Heike Preibsch
  • + 2 authors+ 0 author

Background/Objectives: Assessment of a novel deep-learning (DL)-based T1w volumetric interpolated breath-hold (VIBEDL) sequence in breast MRI in comparison with standard VIBE (VIBEStd) for image quality evaluation. Methods: Prospective study of 52 br...

(This article belongs to the Special Issue Advances in Diagnosis and Prognosis of Breast Cancer)
  • Review
  • Open Access
2 Citations
3,690 Views
24 Pages

Expanding Role of Contrast-Enhanced Ultrasound and Elastography in the Evaluation of Abdominal Pathologies in Children

  • Natae Fekadu Lemessa,
  • Laith R. Sultan,
  • Santiago Martinez-Correa,
  • Laura May Davis and
  • Misun Hwang

Contrast-enhanced ultrasound and elastography are two ultrasound technologies that are becoming increasingly popular in the evaluation of different abdominal pathologies in children. The use of these technologies has expanded the diagnostic scope of...

(This article belongs to the Special Issue Abdominal Ultrasound: A Left Behind Area)
  • Review
  • Open Access
6 Citations
9,064 Views
18 Pages

Management and Treatment of Carotid Stenosis: Overview of Therapeutic Possibilities and Comparison Between Interventional Radiology, Surgery and Hybrid Procedure

  • Lorenzo Aliotta,
  • Livio Maria Gavazzi,
  • Pierantonio Malfa,
  • Pietro Valerio Foti and ,
  • Stefano Palmucci,
  • Maria Chiara Lo Greco,
  • Corrado Spatola,
  • Corrado Inì,
  • Francesco Tiralongo and
  • Emanuele David
  • + 12 authors+ 7 authors

Carotid stenosis is a common pathology in clinical practice and unfortunately carries a high risk of serious cerebrovascular events. The early recognition of carotid plaque and, consequently, a careful analysis by means of multimodal imaging are the...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

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Diagnostics - ISSN 2075-4418