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Diagnostics, Volume 15, Issue 15

August-1 2025 - 147 articles

Cover Story: Cardiac troponins are essential for the diagnosis of acute coronary syndromes, and the 99th percentile upper reference limit of troponin in the general population can be used to diagnose patients with myocardial injury. The Roche high-sensitivity troponin T assay is the only troponin T assay that has been recommended by the European Society of Cardiology for use in its rapid rule-out algorithms. In this paper, we report the performance of the new Sysmex high-sensitivity troponin T assay compared to the Roche troponin T assay and establish the high-sensitivity status of the Sysmex assay. In addition, we derived the 99th percentile upper reference limit for the Sysmex assay in both males and females in a healthy multi-ethnic population, and report the trends observed with increasing age and renal dysfunction. View this paper
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Articles (147)

  • Article
  • Open Access
1 Citations
829 Views
27 Pages

Multidisciplinary, Clinical Assessment of Accelerated Deep-Learning MRI Protocols at 1.5 T and 3 T After Intracranial Tumor Surgery and Their Influence on Residual Tumor Perception

  • Christer Ruff,
  • Till-Karsten Hauser,
  • Constantin Roder,
  • Daniel Feucht,
  • Paula Bombach,
  • Leonie Zerweck,
  • Deborah Staber,
  • Frank Paulsen,
  • Ulrike Ernemann and
  • Georg Gohla

Background/Objectives: Postoperative MRI is crucial for detecting residual tumor, identifying complications, and planning subsequent therapy. This study evaluates accelerated deep learning reconstruction (DLR) versus standard clinical protocols for e...

  • Article
  • Open Access
683 Views
20 Pages

Data Analytics and Machine Learning Models on COVID-19 Medical Reports Enhanced with XAI for Usability

  • Oliver Lohaj,
  • Ján Paralič,
  • Zuzana Paraličová,
  • Daniela Javorská and
  • Elena Zagorová

Objective—To identify effective data analytics and machine learning solutions that can help in the decision-making process in the medical domain and contribute to the understanding of COVID-19 disease. In this study, we analyze data from anonym...

  • Article
  • Open Access
1,163 Views
12 Pages

Factors Affecting Thyroid Volume in Children Aged 4 to 18 Years

  • Nevena Folić,
  • Marko Folić,
  • Miloš N. Milosavljević,
  • Ana V. Pejčić,
  • Slobodan Janković,
  • Maja Vulović,
  • Milos Stepovic,
  • Isidora Mihajlović and
  • Jovana Milosavljević

Background and Objectives: Ultrasound measurement of thyroid volume is not routinely performed in children without suspected thyroid disorders. However, pediatricians must be aware of the normal thyroid volume values in children in order to recognize...

  • Interesting Images
  • Open Access
1 Citations
951 Views
8 Pages

A Rare and Atypical Manifestation of Intraosseous Hemangioma in the Zygomatic Bone

  • Evagelos Kalfarentzos,
  • Efthymios Mavrakos,
  • Kamil Nelke,
  • Andreas Kouroumalis,
  • Gerasimos Moschonas,
  • Argyro Mellou,
  • Anastasia Therapontos and
  • Christos Perisanidis

Intraosseous hemangiomas (IH) are rare intrabony lesions that represent less than 1% of intraosseous tumors. IH are mostly seen in the axial skeleton and skull. Most commonly, the frontal bone, zygomatic, sphenoid, maxilla, ethmoid, and lacrimal bone...

  • Article
  • Open Access
642 Views
17 Pages

Background/Objectives: Ultrasound imaging is widely employed to assess kidney health and diagnose renal diseases. Accurate segmentation of renal structures in ultrasound images plays a critical role in the diagnosis and treatment of related kidney di...

  • Editorial
  • Open Access
1 Citations
743 Views
4 Pages

In recent years, radiology has become a key factor in sports clinical decision-making, primarily due to two parallel trends: the need for timely imaging in elite sports and the increase in recreational and weekend exercise-related injuries among indi...

  • Article
  • Open Access
1,170 Views
13 Pages

A Novel Serum-Based Bioassay for Quantification of Cancer-Associated Transformation Activity: A Case–Control and Animal Study

  • Aye Aye Khine,
  • Hsuan-Shun Huang,
  • Pao-Chu Chen,
  • Chun-Shuo Hsu,
  • Ying-Hsi Chen,
  • Sung-Chao Chu and
  • Tang-Yuan Chu

Background/Objectives: The detection of ovarian cancer remains challenging due to the lack of reliable serum biomarkers that reflect malignant transformation rather than mere tumor presence. We developed a novel biotest using an immortalized human fa...

  • Article
  • Open Access
1 Citations
936 Views
16 Pages

HMGB1 Deficiency Occurs in a Broad Range of Human Cancers and Is Often Associated with Unfavorable Tumor Phenotype

  • Viktoria Chirico,
  • Hena Sharifi,
  • Maria Christina Tsourlakis,
  • Seyma Büyücek,
  • Clara Marie von Bargen,
  • Katharina Möller,
  • Florian Lutz,
  • David Dum,
  • Martina Kluth and
  • Claudia Hube-Magg
  • + 19 authors

Background/Objectives: Aberrant expression of high-mobility group protein B1 (HMGB1) has been linked to cancer development and progression. Methods: To better comprehend the role of HMGB1 expression in cancer, a tissue microarray containing 14,966 sa...

  • Review
  • Open Access
1,174 Views
18 Pages

The Role of Imaging in Ventricular Tachycardia Ablation

  • Pasquale Notarstefano,
  • Michele Ciabatti,
  • Carmine Marallo,
  • Mirco Lazzeri,
  • Aureliano Fraticelli,
  • Valentina Tavanti,
  • Giulio Zucchelli,
  • Angelica La Camera and
  • Leonardo Bolognese

Ventricular tachycardia (VT) remains a major cause of morbidity and mortality in patients with structural heart disease. While catheter ablation has become a cornerstone in VT management, recurrence rates remain substantial due to limitations in elec...

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Diagnostics - ISSN 2075-4418