You are currently viewing a new version of our website. To view the old version click .

Diagnostics, Volume 15, Issue 14

July-2 2025 - 107 articles

Cover Story: Our study evaluated the clinical Oncuria 10‑Plex bladder cancer urine assay across three Luminex xMAP platforms—FlexMap 3D, Luminex 200, and MagPix—in an expanded cohort of 181 subjects (54 with confirmed bladder cancer). The assay demonstrated excellent reproducibility, with near-identical quantification for all biomarkers, strong correlation (R2 ≥ 0.995 for 27/30 analyte comparisons), and low variability (%CV ≤ 2.3% for 9/10 biomarkers). These results confirm that Oncuria provides reliable, multiplex-based bladder cancer detection and monitoring, independent of the instrument platform. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (107)

  • Review
  • Open Access
1 Citations
1,651 Views
12 Pages

Navigating Hyperhemolysis in Sickle Cell Disease: Insights from Literature

  • Sruthi Vellanki,
  • Nishanth Thalambedu,
  • Anup Kumar Trikannad Ashwini Kumar,
  • Sravya Vellanki,
  • Medhavi Honhar,
  • Rachel Hendrix,
  • Denese Harris,
  • Mamatha Gaddam,
  • Sunny R. K. Singh and
  • Shivi Jain
  • + 3 authors

Sickle cell disease (SCD) is a prevalent genetic disorder caused by a mutation in the beta-globin gene. Hyperhemolysis (HS) is a severe complication involving the rapid destruction of both transfused and endogenous red blood cells, commonly found in...

  • Article
  • Open Access
756 Views
12 Pages

Background/Objectives: The increased accessibility of information has resulted in a rise in patients trying to self-diagnose and opting for self-medication, either as a primary treatment or as a supplement to medical care. Our objective was to evalua...

  • Article
  • Open Access
994 Views
11 Pages

Analytical and Clinical Validation of the ConfiSign HIV Self-Test for Blood-Based HIV Screening

  • Hyeyoung Lee,
  • Ae-Ran Choi,
  • Hye-Sun Park,
  • JoungOk Kim,
  • Seo-A Park,
  • Seungok Lee,
  • Jaeeun Yoo,
  • Ji Sang Yoon,
  • Sang Il Kim and
  • Yoon Hee Jun
  • + 3 authors

Background/Objectives: Since the World Health Organization (WHO) recommended HIV self-testing as an alternative to traditional facility-based testing in 2016, it has been increasingly adopted worldwide. This study aimed to evaluate the performance of...

  • Article
  • Open Access
1,229 Views
10 Pages

Background/Objectives: For aging men experiencing lower urinary tract symptoms (LUTS), bladder diaries (BD) and uroflowmetry (UFM) are commonly used non-invasive diagnostic tools. However, bladder diaries often suffer from subjectivity and incomplete...

  • Article
  • Open Access
742 Views
12 Pages

Intergrader Agreement on Qualitative and Quantitative Assessment of Diabetic Retinopathy Severity Using Ultra-Widefield Imaging: INSPIRED Study Report 1

  • Eleonora Riotto,
  • Wei-Shan Tsai,
  • Hagar Khalid,
  • Francesca Lamanna,
  • Louise Roch,
  • Medha Manoj and
  • Sobha Sivaprasad

Background/Objectives: Discrepancies in diabetic retinopathy (DR) grading are well-documented, with retinal non-perfusion (RNP) quantification posing greater challenges. This study assessed intergrader agreement in DR evaluation, focusing on qualitat...

  • Article
  • Open Access
749 Views
16 Pages

Background/Objectives: This study examines the effectiveness of train-time computation, test-time computation, and their combination on the performance of large language modeling applied to an electronic medical record quality management system. It i...

  • Review
  • Open Access
1 Citations
1,888 Views
24 Pages

Deep Learning Network Selection and Optimized Information Fusion for Enhanced COVID-19 Detection: A Literature Review

  • Olga Adriana Caliman Sturdza,
  • Florin Filip,
  • Monica Terteliu Baitan and
  • Mihai Dimian

The rapid spread of COVID-19 increased the need for speedy diagnostic tools, which led scientists to conduct extensive research on deep learning (DL) applications that use chest imaging, such as chest X-ray (CXR) and computed tomography (CT). This re...

  • Review
  • Open Access
728 Views
27 Pages

This update is aimed at various specialists who deal with fractures, such as emergency physicians, general practitioners, orthopedists, and sports medicine physicians. The Global Burden of Disease 2019 Fracture Collaborators estimated the worldwide i...

  • Article
  • Open Access
1,780 Views
10 Pages

Alopecia Areata Associated with Dupilumab: National Database Study

  • Tarun Sontam,
  • Humaira Nfn,
  • Jodi Yanking Li,
  • Sehar Nadeem,
  • Katie Beier,
  • Neil K. Jairath and
  • Vignesh Ramachandran

Background: Alopecia areata (AA), an autoimmune condition causing non-scarring hair loss, often coexists with atopic dermatitis (AD) due to shared T-helper cell type 2 (Th2)-mediated pathways. Dupilumab, a monoclonal antibody inhibiting IL-4 and IL-1...

  • Article
  • Open Access
640 Views
15 Pages

Ocular Structural and Vascular Changes in Patients with Severe Asymptomatic Carotid Disease After Undergoing Carotid Endarterectomy (CEA) and Carotid Artery Stenting (CAS)

  • Foteini Xanthou,
  • Anna Dastiridou,
  • Athanasios Giannoukas,
  • Miltiadis Matsagkas,
  • Chara Tzavara,
  • Athanasios Chaidoulis,
  • Sofia Androudi and
  • Evangelia E. Tsironi

Background/Objectives: This study aimed to prospectively assess the incidence of retinal embolization and to evaluate the vascular and structural changes in the retina and choroid in 52 patients with asymptomatic severe carotid artery disease who und...

of 11

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Diagnostics - ISSN 2075-4418Creative Common CC BY license