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Cells, Volume 8, Issue 6

June 2019 - 127 articles

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Cover Story: HSP90s interact with and modulate several cellular signaling pathways involved in the regulation of metabolic key players and have a crucial role in the management of the subtle equilibrium between glycolysis and mitochondrial OXPHOS in response to tumor environmental fluctuations. In addition, HSP90s regulate epigenetic gene expression in a direct or indirect manner, both at intracellular and/or extracellular level. In the context of human cancer, emerging evidence supports the interplay between epigenetic mechanisms and metabolic reprogramming. Due to chaperoning activity, HSP90s contribute to the phenotypic plasticity of cancer cells at different levels and represent a hub for the crosstalk between metabolism and epigenetics in cancers. View this paper.

Articles (127)

  • Article
  • Open Access
22 Citations
5,066 Views
19 Pages

Relationship between Multiple Sclerosis-Associated IL2RA Risk Allele Variants and Circulating T Cell Phenotypes in Healthy Genotype-Selected Controls

  • Sophie Buhelt,
  • Helle Bach Søndergaard,
  • Annette Oturai,
  • Henrik Ullum,
  • Marina Rode von Essen and
  • Finn Sellebjerg

25 June 2019

Single nucleotide polymorphisms (SNPs) in or near the IL2RA gene, that encodes the interleukin-2 (IL-2) receptor α (CD25), are associated with increased risk of immune-mediated diseases including multiple sclerosis (MS). We investigated how the...

  • Article
  • Open Access
18 Citations
5,236 Views
14 Pages

Activation of Slit2/Robo1 Signaling Promotes Tumor Metastasis in Colorectal Carcinoma through Activation of the TGF-β/Smads Pathway

  • Yuying Yao,
  • Zijun Zhou,
  • Liuyou Li,
  • Junchen Li,
  • Lixun Huang,
  • Jiangchao Li,
  • Cuiling Qi,
  • Lingyun Zheng,
  • Lijing Wang and
  • Qian-Qian Zhang

25 June 2019

Slit2 (slit guidance ligand 2), a ligand of the Roundabout1 (Robo1) transmembrane receptor, is often overexpressed in colorectal carcinomas (CRCs). In this study, we performed data mining in the Metabolic gEne RApid Visualizer (MERAV) database and fo...

  • Article
  • Open Access
29 Citations
8,496 Views
17 Pages

BMP2 and TGF-β Cooperate Differently during Synovial-Derived Stem-Cell Chondrogenesis in a Dexamethasone-Dependent Manner

  • Nikolas J. Kovermann,
  • Valentina Basoli,
  • Elena Della Bella,
  • Mauro Alini,
  • Christoph Lischer,
  • Hagen Schmal,
  • Eva Johanna Kubosch and
  • Martin J. Stoddart

25 June 2019

Recent studies highlighting mesenchymal stem cell (MSC) epigenetic memory suggest that a different differentiation medium may be required depending on the tissue of origin. As synovial-derived stem cells (SDSCs) attract interest we aimed to investiga...

  • Feature Paper
  • Review
  • Open Access
44 Citations
10,502 Views
16 Pages

Targeting the Oncogenic FGF-FGFR Axis in Gastric Carcinogenesis

  • Jinglin Zhang,
  • Patrick M. K. Tang,
  • Yuhang Zhou,
  • Alfred S. L. Cheng,
  • Jun Yu,
  • Wei Kang and
  • Ka Fai To

25 June 2019

Gastric cancer (GC) is one of the most wide-spread malignancies in the world. The oncogenic role of signaling of fibroblast growing factors (FGFs) and their receptors (FGFRs) in gastric tumorigenesis has been gradually elucidated by recent studies. T...

  • Article
  • Open Access
75 Citations
7,684 Views
19 Pages

25 June 2019

Mitochondria-associated ER membranes (MAMs) are crucial for lipid transport and synthesis, calcium exchange, and mitochondrial functions, and they also act as signaling platforms. These contact sites also play a critical role in the decision between...

  • Review
  • Open Access
96 Citations
13,491 Views
21 Pages

Molecular Mechanisms of Microglial Motility: Changes in Ageing and Alzheimer’s Disease

  • Diana K. Franco-Bocanegra,
  • Ciaran McAuley,
  • James A. R. Nicoll and
  • Delphine Boche

25 June 2019

Microglia are the tissue-resident immune cells of the central nervous system, where they constitute the first line of defense against any pathogens or injury. Microglia are highly motile cells and in order to carry out their function, they constantly...

  • Article
  • Open Access
69 Citations
6,166 Views
16 Pages

24 June 2019

Patient-derived mesenchymal stromal cells (MSCs) play a key role in bone tissue engineering. Various donor-specific factors were identified causing significant variability in the biological properties of MSCs impairing quality of data and inter-study...

  • Article
  • Open Access
12 Citations
4,603 Views
15 Pages

23 June 2019

Induced brown adipocytes (also referred to as beige cells) execute thermogenesis, as do the classical adipocytes by consuming stored lipids, being related to metabolic homeostasis. Treatment of phytochemicals, including berberine (BBR), was reported...

  • Review
  • Open Access
13 Citations
14,083 Views
11 Pages

Role of Lipid Rafts in Hematopoietic Stem Cells Homing, Mobilization, Hibernation, and Differentiation

  • Munther Alomari,
  • Dana Almohazey,
  • Sarah Ameen Almofty,
  • Firdos Alam Khan,
  • Mohammad Al hamad and
  • Deena Ababneh

22 June 2019

Hematopoietic stem cells (HSCs) are multipotent, self-renewing cells that can differentiate into myeloid or lymphoid cells. The mobilization and differentiation processes are affected by the external environment, such as extracellular matrix and solu...

  • Article
  • Open Access
7 Citations
3,989 Views
17 Pages

miR-26a-5p is a Stable Reference Gene for miRNA Studies in Chondrocytes from Developing Human Cartilage

  • Enrico Ragni,
  • Paola De Luca,
  • Antongiulio Marmotti and
  • Laura de Girolamo

22 June 2019

miRNAs are emerging as key regulators of complex biological systems in several developmental processes. qRT-PCR is a powerful tool to quantitatively assess the profiles and modulation of miRNA expression. In the emerging field of cartilage maturation...

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