Table of Contents
Cells, Volume 8, Issue 6 (June 2019)
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Cover Story (view full-size image) HSP90s interact with and modulate several cellular signaling pathways involved in the regulation of [...] Read more. HSP90s interact with and modulate several cellular signaling pathways involved in the regulation of metabolic key players and have a crucial role in the management of the subtle equilibrium between glycolysis and mitochondrial OXPHOS in response to tumor environmental fluctuations. In addition, HSP90s regulate epigenetic gene expression in a direct or indirect manner, both at intracellular and/or extracellular level. In the context of human cancer, emerging evidence supports the interplay between epigenetic mechanisms and metabolic reprogramming. Due to chaperoning activity, HSP90s contribute to the phenotypic plasticity of cancer cells at different levels and represent a hub for the crosstalk between metabolism and epigenetics in cancers. View this paper.