Table of Contents
Cells, Volume 8, Issue 5 (May 2019)
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Cover Story (view full-size image) Skin is the largest organ of the human body. Its architecture and physiological functions depend on [...] Read more. Skin is the largest organ of the human body. Its architecture and physiological functions depend on diverse populations of epidermal cells and dermal fibroblasts. Reciprocal communication between the epidermis and dermis plays a key role in skin development, homeostasis, and repair. While several stem cell populations have been identified in the epidermis with distinct locations and functions, there is additional heterogeneity within the mesenchymal cells of the dermis. In our review, we discuss the current knowledge of how the Hippo pathway and other signaling cues regulate the activities of the transcriptional co-activators YAP and TAZ to control maintenance, activation, and coordination of the epidermal and dermal cell populations during skin development, homeostasis, wound healing, and cancer. View this paper.