Special Issue "ABC Transporters: From Basic Functions to Diseases"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 10 September 2019
ATP-binding cassette (ABC) transporters constitute one of the largest superfamilies of integral membrane proteins, play crucial roles in the transport of various kinds of endogenous metabolites such as bile acids, sterols, lipids, and peptides, and exogenous molecules such as antibiotics, toxins, and drugs. A number of studies in this field have revealed that several of these transporters were mutated in human disorders such as Tangier disease, Stargardt disease and progressive familial intrahepatic cholestasis, as well as contributing to multi-drug resistances in cancer chemotherapy. In addition, evidence has recently accumulated showing that single nucleotide polymorphisms (SNPs) in the transporter genes determine the pharmacokinetics of various drugs and contribute to the development of various diseases. Thus, understanding of the clinical impacts of ABC transporters will provide us with potential targets for the prognosis and treatment of various diseases.
We invite authors to submit original research as well as review articles that will help in our understanding of the impacts of ABC transporters and their gene polymorphisms on human health, including the pathogenesis of multifactorial disorder such as metabolic diseases and the pharmacokinetics of drugs and multi-drug resistance in cancer chemotherapy. This Special Issue will improve our understanding of ABC transporters and also pave the way for alternative therapeutic strategies and the development of diagnostic and therapeutic approaches for some disease treatments.
Dr. Hiroshi Nakagawa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- ATP-binding cassette (ABC) transporter
- drug resistance
- genetic polymorphism
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
1. Type: Article
Tentative title: Untranslated regions in ABC genes
Authors: Pavel Dvorak and Pavel Soucek (Charles University in Prague)
Abstract: In eukaryotes, untranslated regions that bracket protein coding regions of genes play a pivotal role in gene expression regulation especially on the translation regulation level. Experimental as well as bioinformatics studies revealed different kinds of functionally relevant sequences localized within untranslated regions. Disruption of these hot spots by congenital as well as acquired mutations can lead to serious clinical consequences. Although untranslated regions were well studied in many genes, with important discoveries, the information regarding these regions within the ABC gene family is scarce and worth further exploration. Moreover, whole exon sequencing approaches often ignore untranslated regions and leave them out of their scope. We will focus on this topic in our proposed article.