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Special Issue "Tumor Microenvironment: Interaction and Metabolism"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (15 April 2019).
Laboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health (LIH), L-1526 Luxembourg City, Luxembourg
Interests: hypoxia; tumor immune response; natural killer; cytotoxic T lymphocytes; autophagy; cancer immunotherapy; immune checkpoint blockades; immune infiltration
Cancer cells evolve in the tumor microenvironment, which is now well established as an integral part of the tumor and a determinant player in cancer cell adaptation and resistance to anti-cancer therapies. Cancer progression is now considered to be largely influenced by the tumor microenvironment, which is not only composed of proliferating cancer cells but also of stromal cells, blood vessels and endothelial cells, infiltrating immune cells, and a variety of associated tissue cells. In addition, factors in the tumor microenvironment, including hypoxia, play a key role in cancer progression, metastasis, and resistance to therapies. Therefore, tumor cells rewire their metabolic properties to shape hypoxic stress, resist anti-cancer therapies, and escape the immune system. Such cancer cell adaptations can be executed autonomously or through interactions with other cells in the tumor microenvironment. In this regard, it has become clear that anti-cancer therapies can be more effective by combining with agents that target key factors in the tumor microenvironment in order to suppress resistance mechanisms associated with the complexity of the tumor microenvironment. Elaborating such combination therapies remains very challenging, since it relies on better knowledge of the interaction between cancer cells and their tumor microenvironment. The aim of this Special Issue is to provide a comprehensive review covering the most recent developments in our understanding of the impact of the tumor microenvironment on tumor development and metabolic adaptation. By focusing on the most effective current therapeutic strategies to target pathways, molecules, metabolites, and components in the tumor microenvironment, the goal of this issue is to provide an overview on strategies that can be considered to overcome a hostile tumor microenvironment and elaborate a more favourable tumor microenvironment to support anti-cancer therapies.
Dr. Bassam Janji
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- tumor microenvironment
- stromal cells
- immune cells
- metabolic switch
- tumor cell plasticity
- tumor vasculature