Toxins, Volume 12, Issue 9 (September 2020) – 81 articles
Cover Story (view full-size image):
The emergence of B. cereus as a food-borne and clinical pathogen has intensified the need to distinguish strains of public health concern. Several toxins are involved in virulence, but there are currently no biological markers able to differentiate pathogenic from harmless strains. we report a structure/function characterization of CwpFM here, a cell wall peptidase involved in B. cereus virulence. CwpFM is shown as an exported endopeptidase composed of 3 Src Homology 3 domains and 1 catalytic NLPC_P60 domain. Remarkably, CwpFMs from pathogenic strains harbor three substitutions and a specific intrinsically disordered domain, inserted between SH3b3 and NLPC_P60 domain. This strongly suggests that such a linker is a marker of differentiation between B. cereus strains. Our findings improve our understanding of the pathogenicity of B. cereus while advancing both clinical diagnosis and food
[...] Read more.
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
- You may sign up for e-mail alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader
to open them.
Previous Issue
Next Issue