Special Issue "Molecular Basis and the Pathogenesis of Enterohemorrhagic Escherichia coli Infections"
Deadline for manuscript submissions: closed (30 September 2019).
Interests: food and feed-borne pathogens; Escherichia coli; ergot alkaloids
Special Issues and Collections in MDPI journals
Shiga toxin-producing Escherichia coli (STEC) are food-borne pathogens implicated in sporadic as well as national and international outbreaks of disease. Cattle and other ruminants are identified reservoirs of these organisms, which are erratically shed in feces. Although cattle are colonized with a diverse population of STEC, a relatively small proportion has been linked to human disease. A central question is how best to conclusively identify Escherichia coli that will lead to human disease. The abundance and persistence of Escherichia coli strains in animal hosts and the environment have been proposed as factors affecting the likelihood of strain pathogenicity, but what factors contribute to strain abundance and persistence? What virulence or other factors determine the pathogenicity of Escherichia coli? In addition, the genetic plasticity of Escherichia coli leading to the loss or gain of Shiga toxins and other virulence factors increases the difficulty of identifying potential pathogens, especially among non-O157 E. coli.
The focus of this Special Issue of Toxins will be on the pathogenicity of enterohemorrhagic Escherichia coli including: factors increasing the survival, abundance or persistence in the environment or animal hosts; the molecular basis of infections; molecular or other assays for the detection of E. coli causing disease; possible interventions to decrease the production of Shiga toxins or other virulence factors and control disease. The ultimate aim would be a reduction in future STEC outbreaks and improved outcomes for STEC patients.
Dr. Kim Stanford
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Enterohemorrhagic Escherichia coli
- Shiga toxins
- virulence factors
- environmental persistence
- human infection