Special Issue "Toxin-antitoxin (TA) systems"
Deadline for manuscript submissions: 30 April 2019
Bacterial toxin–antitoxin (TA) systems are ubiquitous modules found in almost all sequenced bacterial genomes. They consist of two genes, one encoding a stable toxin, whose overexpression kills the cell or causes growth stasis, and the other encoding an unstable antitoxin that neutralizes toxin action. To date, four different TA systems are known. Whereas in type I and III TA systems, the antitoxin is a small RNA, in type II and IV systems, toxins and antitoxins are proteins. In addition, two single instances have been reported as type V and type VI TA modules, both with proteinaceous toxins and antitoxins. Toxins are small polypeptides that use a variety of molecular mechanisms to inhibit essential cellular processes, such as cell division, DNA replication, translation or membrane integrity. Although toxin targets are known in many instances, their identification is still a challenging issue.
So far, three major biological functions of TA modules have been discovered, post-segregational killing ("plasmid addiction"), abortive infection (bacteriophage immunity through altruistic suicide), and persister formation (antibiotic tolerance through dormancy). Other functions have been proposed, but have not yet been experimentally supported. Many genomes carry multiple TA systems that frequently employ different mechanisms of growth inhibition.
This Special Issue will focus on the discovery and biological functions of new TA systems of all types, the characterization of toxins and the identification of their cellular targets, as well as regulatory mechanisms used by the corresponding antitoxins.
Dr. Sabine Brantl
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Toxin–antitoxin systems
- Postsegregational killing
- Abortive infection
- Persister formation