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Nutrients, Volume 17, Issue 5

March-1 2025 - 191 articles

Cover Story: Ultra-processed foods (UPFs) represent a widely consumed food category in modern diets. However, their impact on gut health has increasingly been raising concerns. This review investigates how UPFs impact the gut microbiome and gut barrier, emphasizing gut dysbiosis and increased gut permeability. UPFs, characterized by a high content of synthetic additives and emulsifiers and a low fiber content, are associated with a decrease in microbial diversity, lower levels of beneficial bacteria like Akkermansia muciniphila and Faecalibacterium prausnitzii, and an increase in pro-inflammatory microorganisms. These alterations in the microbial community contribute to persistent inflammation, which is associated with various chronic disorders including metabolic syndrome, irritable bowel syndrome, type 2 diabetes, and colorectal cancer. View this paper
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Articles (191)

  • Article
  • Open Access
3 Citations
2,497 Views
27 Pages

Targeted Sodium Acetate Liposomes for Hepatocytes and Kupffer Cells: An Oral Dual-Targeted Therapeutic Approach for Non-Alcoholic Fatty Liver Disease Alleviation

  • Yichao Hou,
  • Xilong Gao,
  • Jiahui Gong,
  • Xinrui Dong,
  • Yanling Hao,
  • Zhengyuan Zhai,
  • Hao Zhang,
  • Ming Zhang,
  • Rong Liu and
  • Ran Wang
  • + 1 author

6 March 2025

Background/Objectives: Sodium acetate (NaA) has demonstrated potential in improving non-alcoholic fatty liver disease (NAFLD) by targeting hepatocytes and Kupffer cells. However, its clinical application is hindered by low oral bioavailability and in...

  • Article
  • Open Access
6,083 Views
23 Pages

The Short- and Long-Term Effects of a Short Course of Sauerkraut Supplementation on the Gut Microbiota of Active Athletes: A Pilot Follow-Up Study

  • Jadran Zonjić,
  • Andrija Karačić,
  • Ivona Brodić,
  • Antonio Starčević,
  • Ira Renko,
  • Željko Krznarić,
  • Matija Ivančić,
  • Ana-Marija Liberati Pršo and
  • Zvonimir Šatalić

6 March 2025

Objectives: The application of whole fermented foods in sports nutrition for gut microbiota personalization is a promising area of investigation. Sauerkraut, a traditional fermented food, has not been extensively studied in this context. This study a...

  • Article
  • Open Access
1 Citations
1,851 Views
26 Pages

6 March 2025

Background/Objectives: Improving food safety practices among young adults is critical to public health, but effective communication strategies are under-researched. This study investigated the effectiveness of a 12-day message-based intervention to p...

  • Article
  • Open Access
2 Citations
1,862 Views
11 Pages

Nutritional Status and Its Impact on Treatment Tolerance in Non-Small-Cell Lung Cancer Patients Receiving Osimertinib

  • Claudia Barca-Díez,
  • Regina Palmeiro-Carballa,
  • Susana Castro-Luaces,
  • Maria Susana Fortes-González,
  • Silvia Vazquez-Blanco,
  • Noemi Martínez-López-De-Castro and
  • Natividad Lago-Rivero

6 March 2025

Background/Objectives: Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases and is a leading cause of morbidity and mortality worldwide. Between 35% and 65% of NSCLC patients experience nutritional problems or ma...

  • Article
  • Open Access
1 Citations
3,248 Views
20 Pages

Precision Medicine in Cardiovascular Disease Prevention: Clinical Validation of Multi-Ancestry Polygenic Risk Scores in a U.S. Cohort

  • Małgorzata Ponikowska,
  • Paolo Di Domenico,
  • Alessandro Bolli,
  • George Bartholomew Busby,
  • Emma Perez and
  • Giordano Bottà

6 March 2025

Background: Polygenic risk score (PRS) quantifies the cumulative effects of common genetic variants across the genome, including both coding and non-coding regions, to predict the risk of developing common diseases. In cardiovascular medicine, PRS en...

  • Article
  • Open Access
1 Citations
1,478 Views
19 Pages

Evaluating the Components, Nutrients, and Antioxidant and Anti-Inflammatory Properties of Centranthera grandiflora Benth Extracts

  • Wenjuan Yuan,
  • Xinlan Liu,
  • Xinting Wang,
  • Zejin Nian,
  • Xiaoyun Wu,
  • Chengting Zi,
  • Sha Xu,
  • Xiaojing Shen and
  • Xuanjun Wang

6 March 2025

Background: Centranthera grandiflora Benth is commonly utilized in China to take advantage of its purported health benefits. Methods: Here, the chemical composition, nutritional value, and bioactivity of C. grandiflora Benth extract (CGE) are charact...

  • Perspective
  • Open Access
4 Citations
5,268 Views
11 Pages

Potential Roles of Exogenous Proteases and Lipases as Prebiotics

  • Yongshou Yang,
  • Thanutchaporn Kumrungsee,
  • Yukako Okazaki,
  • Toshiro Watanabe,
  • Junji Inoue,
  • Takafumi Iguchi,
  • Shinji Fukuda,
  • Manabu Kuroda,
  • Kyoichi Nishio and
  • Shotaro Yamaguchi
  • + 1 author

6 March 2025

Digestive enzymes, such as proteases and lipases, are widely recognized for their crucial roles in the ripening and production of fermented foods. Digestive enzymes are also used as supplements in nonruminant livestock to enhance feed digestion and p...

  • Article
  • Open Access
6 Citations
3,144 Views
14 Pages

Milk Exosome-Based Delivery System for Probiotic Encapsulation That Enhances the Gastrointestinal Resistance and Adhesion of Probiotics

  • Linlin Hao,
  • Yinxue Liu,
  • Ignatius Man-Yau Szeto,
  • Haining Hao,
  • Tai Zhang,
  • Tongjie Liu and
  • Huaxi Yi

6 March 2025

The oral administration of probiotics is a promising strategy to regulate the host–intestinal flora balance and improve health. Nevertheless, adverse gastrointestinal (GI) conditions affect the activity of free native probiotics. In this study,...

  • Article
  • Open Access
1,622 Views
20 Pages

Host Transcriptome and Microbial Variation in Relation to Visceral Hyperalgesia

  • Christopher J. Costa,
  • Stephanie Prescott,
  • Nicolaas H. Fourie,
  • Sarah K. Abey,
  • LeeAnne B. Sherwin,
  • Bridgett Rahim-Williams,
  • Paule V. Joseph,
  • Hugo Posada-Quintero,
  • Rebecca K. Hoffman and
  • Wendy A. Henderson

6 March 2025

Background: Chronic visceral hypersensitivity is associated with an overstressed pain response to noxious stimuli (hyperalgesia). Microbiota are active modulators of host biology and are implicated in the etiology of visceral hypersensitivity. Object...

  • Article
  • Open Access
1 Citations
1,882 Views
20 Pages

6 March 2025

Background: This study aimed to investigate genetic variants associated with the estimated glomerular filtration rate (eGFR) and their interactions with lifestyle factors and bioactive compounds in large hospital-based cohorts, assessing their impact...

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Nutrients - ISSN 2072-6643