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Nutrients
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Impact of Nutritional Supplementation on Cognition and Neuroinflammation
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Impact of Nutritional Supplementation on Cognition and Neuroinflammation

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Neuro Sciences".

Deadline for manuscript submissions: 25 May 2025 | Viewed by 4299

Special Issue Editor

Dr. Rui Wang

E-Mail Website
Guest Editor
Department of Physical Activity and Health, The Swedish School of Sport and Health Sciences, GIH, Lidingövägen 1, P.O. Box 5626, SE-114 86 Stockholm, Sweden
Interests: neurodegeneration; nutrition intervention; cognitive aging; Alzheimer’s disease and dementia; behavioural patterns; daily movements; body–brain connection; cardiovascular health; heart–brain axis; cerebral small vessel diseases

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit scientific articles to this Special Issue of Nutrients, entitled “Impact of Nutritional Supplementation on Cognition and Neuroinflammation”.

Cognitive decline is a common aspect of the aging process, and growing evidence suggests that neuroinflammation is involved in cognitive aging and the progression of diseases such as Alzheimer’s disease. A balanced diet, combined with a healthy lifestyle, has been shown to support brain health, extend life expectancy, and delay the onset of neurodegenerative disorders. However, the efficiency of nutrient absorption decreases with age and can be impacted by the use of medications. This makes the role of nutritional supplementation, particularly in the context of cognitive aging and neuroinflammation, an area that requires further research.

This Special Issue aims to provide a platform for discussing innovative research related to the impact of nutritional supplementation, cognition, and neuroinflammation. I extend my gratitude to all contributors, reviewers, and the editorial team for their dedication to making this Special Issue a success.

Dr. Rui Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cognitive aging
  • dementia
  • neurodegeneration
  • Alzheimer’s disease
  • neuroinflammation
  • blood–brain barrier
  • oxidative stress
  • neuroimmune response
  • inflammatory pathways
  • dietary supplements
  • nutrient absorption
  • vitamins and minerals
  • nutritional deficiency
  • dietary patterns
  • probiotics and prebiotics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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14 pages, 1860 KiB  
Article
Anti-Stress Effects of Tremella fuciformis Berk. Enzymatic Extracts: A Preclinical Study
by Gahye Moon, Nodir Rustamov, Junhang Park, Hanseul Park, Kumju Park, Eun Hye Choi and Yoon-Seok Roh
Nutrients 2025, 17(5), 914; https://doi.org/10.3390/nu17050914 - 6 Mar 2025
Viewed by 922
Abstract
Background/Objectives: Chronic stress disrupts neurochemical balance, triggers inflammation, and compromises neuronal integrity, contributing to the development of stress-related disorders. This study aimed to evaluate the preventative effects of Tremella fuciformis Berk (TF) enzymatic extracts on chronic restraint stress (CRS)-induced behavioral, neurochemical, and inflammatory [...] Read more.
Background/Objectives: Chronic stress disrupts neurochemical balance, triggers inflammation, and compromises neuronal integrity, contributing to the development of stress-related disorders. This study aimed to evaluate the preventative effects of Tremella fuciformis Berk (TF) enzymatic extracts on chronic restraint stress (CRS)-induced behavioral, neurochemical, and inflammatory dysfunctions in mice. Methods: Male C57BL/6N mice were administered TF at doses of 50 mg/kg and 100 mg/kg daily via oral gavage for 21 days during CRS exposure. Behavioral assessments, including anxiety and depression-like behavior tests, were conducted. Neurochemical and inflammatory markers were analyzed using PCR and ELISA, while histological examinations of hippocampal regions were performed to assess neuronal integrity. In vitro assays evaluated neuronal cell viability, protection against corticosterone (CORT)-induced cytotoxicity, and inhibition of monoamine oxidase (MAO) activity. Results: TF supplementation alleviated CRS-induced weight loss, normalized serum CORT levels, increased locomotor activity, reduced immobility time, and decreased anxiety-like behaviors. TF upregulated brain-derived neurotrophic factor (BDNF) mRNA, downregulated pro-inflammatory markers (CXCL2, iNOS, IFNG), and mitigated neuronal apoptosis in the hippocampus. In vitro, TF improved neuronal cell viability, protected against CORT-induced cytotoxicity, and significantly inhibited MAO activity, particularly MAO-A. Conclusions: These findings demonstrate the neuroprotective and anti-stress effects of Tremella fuciformis Berk enzymatic extracts, supporting its potential as a natural therapeutic intervention for stress-related disorders. Full article
(This article belongs to the Special Issue Impact of Nutritional Supplementation on Cognition and Neuroinflammation)
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14 pages, 613 KiB  
Article
Selenium and Episodic Memory: The Moderating Role of Apolipoprotein E ε4
by Shin Gyeom Kim, Musung Keum, Young Min Choe, Guk-Hee Suh, Boung Chul Lee, Hyun Soo Kim, Jun Hyung Lee, Jaeuk Hwang, Dahyun Yi and Jee Wook Kim
Nutrients 2025, 17(3), 595; https://doi.org/10.3390/nu17030595 - 6 Feb 2025
Viewed by 1033
Abstract
Background: Selenium (Se), a vital trace element, plays a neuroprotective role by mitigating oxidative stress through selenoproteins and regulating metal balance. The apolipoprotein E ε4 allele (APOE4), a significant genetic risk factor for Alzheimer’s disease (AD), has been linked to reduced Se levels [...] Read more.
Background: Selenium (Se), a vital trace element, plays a neuroprotective role by mitigating oxidative stress through selenoproteins and regulating metal balance. The apolipoprotein E ε4 allele (APOE4), a significant genetic risk factor for Alzheimer’s disease (AD), has been linked to reduced Se levels and weakened antioxidant capacity. This research explores the association between serum Se concentrations and cognitive performance, with an emphasis on how APOE4 status influences this relationship. Methods: This study included 196 older adults from community and memory clinic settings, who underwent assessments for episodic memory, global cognition, and non-memory functions using the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) neuropsychological battery, with serum selenium levels analyzed via inductively coupled plasma–mass spectrometry (ICP-MS) and APOE genotyping conducted to determine allele status. Results: Higher serum Se levels were associated with better episodic memory score (EMS) (B = 0.065, 95% CI = 0.020–0.110, p = 0.005) and CERAD total score (TS) (B = 0.119, 95% CI = 0.046–0.193, p = 0.002). However, the interaction between Se and APOE4 status significantly affected EMS (B = −0.074, 95% CI = −0.109 to −0.039, p < 0.001), with significant benefits observed in APOE4-negative participants. Conclusions: This study highlights the genotype-specific impact of Se on cognitive health, emphasizing the need for personalized nutritional interventions targeting Se levels, particularly for APOE4-negative individuals. Future research should further elucidate the mechanisms of Se’s effects and assess its therapeutic potential in aging populations. Full article
(This article belongs to the Special Issue Impact of Nutritional Supplementation on Cognition and Neuroinflammation)
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Review

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24 pages, 1118 KiB  
Review
Dietary Patterns and Migraine: Insights and Impact
by Yi-Hsien Tu, Ching-Mao Chang, Cheng-Chia Yang, I-Ju Tsai, Ying-Chen Chou and Chun-Pai Yang
Nutrients 2025, 17(4), 669; https://doi.org/10.3390/nu17040669 - 13 Feb 2025
Viewed by 2045
Abstract
Migraine is a prevalent neurological disorder characterized by significant disability and triggered by various factors, including dietary habits. This review explores the complex relationship between diet and migraine, highlighting both triggering and protective roles of dietary patterns and specific nutrients. Evidence suggests that [...] Read more.
Migraine is a prevalent neurological disorder characterized by significant disability and triggered by various factors, including dietary habits. This review explores the complex relationship between diet and migraine, highlighting both triggering and protective roles of dietary patterns and specific nutrients. Evidence suggests that certain foods, such as alcohol, caffeine, chocolate, MSG, nitrates, and tyramine, can trigger migraines in susceptible individuals. Conversely, dietary interventions, including carbohydrate-restricted diets, ketogenic diets, vitamin D3 supplementation, omega-3 fatty acids, Mediterranean dietary patterns, and increased water intake, have shown potential in reducing migraine frequency and severity. Observational studies also indicate that maintaining a healthy diet, rich in fruits and vegetables and low in processed foods, is associated with better migraine outcomes. The effectiveness of these interventions varies among individuals, underscoring the importance of personalized approaches. Future studies should further explore the role of diet in migraine management, focusing on randomized trials to establish causality and refine dietary recommendations for patients. Full article
(This article belongs to the Special Issue Impact of Nutritional Supplementation on Cognition and Neuroinflammation)
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