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Prebiotics and Probiotics in Metabolism Disorder—2nd Edition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics and Probiotics".

Deadline for manuscript submissions: 5 June 2025 | Viewed by 1347

Special Issue Editor

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Interests: prebiotics and probiotics; gut microbiota; nutrition; immunology; metabolic diseases; gut–brain axis; gastrointestinal diseases; endocrine disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microbial community structural and functional disorder (dysbiosis) has been linked to numerous diseases, including diabetes mellitus, obesity, cardiovascular disease, gastrointestinal disorders, mental disease, and cancer. The use of prebiotics or probiotic bacteria is a promising means to disease prevention and treatment. The introduced probiotic strains pass through the digestive tract or accumulate at a specific site in the intestine, producing an abundance of metabolites, inhibiting pathogen colonization, regulating immunity, and, together with prebiotics, positively modulating the balance of gut bacterial composition and its metabolites, thus exerting beneficial effects. Prebiotic or probiotic supplementation, aimed at preventing the disruption of microbial communities, represents an alternative health regulation strategy. Studies have revealed that the consumption of prebiotics and probiotic supplementation, and the resulting improvement in gut microbiota dysbiosis, significantly improves the overall health of patients with diabetes and metabolic diseases. This Special Issue covers all aspects of using prebiotics and probiotics to treat diabetes and metabolism disorder in humans and model organisms (mammals, other vertebrates, and invertebrates). The aim of this Special Issue is to provide a platform for all researchers to better understand the importance of prebiotics and probiotics as therapeutic strategies for diabetes and metabolism disorder.

Dr. Gang Wang
Guest Editor

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Keywords

  • diabetes
  • metabolism disorder
  • probiotics
  • prebiotics
  • gut microbiota
  • nutrition
  • obesity

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Published Papers (1 paper)

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Research

14 pages, 2395 KiB  
Article
Milk Exosome-Based Delivery System for Probiotic Encapsulation That Enhances the Gastrointestinal Resistance and Adhesion of Probiotics
by Linlin Hao, Yinxue Liu, Ignatius Man-Yau Szeto, Haining Hao, Tai Zhang, Tongjie Liu and Huaxi Yi
Nutrients 2025, 17(5), 923; https://doi.org/10.3390/nu17050923 - 6 Mar 2025
Viewed by 1182
Abstract
The oral administration of probiotics is a promising strategy to regulate the host–intestinal flora balance and improve health. Nevertheless, adverse gastrointestinal (GI) conditions affect the activity of free native probiotics. In this study, a novel probiotic encapsulation system based on milk exosomes (mExos) [...] Read more.
The oral administration of probiotics is a promising strategy to regulate the host–intestinal flora balance and improve health. Nevertheless, adverse gastrointestinal (GI) conditions affect the activity of free native probiotics. In this study, a novel probiotic encapsulation system based on milk exosomes (mExos) and DSPE-PEG-PBA was developed. mExos acted as a shield to protect probiotics from harsh GI environments, and DSPE-PEG-PBA served as a bridge between mExos and probiotics. The coated probiotics were characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), and intrinsic fluorescence spectra. The results showed three probiotics (Akkermansia muciniphila (AKK), Bifidobacterium animalis subsp. lactis BB-12 (BB12), and Lactiplantibacillus plantarum Q7 (Q7)) were coated with mExos@DSPE-PEG-PBA, with encapsulation rates of 90.37 ± 0.45%, 84.47 ± 1.22%, and 70.93 ± 2.39%, respectively. This encapsulation not only preserved the growth activity of the probiotics but also provided robust protection against the detrimental effects of acidic pH, bile salts, and digestive enzymes. The encapsulated strains Q7, BB12, and AKK demonstrated survival rates of 80.99 ± 0.41%, 85.28 ± 0.20%, and 94.53 ± 0.26%, respectively, in an in vitro simulated GI environment. The mExos@DSPE-PEG-PBA-encapsulated probiotics exhibited enhanced hydrophobicity and auto-aggregation capacity, accompanied by a significant improvement in mucoadhesive properties, which collectively potentiated their colonization potential within the gastrointestinal tract. These findings substantiate the potential of mExos as an encapsulation platform for probiotics, providing valuable insights into the selection of exosomes as encapsulating agents to enhance probiotic viability and mucoadhesive capacity. Full article
(This article belongs to the Special Issue Prebiotics and Probiotics in Metabolism Disorder—2nd Edition)
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