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Vitamin A and Pregnancy: A Narrative Review

Maternal and Child Healthcare Postgraduate Program, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife 50070-550, Pernambuco, Brazil
Department of Obstetrics and Gynecology, Lauro Wanderley University Hospital, Federal University of Paraíba (UFPB), João Pessoa 58059-900, Paraíba, Brazil
Department of Maternal and Child Healthcare, Federal University of Pernambuco (UFPE), Recife 50670-901, Pernambuco, Brazil
Biological and Health Sciences Center, Catholic University of Pernambuco (UNICAP), Recife 50050-900, Pernambuco, Brazil
Coordination of the Nursing Mentoring Program, Faculdade Pernambucana de Saúde (FPS), Recife 51180-001, Pernambuco, Brazil
Department of Nursing, Regional University of Cariri (URCA), Crato 63105-000, Ceará, Brazil
Research Directorate, IMIP, Recife 50070-550, Pernambuco, Brazil
Author to whom correspondence should be addressed.
Nutrients 2019, 11(3), 681;
Received: 27 February 2019 / Revised: 15 March 2019 / Accepted: 19 March 2019 / Published: 22 March 2019
Vitamin A is a crucial micronutrient for pregnant women and their fetuses. In addition to being essential for morphological and functional development and for ocular integrity, vitamin A exerts systemic effects on several fetal organs and on the fetal skeleton. Vitamin A requirements during pregnancy are therefore greater. Vitamin A deficiency (VAD) remains the leading cause of preventable blindness in the world. VAD in pregnant women is a public health issue in most developing countries. In contrast, in some developed countries, excessive vitamin A intake during pregnancy can be a concern since, when in excess, this micronutrient may exert teratogenic effects in the first 60 days following conception. Routine prenatal vitamin A supplementation for the prevention of maternal and infant morbidity and mortality is not recommended; however, in regions where VAD is a public health issue, vitamin A supplementation is recommended to prevent night blindness. Given the importance of this topic and the lack of a complete, up-to-date review on vitamin A and pregnancy, an extensive review of the literature was conducted to identify conflicting or incomplete data on the topic as well as any gaps in existing data. View Full-Text
Keywords: Vitamin A; vitamin A deficiency; pregnancy Vitamin A; vitamin A deficiency; pregnancy
MDPI and ACS Style

Bastos Maia, S.; Rolland Souza, A.S.; Costa Caminha, M.d.F.; Lins da Silva, S.; Callou Cruz, R.d.S.B.L.; Carvalho dos Santos, C.; Batista Filho, M. Vitamin A and Pregnancy: A Narrative Review. Nutrients 2019, 11, 681.

AMA Style

Bastos Maia S, Rolland Souza AS, Costa Caminha MdF, Lins da Silva S, Callou Cruz RdSBL, Carvalho dos Santos C, Batista Filho M. Vitamin A and Pregnancy: A Narrative Review. Nutrients. 2019; 11(3):681.

Chicago/Turabian Style

Bastos Maia, Sabina, Alex S. Rolland Souza, Maria d.F. Costa Caminha, Suzana Lins da Silva, Rachel d.S.B.L. Callou Cruz, Camila Carvalho dos Santos, and Malaquias Batista Filho. 2019. "Vitamin A and Pregnancy: A Narrative Review" Nutrients 11, no. 3: 681.

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