Table of Contents
Nutrients, Volume 10, Issue 4 (April 2018)
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Cover Story (view full-size image) Here meta-analysis and experimental data demonstrate a link between protein biosynthesis impairment [...] Read more. Here meta-analysis and experimental data demonstrate a link between protein biosynthesis impairment and neurodegeneration such as Alzheimer’s disease (AD). Protein biosynthesis reduces at step of tRNA aminoacylation in AD patients. Inhibitors of tryptophanyl-tRNA synthetase (TrpRS), an enzyme of protein biosynthesis cause such decrease. Gut microbiome produce TrpRS inhibitors - tryptamine, tryptophanol and indoleacetic acid. Tryptamine and tryptophanol induce neurotoxicity and formation of fibrillary tangles similar to those detected in AD brain. Monoamine oxidases (MAO) degrade tryptamine into indoleacetic acid. Tryptamine presents in food. Dietary supplements and antibiotics can increase tryptamine content in stool. Tryptamine easily crosses blood-brain barrier and induces pathology in brain blood vessels. Combination of high tryptamine with MAO inhibitors prescribed as anti-depressants can be lethal. View this paper