Serum Hepcidin Concentration in Individuals with Sickle Cell Anemia: Basis for the Dietary Recommendation of Iron
AbstractDietary iron requirements in patients with sickle cell disease (SCD) remain unclear. SCD is a neglected hemoglobinopathy characterized by intense erythropoietic activity and anemia. Hepcidin is the hormone mainly responsible for iron homeostasis and intestinal absorption. Intense erythropoietic activity and anemia may reduce hepcidin transcription. By contrast, iron overload and inflammation may induce it. Studies on SCD have not evaluated the role of hepcidin in the presence and absence of iron overload. We aimed to compare serum hepcidin concentrations among individuals with sickle cell anemia, with or without iron overload, and those without the disease. Markers of iron metabolism and erythropoietic activity such as hepcidin, ferritin, and growth differentiation factor 15 were evaluated. Three groups participated in the study: the control group, comprised of individuals without SCD (C); those with the disease but without iron overload (SCDw); and those with the disease and iron overload (SCDio). Results showed that hepcidin concentration was higher in the SCDio > C > SCDw group. These data suggest that the dietary iron intake of the SCDio group should not be reduced as higher hepcidin concentrations may reduce the intestinal absorption of iron. View Full-Text
Share & Cite This Article
Omena, J.; Cople-Rodrigues, C.D.S.; Cardoso, J.D.A.; Soares, A.R.; Fleury, M.K.; Brito, F.D.S.B.; Koury, J.C.; Citelli, M. Serum Hepcidin Concentration in Individuals with Sickle Cell Anemia: Basis for the Dietary Recommendation of Iron. Nutrients 2018, 10, 498.
Omena J, Cople-Rodrigues CDS, Cardoso JDA, Soares AR, Fleury MK, Brito FDSB, Koury JC, Citelli M. Serum Hepcidin Concentration in Individuals with Sickle Cell Anemia: Basis for the Dietary Recommendation of Iron. Nutrients. 2018; 10(4):498.Chicago/Turabian Style
Omena, Juliana; Cople-Rodrigues, Cláudia D.S.; Cardoso, Jessyca D.A.; Soares, Andrea R.; Fleury, Marcos K.; Brito, Flávia D.S.B.; Koury, Josely C.; Citelli, Marta. 2018. "Serum Hepcidin Concentration in Individuals with Sickle Cell Anemia: Basis for the Dietary Recommendation of Iron." Nutrients 10, no. 4: 498.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.