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Marine Drugs, Volume 23, Issue 9

September 2025 - 37 articles

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Cover Story: Glycolipids are an important class of marine natural products with potential for sustainable bioproduct manufacturing. Their amphiphilicity and structure-dependent bioactivities underpin applications in nutraceuticals, pharmaceuticals, and cosmetics. Yet their discovery and development remain limited due to the laboriousness of extraction and characterisation from complex biomasses. This review summarises advanced analytical approaches tailored to different glycolipid subclasses, covering methods of extraction/enrichment and TLC-based rapid detection, alongside LC–MS/MS methodologies for high-throughput structural characterisation. These methods enable rapid profiling of bioactive and functional glycolipid structures to support bioproduct development from a diverse range of marine biomasses including seaweeds, fish, and shellfish. View this paper

Articles (37)

  • Article
  • Open Access
552 Views
19 Pages

Synthesis and Biological Evaluation of Marine-Inspired Benzothiazole Derivatives as Retinoid X Receptor-α Antagonists with Anti-Cancer Activities

  • Yingting Lin,
  • Ming Peng,
  • Renjing Yang,
  • Guanghui Wang,
  • Junjie Chen,
  • Rong Ding,
  • Cuiling Sun,
  • Wenjing Tian and
  • Haifeng Chen

21 September 2025

Retinoid X receptor α (RXRα) plays a vital role in multiple biological and pathological processes and represents a promising therapeutic target for anti-tumor drug design. Inspired by the marine-derived RXRα antagonist meroterpenthi...

  • Article
  • Open Access
650 Views
27 Pages

Meat Nutritional Value and Exoskeleton Valorisation of Callinectes sapidus from Three Sites of Biological and Ecological Interest in Morocco: Scientific Insights Toward a Management Strategy in the Mediterranean Sea

  • Kamal Gourari,
  • Youness Mabrouki,
  • Abdelkhaleq Fouzi Taybi,
  • Abdessadek Essadek,
  • Valentina Tanduo,
  • Fabio Crocetta,
  • Ilyesse Rahhou,
  • Chaouki Belbachir,
  • Lucia Rizzo and
  • Bouchra Legssyer

21 September 2025

Biological invasions threaten biodiversity worldwide. The American blue crab Callinectes sapidus Rathbun, 1896, among the Mediterranean’s most damaging invaders, takes up the challenge to transform this threat into gain. To turn its impact into...

  • Article
  • Open Access
524 Views
20 Pages

Effect of Precipitated Extracellular Marennine on Angiogenesis and Tumour Cell Proliferation

  • Mostefa Fodil,
  • Javier Muñoz-Garcia,
  • Amel-Khitem Benali,
  • Jasmina Rogozarski,
  • Virginie Mignon,
  • Honora Labrana,
  • Anna Lokajczyk,
  • Pamela Pasetto,
  • Jean-Luc Mouget and
  • Catherine Boisson-Vidal
  • + 1 author

19 September 2025

Angiogenesis is a fundamental biological process involved in the formation of new blood vessels from the pre-existing vascular network. In addition to physiological processes, angiogenesis is also implicated in pathological conditions such as tumour...

  • Review
  • Open Access
1,502 Views
63 Pages

19 September 2025

This review examines recent advances in the extraction of valuable compounds from seaweed biomass, focusing on practical feasibility and environmental sustainability. There is a growing importance of seaweed biomass in terms of the study and acknowle...

  • Article
  • Open Access
467 Views
18 Pages

Novel pH-Responsive PSS-Loaded Chitosan Matrix Nanoparticles Ameliorate Pressure Overload-Induced Cardiac Hypertrophy

  • Meijie Xu,
  • Zhen Fan,
  • Dingfu Wang,
  • Dan Li,
  • Haimiao Zou,
  • Yiting Xue,
  • Shixin Wang and
  • Chunxia Li

19 September 2025

Cardiac hypertrophy is a critical contributor to cardiac dysfunction and the development of heart failure, yet effective therapeutic strategies remain limited. Propylene glycol alginate sulfate sodium (PSS) is a marine sulfated polysaccharide drug us...

  • Review
  • Open Access
2,070 Views
23 Pages

Amyloid-like Structures in Marine Adhesive Proteins

  • Mariana Rodrigues Santos,
  • Bárbara Joana Henriques and
  • Romana Santos

19 September 2025

The formation of amyloid-like structures is commonly linked to neurodegenerative diseases, such as Parkinson’s and Alzheimer’s. However, proteins can form amyloid-like structures in non-pathological contexts, referred to as functional amy...

  • Article
  • Open Access
2,534 Views
23 Pages

Integrated Omics-Based Discovery of Bioactive Halogenated Metabolites from the Deep-Sea Streptomyces sp. B188M101

  • Emmanuel Tope Oluwabusola,
  • Stephen A. Jackson,
  • Cristina Brunati,
  • Stefanie Gackstatter,
  • Hannah Vedder,
  • Marianna Iorio,
  • Gargee Chawande,
  • Lekha Menon Margassery,
  • Giang-Son Nguyen and
  • David J. Clarke
  • + 3 authors

19 September 2025

Using the one-strain-many-compounds (OSMAC) culturing approach, metabolomic studies, and bioassay-guided purification, we have isolated and characterised three new chlorinated natural products, agelolines B-D (1–3), together with two known comp...

  • Article
  • Open Access
472 Views
13 Pages

19 September 2025

Porphyridium purpureum can synthesize a high phycoerythrin content, which has strong potential application in nutrition, pharmaceuticals, and cosmetics. An effective culture strategy is the key to producing biomass of P. purpureum rich in phycoerythr...

  • Article
  • Open Access
425 Views
15 Pages

Co-Culture of Auxenochlorella protothecoides and Serratia liquefaciens Promotes Lutein Accumulation

  • Weiwei Xue,
  • Zhen Li,
  • Yanhong Qiu,
  • Yong Ma,
  • Yongchang Xue,
  • Zongshen Zhang and
  • Changbin Liu

18 September 2025

Lutein, a crucial carotenoid with diverse biological roles, is in high demand in the market. Current production predominantly relies on plant extraction, which is hindered by low yield and seasonal limitations. Microalgae, such as Chlorella and Chlam...

  • Article
  • Open Access
815 Views
22 Pages

Contamination Characteristics of 21 PFAS in Shellfish and Crustaceans of Zhejiang Province and Exposure Risk Assessment for Adult Dietary Consumers

  • Hexiang Zhang,
  • Haoyi Zhang,
  • Ronghua Zhang,
  • Dong Zhao,
  • Bing Zhu,
  • Xiaojuan Qi,
  • Lili Chen,
  • Jiang Chen,
  • Jikai Wang and
  • Yibin Zheng
  • + 1 author

15 September 2025

This study investigated the occurrence, sources, and health risks of 21 per- and polyfluoroalkyl substances (PFAS) in commercially available shellfish and crustaceans from Zhejiang Province, China. Among the 306 samples analyzed, 87.9% contained at l...

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Mar. Drugs - ISSN 1660-3397Creative Common CC BY license