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Marine-Derived Polymers for Tissue Engineering and Drug Delivery Applications

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Biomaterials of Marine Origin".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 2645

Special Issue Editor


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Guest Editor
FunGlass–Centre for Functional and Surface Functionalized Glass, Alexander Dubček University of Trenčín, Trenčín, Slovakia
Interests: bioactive systems; biomedical applications; biopolymers; hierarchical scaffolds; hybrid platforms; mesoporous silica materials; multifunctional composites; SPIONs

Special Issue Information

Dear Colleagues,

The current challenges that humanity faces have led to the design and development of advanced materials with multiple properties that can address the variety and complexity of health problems from a more environmentally friendly perspective.

In this context, polymers/materials obtained from any marine source represent a significant advantage, not only due to their natural origin, which grants them excellent biocompatibility and degradability, but also due to their diverse properties, including antibacterial, bioactive, anticoagulant, antiviral, anti-inflammatory, mucoadhesive, and immunomodulatory effects, among others.

This Special Issue focuses on research on innovative systems based on marine-derived polymer products, alone or in combination with other polymers or inorganic materials, including their fabrication, characterization, and utilization, promoting their biomedical application, primarily in drug delivery and tissue engineering, as well as any other strategies to solve critical challenges in engineering and medicine. Therefore, original research articles (full articles and short communications), reviews, perspectives, and opinion pieces covering the most recent studies and advances are highly welcome.

Dr. Zulema Vargas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine polysaccharides
  • marine proteins and peptides
  • tissue engineering
  • drug delivery
  • biomedical applications
  • marine-derived polymeric materials:
    • manufacturing techniques for processing: 3D printing, freeze-drying, electrospinning, coating techniques, etc.
    • functionalization incorporation of new functional groups
    • composites and hybrid materials (organic/inorganic moieties)
    • design strategies: porous platforms, scaffolds, fibers, capsules, nanoparticles, films, coatings, etc.

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Published Papers (2 papers)

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Research

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18 pages, 3997 KB  
Article
Novel pH-Responsive PSS-Loaded Chitosan Matrix Nanoparticles Ameliorate Pressure Overload-Induced Cardiac Hypertrophy
by Meijie Xu, Zhen Fan, Dingfu Wang, Dan Li, Haimiao Zou, Yiting Xue, Shixin Wang and Chunxia Li
Mar. Drugs 2025, 23(9), 365; https://doi.org/10.3390/md23090365 - 19 Sep 2025
Viewed by 448
Abstract
Cardiac hypertrophy is a critical contributor to cardiac dysfunction and the development of heart failure, yet effective therapeutic strategies remain limited. Propylene glycol alginate sulfate sodium (PSS) is a marine sulfated polysaccharide drug used in the treatment of cardiovascular diseases and has shown [...] Read more.
Cardiac hypertrophy is a critical contributor to cardiac dysfunction and the development of heart failure, yet effective therapeutic strategies remain limited. Propylene glycol alginate sulfate sodium (PSS) is a marine sulfated polysaccharide drug used in the treatment of cardiovascular diseases and has shown cardiac function benefits. Here, we designed a pH-responsive PSS-loaded nanoparticle drug delivery system. It was self-assembled by negatively charged PSS with positively charged trimethyl chitosan glycocholic acid (TMC-GA) via electrostatic interaction, and further stabilized the nanoparticles with Hydroxypropyl methylcellulose phthalate (HP55) excipients. The prepared TMC-GA/HP55@PSS nanoparticles were spherical, with a mean particle size of 361.5 ± 1.26 nm, zeta potential of −30.3 ± 0.9 mV, and encapsulation efficiency of 92.52 ± 2.4%. In vitro release study demonstrated the pH-responsive property of TMC-GA/HP55@PSS under intestinal conditions and facilitated nanoparticles absorption in the intestinal epithelium. In vitro experiments confirmed the biocompatibility of PSS and its ability to improve myocardial cell hypertrophy. In vivo, both PSS and its nanoparticles significantly ameliorated pressure overload–induced cardiac hypertrophy in mice, with TMC-GA/HP55@PSS exhibiting better cardioprotective efficacy. This study is the first to integrate pH-responsiveness and bile acid transport-mediated uptake into PSS nanocarrier systems. The findings provide valuable data and enlightenment for designing novel formulations and expanding the clinical applications of PSS. Full article
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Review

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26 pages, 4285 KB  
Review
Progress in the Application of Marine Polysaccharide Drug Delivery Systems in Tumor Immunotherapy: Multiple Mechanisms and Material Forms
by Mingxue Cha, Shuqiang Yan, Yiping Zhang and Peipei Wang
Mar. Drugs 2025, 23(10), 384; https://doi.org/10.3390/md23100384 - 27 Sep 2025
Viewed by 753
Abstract
Tumor immunotherapy, a revolutionary cancer treatment, is hindered by inadequate immune cell activation, immunosuppressive tumor microenvironment (TME), and off-target toxicities of immunotherapeutics. These bottlenecks necessitate innovative strategies to enhance efficacy and reduce side effects. Marine polysaccharides have garnered significant attention due to their [...] Read more.
Tumor immunotherapy, a revolutionary cancer treatment, is hindered by inadequate immune cell activation, immunosuppressive tumor microenvironment (TME), and off-target toxicities of immunotherapeutics. These bottlenecks necessitate innovative strategies to enhance efficacy and reduce side effects. Marine polysaccharides have garnered significant attention due to their potential to enhance immune cell activity and regulate the tumor microenvironment, among other benefits. Due to their excellent biocompatibility, modifiability, and relatively low cost, polysaccharides are increasingly being explored as materials for drug delivery systems. The development of marine polysaccharide-based drug delivery systems represents an opportunity for advancing tumor immunotherapy. This review focuses on the application of marine polysaccharide drug delivery systems in tumor immunotherapy, exploring the mechanisms underlying the bioactivity of marine polysaccharides, the design of drug delivery systems, and the interactions between these systems and tumor immunotherapy, aiming to provide a framework for advancing marine polysaccharide-based therapeutics, accelerating the clinical translation of effective, safe, and targeted tumor immunotherapy strategies. Full article
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