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Marine Bioactive Peptides: Structure, Function, and Therapeutic Potential, 5th Edition

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 794

Special Issue Editor


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Guest Editor
M.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, The Russian Academy of Sciences, Moscow 117997, Russian
Interests: marine natural products; marine peptides; innate immunity; host defense peptides; molecular mechanisms of antimicrobial and anticancer activity; structure elucidation; structure-function relationship; bioengineering; drug design; peptide antibiotics; peptide anticancer agents; drug resistance; bioorganic chemistry; biotechnology
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Special Issue Information

Dear Colleagues,

The Special Issue "Marine Bioactive Peptides: Structure, Function, and Therapeutic Potential, 5th Edition" aims to collect papers on up-to-date information regarding isolation, structural elucidation, functional characterization, and therapeutic potential evaluation of peptides isolated from marine organisms. Chemical synthesis and biotechnological production of marine peptides and their mimetics will also be a focus of this Special Issue. In addition, this Special Issue has an interest in publishing new results arising from a peptidomic approach. Diverse in structure and function, marine peptides were found in various phyla, and their number has dynamically grown in recent years. Some of them are evolutionary ancient molecular factors of innate immunity that play a key role in host defense. A plethora of biological activities, including antibacterial, antifungal, antiviral, cytotoxic, neurotoxic, anticoagulant, antifreeze, endotoxin-binding, and immune-modulating, make marine peptides an attractive molecular basis for the design of innovative antibiotics, anticancer drugs, analgetics, medicines for neurological disorders, etc.

As Guest Editor, I invite researchers in the field to contribute to the fifth edition entitled "Marine Bioactive Peptides: Structure, Function, and Therapeutic Potential, 5th Edition".

Prof. Dr. Tatiana V. Ovchinnikova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine peptides
  • structure, function
  • chemical synthesis
  • biotechnological production
  • peptidomics
  • therapeutic potential
  • antibacterial
  • antifungal
  • antiviral
  • cytotoxic
  • neurotoxic
  • anticancer
  • anticoagulant
  • endotoxin-binding
  • host defense
  • innate immunity
  • toxins
  • peptide drugs

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Published Papers (1 paper)

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Research

21 pages, 3929 KB  
Article
Heterologous Expression and Antimicrobial Targets of a Novel Glycine-Rich Antimicrobial Peptide from Artemia franciscana
by Ming Tao, Aobo Sun, Huishi Shao, Huaiyuan Ye, Guangming Yu, Daigeng Chen and Wei Zhang
Mar. Drugs 2025, 23(8), 330; https://doi.org/10.3390/md23080330 - 17 Aug 2025
Viewed by 607
Abstract
The growing problem of antimicrobial resistance in aquaculture, caused by the excessive and unregulated use of antibiotics, highlights the critical necessity for developing new anti-infective solutions. Based on the characteristics of glycine-rich antimicrobial peptides (AMPs) and transcriptomic data, an antimicrobial peptide, namely Af [...] Read more.
The growing problem of antimicrobial resistance in aquaculture, caused by the excessive and unregulated use of antibiotics, highlights the critical necessity for developing new anti-infective solutions. Based on the characteristics of glycine-rich antimicrobial peptides (AMPs) and transcriptomic data, an antimicrobial peptide, namely AfRgly1, was discovered in this study. Subsequently, the peptide was obtained through heterologous expression in E. coli, and its antibacterial spectrum was determined. Molecular dynamics simulation and molecular biology experiments were conducted to explore the antibacterial target of AfRgly1. Results showed that the mRNA expression level of AfRgly1 was significantly upregulated after Vibrio alginolyticus infection. AfRgly1 has broad-spectrum antibacterial activity targeting on bacterial cell membrane, and it may also interact with bacterial DNA. AfRgly1 displayed low selectivity for fish red blood cells. These results indicate that AfRgly1 is an antimicrobial peptide with considerable potential for application in the development of therapeutic agents. Full article
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