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Marine Bioactive Substances: From By-Products to Innovative Applications

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 794

Special Issue Editors


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Guest Editor
College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China
Interests: food science; food flavor; seafood processing
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
College of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China
Interests: algae; polysaccharide; antioxidant; anti-inflammatory

Special Issue Information

Dear Colleagues,

Marine bioactive substances have emerged as a treasure trove of novel functional components. Peptides, polysaccharides, lipids, enzymes, and other secondary metabolites exhibit remarkable bioactivities such as antioxidant, immunomodulatory, anticancer, and metabolic regulatory properties. Particularly in the fishery and aquaculture industries, a large amount of by-products (e.g., fish skin, fish scales, viscera, minced meat, shells, and seaweed residues) are often discarded, which not only wastes resources but may also trigger environmental problems. The development of advanced extraction and modification technologies will help promote future development and application of marine bioactive substances in functional foods, pharmaceutical products, and cosmetics, and presenting a path to the sustainable development of marine resources.

This Special Issue invites relevant original research papers and review papers that focus on the extraction, purification, biological activity, and function of natural bioactive substances from marine biological resources, aiming to deeply understand the research concepts and latest achievements in marine bioactive substances.

Dr. Wenzheng Shi
Prof. Dr. Dandan Ren
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • biological activity
  • peptide
  • protein hydrolysates
  • extract methods
  • molecular structures
  • functional characteristics
  • by-product utilization
  • bioaccessibility and bioavailability

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Published Papers (1 paper)

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Research

27 pages, 2810 KB  
Article
Meat Nutritional Value and Exoskeleton Valorisation of Callinectes sapidus from Three Sites of Biological and Ecological Interest in Morocco: Scientific Insights Toward a Management Strategy in the Mediterranean Sea
by Kamal Gourari, Youness Mabrouki, Abdelkhaleq Fouzi Taybi, Abdessadek Essadek, Valentina Tanduo, Fabio Crocetta, Ilyesse Rahhou, Chaouki Belbachir, Lucia Rizzo and Bouchra Legssyer
Mar. Drugs 2025, 23(9), 367; https://doi.org/10.3390/md23090367 - 21 Sep 2025
Viewed by 597
Abstract
Biological invasions threaten biodiversity worldwide. The American blue crab Callinectes sapidus Rathbun, 1896, among the Mediterranean’s most damaging invaders, takes up the challenge to transform this threat into gain. To turn its impact into economic value and guide control efforts, we analysed separately [...] Read more.
Biological invasions threaten biodiversity worldwide. The American blue crab Callinectes sapidus Rathbun, 1896, among the Mediterranean’s most damaging invaders, takes up the challenge to transform this threat into gain. To turn its impact into economic value and guide control efforts, we analysed separately the meat composition and exoskeleton biopolymers of adult crabs from three Moroccan protected Sites of Biological and Ecological Interest: Marchica Lagoon (S1), Moulouya Estuary (S2), and Al Hoceima National Park (S3). Marchica specimens exhibited the highest protein content (21.87 ± 1.15 g 100 g−1, p < 0.001) and an elevated lipid fraction, yielding nutrient-dense meat suitable for premium markets. Moulouya crabs were noted for their taste potential, with a higher concentration of fat (1.73 ± 0.09%) and carbohydrates (0.91 ± 0.1%). Al Hoceima individuals displayed markedly mineralised exoskeletons producing lean and low-fat meat, valued in dietary applications. Exoskeleton organic-to-mineral (OM/MM) ratios and proximate composition revealed three adaptive profiles, opportunistic (S1), acclimatory (S2), and conservative (S3), presumably correlated to local salinity, productivity, and substrate conditions, underscoring the species’ phenotypic plasticity. X-ray diffraction confirmed the α-chitin polymorph, while FTIR analysis indicated degrees of deacetylation consistent with high-purity chitosan. These findings support the development of a site-specific circular economy framework and may contribute to the ecological resilience of Morocco’s protected coastal areas. Full article
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