Journal Menu► ▼ Journal Menu
Journal Browser► ▼ Journal Browser
Table of Contents
Mar. Drugs, Volume 15, Issue 10 (October 2017)
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
- You may sign up for e-mail alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Cover Story (view full-size image) The Conus genus includes around 500 species of marine mollusks producing venomous peptides known as [...] Read more. The Conus genus includes around 500 species of marine mollusks producing venomous peptides known as Conotoxins classified into 16 superfamilies. Among these, µ-Conotoxins are potent and specific blockers of voltage-gated sodium channels, which consists of one α-subunit and two auxiliary β-subunits. The α-subunit comprised of four homologue domains (I-IV), each consisting of six transmembrane helices (S1–S6). Helices S5 and S6 form the channel pore while S1–S4 form the voltage sensor. β-subunits contain immunoglobulin-like folds. Sodium channels are responsible for the influx of sodium ions that generates the action potential in excitable cells. Hyperexcitability results in pain perception and transmission. The μ-conotoxins bind the pore region of sodium channels preventing ion conductance, so they may represent potential analgesic compounds in the clinical management of pain conditions. View this paper