Marine Ice-binding Proteins and Their Mimetics: Structure, Function, and Application
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (30 April 2018) | Viewed by 10187
Special Issue Editors
Interests: cold-active enzymes; psychrophilic proteins; ice-binding proteins; antifreeze proteins; cold-adaptation
Special Issues, Collections and Topics in MDPI journals
2. Department of Polar Sciences, Korea University of Science and Technology, Incheon, Republic of Korea
Interests: ice-binding proteins; antifreeze protein; structure and function of psychrophilic protein
Special Issue Information
Dear Colleagues,
Ice-binding proteins are a group of proteins that have affinity for ice. Antifreeze proteins, the most commonly-known terminology for this kind of protein, are a misnomer since they are actually a subset of ice-binding protein and some, not all, ice-binding proteins function as a biological antifreeze in physiological concentrations. In this Special Issue, we would like to use “ice-binding proteins” to include any proteins that have affinity for ice, such as antifreeze proteins, ice nucleation proteins, ice-recrystallization inhibition proteins, and ice-interacting proteins.
Since the fish antifreeze proteins were first identified in the late 1960s, the number of ice-binding proteins identified from marine organisms has been continuously increasing. Currently, ice-binding proteins are found in bacteria, fungi, microalgae, and crustaceans inhabiting cold environments. Marine ice-binding proteins seem to possess characteristic ice-binding sites, despite their diversity in primary and tertiary structures. The ice-binding affinity is well manifested in their properties: Thermal hysteresis and ice-recrystallization inhibition. In addition, some ice-binding proteins appear to interact with biological membranes. These properties are of biotechnological interest for cryopreservation of valuable biological resources, such as stem cells.
This Special Issue, "Marine Ice-Binding Proteins and Their Mimetics: Structure, Function, and Applications", of Marine Drugs will cover, but is not limited to, reviews and recent results regarding the isolation and characterization of new marine ice-binding genes and proteins, structure determination, and application of ice-binding proteins, mimetic peptides and/or peptoids in various fields, such as cryopreservation and hypothermic storage.
Prof. Dr. Hak Jun Kim
Prof. Dr. Jun Hyuck Lee
Guest Editors
Manuscript Submission Information
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Keywords
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Marine ice-binding proteins
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Marine antifreeze proteins
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Marine antifreeze glycoproteins
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Marine antifreeze peptides
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Horizontal gene transfer
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Psychrophiles
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Peptidomimetics
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Ice-binding affinity
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Ice recrystallization inhibition
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Thermal hysteresis
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Membrane interaction
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X-ray structure
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NMR
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Molecular dynamics simulations
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Cryopreservation
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Vitrification
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Heterologous expression
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Gene organization
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