Anti-Inflammatory Cembranoids from the Soft Coral Lobophytum crassum
AbstractAbstract: Cembrane-type diterpenoids are among the most frequently encountered natural products from the soft corals of the genus Lobophytum. In the course of our investigation to identify anti-inflammatory constituents from a wild-type soft coral Lobophytum crassum, two new cembranoids, lobophyolide A (1) and B (2), along with five known compounds (3–7), were isolated. The structures of these natural products were identified using NMR and MS spectroscopic analyses. Compound 1 was found to possess the first identified α-epoxylactone group among all cembrane-type diterpenoids. The in vitro anti-inflammatory effect of compounds 1–5 was evaluated. The results showed that compounds 1–5 not only reduced IL-12 release, but also attenuated NO production in LPS-activated dendritic cells. Our data indicated that the isolated series of cembrane-type diterpenoids demonstrated interesting structural features and anti-inflammatory activity which could be further developed into therapeutic entities. View Full-Text
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Lai, K.-H.; You, W.-J.; Lin, C.-C.; El-Shazly, M.; Liao, Z.-J.; Su, J.-H. Anti-Inflammatory Cembranoids from the Soft Coral Lobophytum crassum. Mar. Drugs 2017, 15, 327.
Lai K-H, You W-J, Lin C-C, El-Shazly M, Liao Z-J, Su J-H. Anti-Inflammatory Cembranoids from the Soft Coral Lobophytum crassum. Marine Drugs. 2017; 15(10):327.Chicago/Turabian Style
Lai, Kuei-Hung; You, Wan-Jing; Lin, Chi-Chen; El-Shazly, Mohamed; Liao, Zuo-Jian; Su, Jui-Hsin. 2017. "Anti-Inflammatory Cembranoids from the Soft Coral Lobophytum crassum." Mar. Drugs 15, no. 10: 327.
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