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Mar. Drugs 2017, 15(10), 329;

Marine-Derived Penicillium Species as Producers of Cytotoxic Metabolites

College of Pharmacy, Pusan National University, Busan 609-735, Korea
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China
Author to whom correspondence should be addressed.
Received: 10 August 2017 / Revised: 30 September 2017 / Accepted: 9 October 2017 / Published: 24 October 2017


Since the discovery of penicillin, Penicillium has become one of the most attractive fungal genera for the production of bioactive molecules. Marine-derived Penicillium has provided numerous excellent pharmaceutical leads over the past decades. In this review, we focused on the cytotoxic metabolites * (* Cytotoxic potency was referred to five different levels in this review, extraordinary (IC50/LD50: <1 μM or 0.5 μg/mL); significant (IC50/LD50: 1~10 μM or 0.5~5 μg/mL); moderate (IC50/LD50: 10~30 μM or 5~15 μg/mL); mild (IC50/LD50: 30~50 μM or 15~25 μg/mL); weak (IC50/LD50: 50~100 μM or 25~50 μg/mL). The comparative potencies of positive controls were referred when they were available). produced by marine-derived Penicillium species, and on their cytotoxicity mechanisms, biosyntheses, and chemical syntheses. View Full-Text
Keywords: marine-derived Penicillium; natural products; cytotoxic metabolites; biosynthesis marine-derived Penicillium; natural products; cytotoxic metabolites; biosynthesis

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Liu, S.; Su, M.; Song, S.-J.; Jung, J.H. Marine-Derived Penicillium Species as Producers of Cytotoxic Metabolites. Mar. Drugs 2017, 15, 329.

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