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Mar. Drugs 2017, 15(10), 325;

Pleiotropic Role of Puupehenones in Biomedical Research

Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Málaga, Andalucía Tech, and IBIMA; E-29071 Málaga, Spain
Unidad 741 de CIBER “de Enfermedades Raras”, E-29071 Málaga, Spain
Author to whom correspondence should be addressed.
Received: 1 September 2017 / Revised: 27 September 2017 / Accepted: 16 October 2017 / Published: 21 October 2017
(This article belongs to the Collection Marine Compounds and Cancer)
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Marine sponges represent a vast source of metabolites with very interesting potential biomedical applications. Puupehenones are sesquiterpene quinones isolated from sponges of the orders Verongida and Dictyoceratida. This family of chemical compounds is composed of a high number of metabolites, including puupehenone, the most characteristic compound of the family. Chemical synthesis of puupehenone has been reached by different routes, and the special chemical reactivity of this molecule has allowed the synthesis of many puupehenone-derived compounds. The biological activities of puupehenones are very diverse, including antiangiogenic, antitumoral, antioxidant, antimicrobial, immunomodulatory and antiatherosclerotic effects. Despite the very important roles described for puupehenones concerning different pathologies, the exact mechanism of action of these compounds and the putative therapeutic effects in vivo remain to be elucidated. This review offers an updated and global view about the biology of puupehenones and their therapeutic possibilities in human diseases such as cancer. View Full-Text
Keywords: puupehenones; sponges; marine drugs; antiangiogenic; antitumoral puupehenones; sponges; marine drugs; antiangiogenic; antitumoral

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Martínez-Poveda, B.; Quesada, A.R.; Medina, M.Á. Pleiotropic Role of Puupehenones in Biomedical Research. Mar. Drugs 2017, 15, 325.

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