Molecules, Volume 5, Issue 12

The Fourth School for Young Scientists on Chemistry of Porphyrins and Related Compounds Ivanovo 2000 and the Symposium "Application of Porphyrins in Medicine" were held at the facilities of Ivanovo State University of Chemistry and Technology and the...

Gain a working knowledge of thermodynamics and kinetics with a minimum of mathematics—a guide for individuals in the biological sciences[...]

An accessible and easy-to-read text for students requiring a broad overview of the key techniques used to characterise the structure and function of complex biomacromolecules such as proteins and DNA.[...]

As we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry.[...]

Carbohydrate Chemistry and Glycobiology have witnessed a rapid expansion during the last few years with the development of numerous new, imaginative and efficient syntheses which provide further insight into structures and biological interactions of...

The use of Lewis acids in organic synthesis, especially in catalysis is one of the most rapidly developing fields in synthetic organic chemistry.[...]

The pharmaceutical industry - an important segment of the chemical industry - is technologically prolific.[...]

This book focuses on the theoretical problems associated with molecular diversity as it is being applied in the pharmaceutical industry.[...]

Since its original appearance in 1977, Advanced Organic Chemistry has found wide use as a text providing broad coverage of the structure, reactivity and synthesis of organic compounds.[...]

The use of ultrasound in chemistry – sonochemistry – has grown spectacularly in recent years, resulting in a significant body of empirical research.[...]

*Editor's Note: The brief summary and the contents of the books are reported as provided by the author or the publishers.[...]

To a mixture of 0.8 g (4.7 mmol) of metachloroperbenzoique acid (mCPBA) and 1.58g (18.8mmol) of sodium hydrogenocarbonate (NaHCO₃) in 15 ml of dichloromethane was added 1 g (2.35 mmol) of 1 in 5 ml of CH₂Cl₂.[...]

5-[o-(2-bromo-1-ethoxy)]phenyl-10,15,20-triphenylporphyrin (1) was prepared according to published method [1].[...]

As part of a research programme targeting novel molecules as potential anti-inflammatory agents we synthesised 3-Chloro-5-methoxy-1-benzo[b]thiophene-2-sulphonylamide base on the reported anti-inflammatory activity of the structurally related molecul...

In the course of our recent studies on the synthesis, solid phase structure, solution and solid phase ¹³C CPMAS [1], and its application in Ion Selective Electrodes [2] of the smallest benzo crown ether, Benzo-9-Crown-3, B9C3, we accomplished the syn...

The experimental procedure follows a novel protocol developed recently by us [1].[...]

The title compound was prepared from imidazolinone 1 whose synthesis as well as ¹H and ¹³C NMR spectra were published previously [1].[...]

To sodium hydride (0.3g, 12.7 mmole) carefully washed with anhydrous benzene under nitrogen (to eliminate mineral oil from the commercial product) [1], was added (0.8 ml, 8.43 mmole) of dimethylcarbonate (freshly distilled) in dry benzene (20 ml).[...]

Disulfides that mimic the pentapeptide Phe-D-Leu-Gly-D-Leu-Phe can be obtained in high yield from the corresponding thioacetate via the intermediate mercaptan by prolonged standing in alkali [1].[...]

Disulfides that mimic the pentapeptide Phe-Leu-Gly-Leu-Phe can be obtained in high yield from the corresponding thioacetate via the intermediate mercaptan by prolonged standing in alkali [1].[...]

Members of genus Swertia (Gentianaceae) have been the source of many active xanthones.[...]

Katritzky's well-established chemistry of benzotriazole [1] was applied to the synthesis of 1,2,3,4- tetrahydro-b-carboline, which have been traditionally prepared by Pictet-Spengler condensation², Fischer cyclisation and other methods³.[...]

5-(Indol-3-yl)barbituric acid 3 was prepared by knovenagel condensation of indol-3-carboxaldehyde 1 and barbituric acid 2 in ethanol using piperidine as a base [1,2].[...]

The title compound was obtained by dehydration of the corresponding diacid 1 (12.1 g, 55 mmol) by boiling in acetyl chloride (50 ml) for four hours.[...]

The experimental procedure follows the general synthesis of arylalkynes reported by Sonogashira [1].[...]

All the following operations were performed under an inert atmosphere using standard vacuum line techniques. Trimethyloxosulfonium iodide (2, 0.73 g, 3.3 mmol) [1] was suspended in anhydrous DMSO (6 mL) and sodium hydride (80 % suspension in mineral...

To the epoxide 1 (1 g, 2.32 mmol) in acetone (50 ml) [1] was added dropwise at 0°C a solution of CrO₃ (0.7 g, 7 mmol) in acetone (20 ml).[...]

To a mixture of (0.85 g, 4.9 mmol) of metachloroperoxybenzoic acid (mCPBA) [1,2] and (1.63 g, 19.6 mmol) of sodium hydrogenocarbonate (NaHCO₃) in 20 ml of dichloromethane was added (1 g, 2.42 mmol) of 1 in 10 ml of CH₂Cl₂.[...]

To sodium hydride (0.34 g, 13.96 mmole) carefully washed with anhydrous benzene under nitrogen (to eliminate mineral oil from the commercial product) [1], was added 0.8 ml (9.27 mmol) of dimethylcarbonate (freshly distilled) in dry benzene (20 ml).[...]

8-Dihydro-3-methyl-7-amino-[1,2,4]triazino[3,4-b][1,3,4]thiadiazine 2 was prepared by the cyclocondensation of 4-amino-6-methyl-3-thio-1,2,4-triazin-5-one 1 with chloro-acetonitrile in the presence of triethylamine in refluxing CH₃CN.[...]

3-(1-Butenone-3)indole 1 was prepared by previously published method [1].[...]

To a solution of 1g (2.27 mmol) of 1 in 40ml of chloroform at room temperature was added 0.55g (2.27 mmol) of meta-chloroperbenzoic acid (mCPBA).[...]

A three-component halogeno aldol reaction has been developed by using titanium tetrachloride as the halogen source as well as the Lewis acid mediator. The dehydration and elimination of hydrogen chloride were inhibited by conducting the reaction at 0...

Ab initio and DFT quantum chemical calculations have been applied to a study of the Diels-Alder reaction of o-benzoquinone as diene and norbornadiene as dienophile. Transition states for the different reactions are located and activation energies est...

Reaction of 3-(2-methylbenzimidazol-1-yl)propanoic acid hydrazide (1) with CS₂/KOH gave oxadiazole 2 which underwent Mannich reaction to give 3. Compound 2 was treated with hydrazine hydrate to give triazole 4 which was treated with both aldehydes an...

Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of...

Diastereofacial selectivity of the addition of organometallic reagents to 1,2-Oisopropylidene-O-R-α-D-xylopentodialdo-1,4-furanoses (6) was studied.

Quantum mechanical calculations were carried out to study the molecular geometry and electronic structure of 2-amino-2-desoxyglucopyranose (AG) and the Nacetyl-, N-ethanoyl-, series of N-phthalimidoalkanoyl-AG. The total charge density, electrostatic...

Quinones having hydroxy groups directly attached to the quinone ring constitute a very interesting class of quinoid compounds. A great number of hydroxyquinones are found in nature and the majority of them exhibit unique biological activity. Their sy...

This review reports some novel (or considerably improved) methods for the synthesis of aromatic iodides, (dichloroiodo)arenes, (diacetoxyiodo)arenes, iodylarenes and diaryliodonium salts, as well as some facile, oxidative anion metatheses in crude di...

The triplet sensitized cyclization of enyne-carbodiimide 4 leads to efficient formation of indoloquinoline 5 with concomittant loss of a methyl group. The efficient loss of the methyl group was explained using AM1 semiempirical calculations.

The redox potentials of 4,4’-dimethyl-N’N’-alkylidene bridged 2,2’-bipyridinium salts derivatives (DBPAs) can be controlled by changing the N, N’-alkylidene bridge length which changes the conformation of the DBPAs.. In this paper, the torsional angl...

A phytoalexin from papaya fruit has been synthesized in four steps; this procedure involved a Pummerer- type reaction.

The synthesis of 4-chloro-8-methylquinolin-2(1H)-one and its thione analogue is described. Some nucleophilic substitution reactions of the 4-chloro group were carried out to get new 4-substituted 2-quinolinones and quinolinethiones, such as 4-sulfany...

A mild and efficient catalytic method for synthesis of 5-alkoxycarbonyl-4-aryl-3,4- dihydropyrimidin-2(1H)-ones using KSF montmorillonite as catalyst is described.

Methods to reduce the carboxylic acid moiety in 3-carboxy-2,2,5,5-tetramethylpyrrolin-1-oxyl to an alcohol as an intermediate toward the corresponding aldehyde have been explored and an improved method has been developed.

A highly stereoselective enantiodivergent synthesis of non-racemic 3,3,3-trifluoroalanine 7 is reported. The methodology is based on the reduction, by 9-BBN or DIBAH, of the chiral sulfinimine 3 derived from ethyl trifluoropyruvate, followed by acidi...

We describe an improved synthetic strategy for the preparation of nucleic acid encoded peptide and protein libraries. A solid-phase format was used to prepare and purify a novel type of mRNA-template for in vitro mRNA-protein fusion synthesis. The pr...

Presented here is a method for rapidly testing the reactivity of carboxylic acids in amide-forming reactions. For this, a mixture of two acids, one a reference compound, and one acid whose reactivity is unknown, are coupled to an aminoacylated tetrak...

The α-keto methylene group in 3,5-diaryl-2-cyclohexenones 2 and 3,5-diarylcyclohexanones 8 have been used to obtain fused pyrazoles and isoxazoles. The new compounds were characterized by IR and ¹H-NMR spectral data.