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Open AccessArticle

Synthesis and Antimicrobial Activity of Some New Benzimidazole Derivatives

Therapeutical Chemistry Department. National Research Centre, Dokki, Cairo, Egypt
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Molecules 2000, 5(12), 1429-1438; https://doi.org/10.3390/51201429
Received: 10 January 2000 / Revised: 5 August 2000 / Accepted: 22 December 2000 / Published: 22 December 2000
Reaction of 3-(2-methylbenzimidazol-1-yl)propanoic acid hydrazide (1) with CS2/KOH gave oxadiazole 2 which underwent Mannich reaction to give 3. Compound 2 was treated with hydrazine hydrate to give triazole 4 which was treated with both aldehydes and acetic anhydride to give 5 and 6, respectively. Carbohydrazide 1 was reacted with ethyl acetoacetate, acetylacetone and aldehydes to give 7, 8 and 9, respectively. Cyclocondensation of 9 with thioglycolic and thiolactic acids gave 10 and 11, respectively. Some of these compounds showed potential antimicrobial activities. View Full-Text
Keywords: Methylbenzimidazole; oxadiazole; thioglycolic; thiolactic; triazole; pyrazole; antimicrobial Methylbenzimidazole; oxadiazole; thioglycolic; thiolactic; triazole; pyrazole; antimicrobial
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El-masry, A.H.; Fahmy, H.H.; Ali Abdelwahed, S.H. Synthesis and Antimicrobial Activity of Some New Benzimidazole Derivatives. Molecules 2000, 5, 1429-1438.

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