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Molecules, Volume 25, Issue 5

2020 March-1 - 240 articles

Cover Story: Organotin hydrides have demonstrated their potential to be used as building blocks for a great variety of organometallic compounds. Organotin hydrides with sterically shielding aryl substituents, in particular, have attracted special interest as these ligands can kinetically stabilize metastable products. As part of the Special issue “Organometallic Synthesis of Extremely Sensitive Compounds for Fundamental Investigations, Bond Activation, and Catalysis” with Guest Editor Dr. Burgert Blom, we present the synthesis of aryltin hydrides featuring a sterically encumbered aryl ligand, which exhibit enough steric protection to shield the tin hydrogen bond and make the isolated compounds more thermally stable and more tolerant towards oxygen. The steric potential is visualized on the cover. View this paper.
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Articles (240)

  • Review
  • Open Access
53 Citations
12,450 Views
13 Pages

10 March 2020

Liquid crystal polymers have attracted massive attention as stimuli-responsive shape memory materials due to their unique reversible large-scale and high-speed actuations. These materials can be utilized to fabricate artificial muscles, sensors, and...

  • Article
  • Open Access
31 Citations
7,519 Views
14 Pages

Unveiling the Molecular Basis of Mascarpone Cheese Aroma: VOCs analysis by SPME-GC/MS and PTR-ToF-MS

  • Vittorio Capozzi,
  • Valentina Lonzarich,
  • Iuliia Khomenko,
  • Luca Cappellin,
  • Luciano Navarini and
  • Franco Biasioli

10 March 2020

Mascarpone, a soft-spread cheese, is an unripened dairy product manufactured by the thermal-acidic coagulation of milk cream. Due to the mild flavor and creamy consistency, it is a base ingredient in industrial, culinary, and homemade preparations (e...

  • Article
  • Open Access
8 Citations
5,757 Views
14 Pages

10 March 2020

Here we sought to evaluate the contribution of the PBD unit to the biological activity of PBD-conjugates and, to this end, an adenosine nucleoside was attached to the PBD A-ring C8 position. A convergent approach was successfully adopted for the synt...

  • Article
  • Open Access
13 Citations
4,351 Views
19 Pages

10 March 2020

Phalaenopsis amabilis, one of the most important plants in the international flower market due to its graceful shape and colorful flowers, is an orchid that undergoes vernalization and requires low-temperature treatment for flowering. There have been...

  • Article
  • Open Access
51 Citations
7,125 Views
33 Pages

Identification of Novel Chemical Entities for Adenosine Receptor Type 2A Using Molecular Modeling Approaches

  • Kelton L. B. dos Santos,
  • Jorddy N. Cruz,
  • Luciane B. Silva,
  • Ryan S. Ramos,
  • Moysés F. A. Neto,
  • Cleison C. Lobato,
  • Sirlene S. B. Ota,
  • Franco H. A. Leite,
  • Rosivaldo S. Borges and
  • Cleydson B. R. Santos
  • + 2 authors

10 March 2020

Adenosine Receptor Type 2A (A2AAR) plays a role in important processes, such as anti-inflammatory ones. In this way, the present work aimed to search for compounds by pharmacophore-based virtual screening. The pharmacokinetic/toxicological profiles o...

  • Article
  • Open Access
28 Citations
6,051 Views
18 Pages

10 March 2020

Claims of effective therapy against diabetes using plants including Peganum harmala L., Zygophyllum album, Anacyclus valentinus L., Ammodaucus leucotrichus, Lupinus albus, and Marrubium vulgare in Algerian empirical medicine prompted our interest in...

  • Article
  • Open Access
29 Citations
4,847 Views
18 Pages

Discordant Activity of Kaempferol Towards Dengue Virus and Japanese Encephalitis Virus

  • Chit Care,
  • Wannapa Sornjai,
  • Janejira Jaratsittisin,
  • Atitaya Hitakarun,
  • Nitwara Wikan,
  • Kanokporn Triwitayakorn and
  • Duncan R. Smith

10 March 2020

Kaempferol, a plant-derived flavonoid, has been reported to have activity against Japanese encephalitis virus (JEV) in BHK-21 cells. To determine the broader utility of this compound, we initially evaluated the activity of kaempferol against JEV and...

  • Article
  • Open Access
6 Citations
4,011 Views
13 Pages

10 March 2020

This work aimed to develop accurate, quick, and practical tools for the detection of residues of penicillin G antibiotic in biological and non-biological samples. The assays were developed based on the binding mechanism of β-lactam to penicillin...

  • Feature Paper
  • Article
  • Open Access
13 Citations
3,791 Views
19 Pages

10 March 2020

Removal of Cr(VI) from the environment represents a stringent issue because of its tremendous effects on living organisms. In this context, design of sorbents with high sorption capacity for Cr(VI) is getting a strong need. For this purpose, poly(vin...

  • Article
  • Open Access
3 Citations
3,135 Views
9 Pages

Pharmacokinetics of Two Chlorine-Substituted Bis-Pyridinium Mono-Aldoximes with Regenerating Effect on Butyrylcholinesterase

  • Huba Kalász,
  • Zoltán Szimrók,
  • Gellért Karvaly,
  • Jennifer Adeghate and
  • Kornélia Tekes

10 March 2020

Our aim was to find chlorine-substituted antidotes against organophosphate poisoning and compare their pharmacokinetics to their parent compound, K-203. White male Wistar rats were intramuscularly injected with K-203, K-867 or K-870. Serum, brain, ki...

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Molecules - ISSN 1420-3049