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Special Issue "Biological Activity of Natural Substances and Their Derivatives"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 30 November 2019.

Special Issue Editors

Dr. Olga Pecháňová
E-Mail Website
Guest Editor
Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, Sienkiewiczova 1, 813 71 Bratislava, Slovakia
Interests: polyphenolic compounds; nitric oxide; cardiovascular system; hypertension; metabolic syndrome
Dr. Martina Cebova
E-Mail Website
Assistant Guest Editor
Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, Sienkiewiczova 1, 813 71 Bratislava, Slovakia
Interests: myocardial infarction; heart failure; obesity; gasotransmitters; morphological analysis

Special Issue Information

Dear Colleagues,

Although several so-called non-essential substances found in food have been shown not to be absolutely necessary to maintain basic life processes, they are useful to the human body in many critical situations and thus improve the quality of human life. Many biologically active natural substances, e.g., natural polyphenols, have a synergistic effect with different drugs, and can even alleviate the consequences of disease in pharmacotherapy intolerant individuals. In view of the current nutritional habits and prevalence of morbidity and mortality in the industrial world (cardiovascular diseases, cancer, metabolic syndrome, osteoporosis, etc.), supplements containing essential nutrients are more than desirable. In this Special Issue, we invite researchers and clinicians to contribute original research and review articles that analyze and describe new mechanisms of actions of different natural substances, and their derivatives and secondary metabolite products. Special interest is devoted to new natural products with pleiotropic effects for the prevention and treatment of cardiovascular diseases, metabolic syndrome, diabetes, nervous system disorders, inflammatory diseases, and others. Potential topics include, but are not limited to the following:

  • Preventive and curative effects of natural substances and their mechanisms of actions.
  • Pleiotropic and synergic effects of polyphenolic bioactive compounds.
    • Nanoparticles using natural substances and extracts.
    • Bioactive essential oil components: isolation, analysis, and underlying mechanisms.
    • Derivatives and secondary metabolite products.
  • Natural substances that mimic the effects of hibernation and other protective processes under extreme conditions.

Dr. Olga Pechanova
Dr. Martina Cebova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Open AccessArticle
Auriculatone Sulfate Effectively Protects Mice Against Acetaminophen-Induced Liver Injury
Molecules 2019, 24(20), 3642; https://doi.org/10.3390/molecules24203642 - 09 Oct 2019
Abstract
Acetaminophen (APAP) overdose is very common worldwide and has been widely recognized as the leading cause of drug-induced liver injury in the Western world. In our previous investigation, auriculatone, a natural product firstly obtained from Aster auriculatus, has demonstrated a potent protective [...] Read more.
Acetaminophen (APAP) overdose is very common worldwide and has been widely recognized as the leading cause of drug-induced liver injury in the Western world. In our previous investigation, auriculatone, a natural product firstly obtained from Aster auriculatus, has demonstrated a potent protective effect against APAP-induced hepatotoxicity in HL-7702 cells. However, the poor water solubility and low bioavailability restrict its application. Auriculatone sulfate (AS) is a sulfated derivative of auriculatone with highly improved water-solubility. Hepatoprotective effects against APAP-induced liver injury (AILI) showed that intragastric pretreatment with AS at 50 mg/kg almost completely prevented mice against APAP-induced increases of serum alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase and ATPase. Histological results showed that AS could protect the liver tissue damage. In addition, AS pretreatment not only significantly retained hepatic malondialdehyde and the activities of glutathione, superoxide dismutase, and glutathione peroxidase at normal levels, but also markedly suppressed the increase of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 levels in mouse liver caused by overdose APAP. Immunohistochemical analysis showed that AS obviously attenuated the expression of CD45 and HNE in liver tissue. Further mechanisms of action investigation showed that inhibition of cytochrome P450 3A11 (CYP 3A11) and CYP2E1 enzymatic activities (but not that of CYP1A2) was responsible for APAP bioactivation. In conclusion, AS showed a hepatoprotective effect against AILI through alleviating oxidative stress and inflammation and inhibiting CYP-mediated APAP bioactivation. It may be an effective hepatoprotective agent for AILI and other forms of human liver disease. Full article
(This article belongs to the Special Issue Biological Activity of Natural Substances and Their Derivatives)
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