Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates

Abo-Ghalia, Mohamed H.; Moustafa, Gaber O.; Amr, Abd El-Galil E.; Naglah, Ahmed M.; Elsayed, Elsayed A.; Bakheit, Ahmed H.

doi:10.3390/molecules25051253

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Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates

Mohamed H. Abo-Ghalia

¹,

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^1,2

^4,5

and

Ahmed H. Bakheit

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Department of Peptide Chemistry, National Research Centre, Dokki 12622, Cairo, Egypt

Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

Applied Organic Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt

⁴

Bioproducts Research Chair, Zoology Department, Faculty of Science, King Saud University, Riyadh 11451, Saudi Arabia

⁵

Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki 12622, Cairo, Egypt

⁶

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia

⁷

Department of Chemistry, Faculty of Science and Technology, El-Neelain University, PO Box 12702, Khartoum 11121, Sudan

Author to whom correspondence should be addressed.

Academic Editor: Simona Collina

Molecules 2020, 25(5), 1253; https://doi.org/10.3390/molecules25051253

Received: 21 January 2020 / Revised: 6 March 2020 / Accepted: 9 March 2020 / Published: 10 March 2020

(This article belongs to the Special Issue Recent Advances in Anticancer Drugs II)

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Abstract

As important cancer therapeutic agents, macrocyclic peptides have recently drawn great attention, mainly because they are synthetically accessible and have lower toxicity towards normal cells. In the present work, we synthesized newly macrocyclic pyridoheptapeptide derivatives. The synthesized derivatives were characterized using standard chemical and spectroscopic analytical techniques, and their anticancer activities against human breast and hepatocellular cancer cells were investigated. Results showed that compounds 1a and 1b were the most effective against hepatocellular (HepG2) and breast (MCF-7) cancer cell lines, respectively. View Full-Text

Keywords: amino acids; 3,5-tetrapeptidopyridine; macrocyclic heptapeptides; in vitro anticancer activity

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MDPI and ACS Style

Abo-Ghalia, M.H.; Moustafa, G.O.; Amr, A.E.-G.E.; Naglah, A.M.; Elsayed, E.A.; Bakheit, A.H. Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates. Molecules 2020, 25, 1253. https://doi.org/10.3390/molecules25051253

AMA Style

Abo-Ghalia MH, Moustafa GO, Amr AE-GE, Naglah AM, Elsayed EA, Bakheit AH. Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates. Molecules. 2020; 25(5):1253. https://doi.org/10.3390/molecules25051253

Chicago/Turabian Style

Abo-Ghalia, Mohamed H., Gaber O. Moustafa, Abd El-Galil E. Amr, Ahmed M. Naglah, Elsayed A. Elsayed, and Ahmed H. Bakheit. 2020. "Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates" Molecules 25, no. 5: 1253. https://doi.org/10.3390/molecules25051253

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