Special Issue "Chemistry of Antidotes"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: 31 August 2020.
Interests: toxicology; pharmacology; organosphosphates; animal experimentation; antidotes; clinical studies
Interests: analytical toxicology; pharmacology; organosphosphates; animal experimentation; antidotes; clinical studies
An antidote can be defined as a substance intended to neutralize the effects of a poison, a toxin or even a virus. To counteract the effects of a toxin or virus, vaccines are perfect examples of antidotes. In the field of toxicology, most intoxications require symptomatic management and, exceptionally, antidote treatment. In a toxicological context, certain antidotes may affect the kinetics of the toxin (toxicokinetic action), for example by modifying its absorption, distribution or elimination. On the other hand, other antidotes have a toxicodynamic action, displacing the toxin from its target (the action of flunitrazepam in benzodiazepine poisonings). Many antidotes have proved their therapeutic efficacy, such as 4-methylpyrazole for toxic alcohol poisoning, atropine for organophosphorus poisonings or metal chelators. Others have not proven with certainty their effectiveness (chloroquine and digitalis intoxication) or have a counter-action (pralidoxime and organophosphates compounds).
This Special Issue seems to me to be an opportunity to provide an update on antidotes by addressing different axes, such as the synthesis of new antidotes, new therapeutic applications, experimentation with animal and in vitro studies, etc. Finally, an analytical approach to methods of measuring antidotes in different biological matrices could complete this issue and address a topic rarely reported in the literature.
Prof. Dr. Pascal Houzé
Prof. Dr. Frédéric J. Baud
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- Analytical méthodes
- Experimental studies
- In vitro evaluation
- New compounds synthesis