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Molecules, Volume 25, Issue 4

February-2 2020 - 253 articles

Cover Story: The cyclic γ-linked tetraglutamic acids on the cover were isolated and characterized from the venom of 2 species of box jellyfish. Subsequently, they were detected in a diverse set of 8 other cnidarian species and not detectable in a sampling of species from 6 other phyla. This may be a preliminary sign that these compounds have a widespread and even unique distribution within the phylum Cnidaria, which may reflect an important but as yet undiscovered role for these cyclic peptides in the function of the cnidarian venom or its delivery system. View this paper.
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Articles (253)

  • Article
  • Open Access
34 Citations
7,275 Views
19 Pages

Phytochemical Characterization and Chemotherapeutic Potential of Cinnamomum verum Extracts on the Multiplication of Protozoan Parasites In Vitro and In Vivo

  • Gaber El-Saber Batiha,
  • Amany Magdy Beshbishy,
  • Azirwan Guswanto,
  • Arifin Nugraha,
  • Tserendorj Munkhjargal,
  • Mohamed M. Abdel-Daim,
  • Juan Mosqueda and
  • Ikuo Igarashi

24 February 2020

Cinnamomum verum is a commonly used herbal plant that has several documented properties against various diseases. The existing study evaluated the inhibitory effect of acetonic extract of C. verum (AECV) and ethyl acetate extract of C. verum (EAECV)...

  • Article
  • Open Access
12 Citations
5,266 Views
13 Pages

Direct Base-Assisted C‒H Cyclonickelation of 6-Phenyl-2,2′-bipyridine

  • Nicolas Vogt,
  • Vasily Sivchik,
  • Aaron Sandleben,
  • Gerald Hörner and
  • Axel Klein

24 February 2020

The organonickel complexes [Ni(Phbpy)X] (X = Br, OAc, CN) were obtained for the first time in a direct base-assisted arene C(sp2)–H cyclometalation reaction from the rather unreactive precursor materials NiX2 and HPhbpy (6-phenyl-2,2′-bip...

  • Article
  • Open Access
16 Citations
4,389 Views
17 Pages

Inclusion of the Phytoalexin trans-Resveratrol in Native Cyclodextrins: A Thermal, Spectroscopic, and X-Ray Structural Study

  • Laura Catenacci,
  • Milena Sorrenti,
  • Maria Cristina Bonferoni,
  • Lee Hunt and
  • Mino R. Caira

24 February 2020

The aim of the study was to determine the feasibility of complexation between the antioxidant trans-resveratrol (RSV) and underivatized cyclodextrins (CDs) using a variety of preparative methods, including physical mixing, kneading, microwave irradia...

  • Review
  • Open Access
24 Citations
16,176 Views
47 Pages

Allosteric GABAA Receptor Modulators—A Review on the Most Recent Heterocyclic Chemotypes and Their Synthetic Accessibility

  • Blanca Angelica Vega Alanis,
  • Maria Teresa Iorio,
  • Luca L. Silva,
  • Konstantina Bampali,
  • Margot Ernst,
  • Michael Schnürch and
  • Marko D. Mihovilovic

24 February 2020

GABAA receptor modulators are structurally almost as diverse as their target protein. A plethora of heterocyclic scaffolds has been described as modulating this extremely important receptor family. Some made it into clinical trials and, even on the m...

  • Article
  • Open Access
13 Citations
5,405 Views
9 Pages

Recognition of V3+/V4+/V5+ Multielectron Reactions in Na3V(PO4)2: A Potential High Energy Density Cathode for Sodium-Ion Batteries

  • Rui Liu,
  • Ziteng Liang,
  • Yuxuan Xiang,
  • Weimin Zhao,
  • Haodong Liu,
  • Yan Chen,
  • Ke An and
  • Yong Yang

24 February 2020

Na3V(PO4)2 was reported recently as a novel cathode material with high theoretical energy density for Sodium-ion batteries (SIBs). However, whether V3+/V4+/V5+ multielectron reactions can be realized during the charging process is still an open quest...

  • Article
  • Open Access
13 Citations
4,714 Views
14 Pages

24 February 2020

For large-scale bioproduction, thermal stability is a crucial property for most industrial enzymes. A new method to improve both the thermal stability and activity of enzymes is of great significance. In this work, the novel chaperones RrGroEL and Rr...

  • Review
  • Open Access
140 Citations
10,389 Views
26 Pages

Potential Use of Marine Seaweeds as Prebiotics: A Review

  • Aroa Lopez-Santamarina,
  • Jose Manuel Miranda,
  • Alicia del Carmen Mondragon,
  • Alexandre Lamas,
  • Alejandra Cardelle-Cobas,
  • Carlos Manuel Franco and
  • Alberto Cepeda

24 February 2020

Human gut microbiota plays an important role in several metabolic processes and human diseases. Various dietary factors, including complex carbohydrates, such as polysaccharides, provide abundant nutrients and substrates for microbial metabolism in t...

  • Article
  • Open Access
4 Citations
3,837 Views
15 Pages

Study on Cecropin B2 Production via Construct Bearing Intein Oligopeptide Cleavage Variants

  • Yi-Ting Fang,
  • Si-Yu Li,
  • Nien-Jen Hu,
  • Jie Yang,
  • Jyung-Hurng Liu and
  • Yung-Chuan Liu

24 February 2020

In this study, genetic engineering was applied to the overexpression of the antimicrobial peptide (AMP) cecropin B2 (cecB2). pTWIN1 vector with a chitin-binding domain (CBD) and an auto-cleavage Ssp DnaB intein (INT) was coupled to the cecB2 to form...

  • Article
  • Open Access
10 Citations
3,075 Views
10 Pages

24 February 2020

Because kaolinite includes a large range of defect elements, the effects of Mg, Fe(II), and Al doping on the CH4 adsorption and diffusion on the surface of Na-kaolinite (001) were investigated by molecular simulations. The simulation results illustra...

  • Article
  • Open Access
11 Citations
4,319 Views
15 Pages

Pharmacological Blockade of PPAR Isoforms Increases Conditioned Fear Responding in the Presence of Nociceptive Tone

  • Jessica C. Gaspar,
  • Bright N. Okine,
  • Alvaro Llorente-Berzal,
  • Michelle Roche and
  • David P. Finn

24 February 2020

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors with three isoforms (PPARα, PPARβ/δ, PPARγ) and can regulate pain, anxiety, and cognition. However, their role in conditioned fear and pain-fear interact...

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Molecules - ISSN 1420-3049Creative Common CC BY license