New Studies on the Synthesis of Biologically Active Products

Dear Colleagues,

The search for novel biologically-active substances is a major goal of medicinal chemistry, as highlighted by the emergency represented by the need for, as examples, new antibacterial or antiviral substances. Nature is very often the source of new lead compounds that constitute the starting point for the elaboration of new drugs. However, nature is sometimes miserly and substances possessing important biological activities are often obtained only in minute amounts from the natural source. In this context, synthetic organic chemists play a central role as witnessed by their incessant efforts to increase the biological effectiveness of known or new drugs through suitable structural modifications of the basic molecular architecture or to devise efficient routes to access such products in the required quantities. The construction of structurally complex molecules can be the bench test to verify the effectiveness of emerging synthetic methodologies or to discover new processes. Although this can imply a certain level of risk, synthetic plans, including new processes, intrinsically possess an added value and often contribute to the advancement of the science of organic synthesis. It is also worth highlighting that the work of synthetic chemists is increasingly supported by the close collaboration with biologists.

The purpose of this Special Issue is to gather original articles and reviews dealing with the synthesis of biologically active substances. According to the premise, synthetic studies accompanied by biological assays, or reporting new evidence on the use of known or emerging synthetic methods, would be very welcome.

Prof. Dr. Vincenzo Piccialli
Guest Editor

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