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Special Issue "Nutraceuticals: Role in Health and Disease"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 January 2020

Special Issue Editor

Guest Editor
Prof. Dr. Leticia M. Estevinho

Department of Biology and Biotechnology, School of Agriculture of the Polytechnic Institute of Bragança (ESA-IPB), Campus de Santa Apolónia, 5301-854 Bragança, Portugal
Website | E-Mail
Interests: food quality and safety; food science and technology; microbiology; biotechnology; natural products

Special Issue Information

Dear Colleagues,

The evolution of health awareness and well-being concept as well as the slowdown of the pharmaceutical industry has led to the growing demand for alternative products with benefits in human health. In recent years, the academic community and the general population have become increasingly interested in the health benefits and potential risks pertaining to beverages and food products beyond their basic nutritional assets. In their composition, functional foods have bioactive substances, “nutraceutics”, which may be classified as micronutrients (vitamins and fatty acids) and non-nutrients (phytochemicals, probiotics, and their metabolic by-products). These compounds directly or indirectly influence humans’ physiological systems, through immune–neuro–endocrine networks that help maintain homeostasis and end-organ functionality.

In this Special Issue, I invite researchers to contribute original research articles and review articles that will stimulate the continuing studies on nutraceutics. This field undoubtedly has a promising future ahead; according to estimations, by 2021 the global nutraceuticals market will have reached a value of 278.96 billion USD.

Prof. Dr. Leticia M. Estevinho
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Biological properties
  • Disease prevention
  • Functional foods
  • Nutraceuticals
  • Phytochemicals
  • Probiotics
  • Prebiotics

Published Papers (1 paper)

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Open AccessArticle
Dietary Supplementation of Vine Tea Ameliorates Glucose and Lipid Metabolic Disorder via Akt Signaling Pathway in Diabetic Rats
Molecules 2019, 24(10), 1866; https://doi.org/10.3390/molecules24101866
Received: 15 April 2019 / Revised: 9 May 2019 / Accepted: 12 May 2019 / Published: 15 May 2019
PDF Full-text (2054 KB) | HTML Full-text | XML Full-text | Supplementary Files
A traditional Chinese tea with many pharmacological effects, vine tea (VT) is considered a potential dietary supplement to improve type 2 diabetes (T2D). To investigate the effect and mechanism of VT on glucose and lipid metabolic disorders in T2D rats, Wistar rats fed [...] Read more.
A traditional Chinese tea with many pharmacological effects, vine tea (VT) is considered a potential dietary supplement to improve type 2 diabetes (T2D). To investigate the effect and mechanism of VT on glucose and lipid metabolic disorders in T2D rats, Wistar rats fed a normal diet served as the normal control, while rats fed a high-fat diet combined with low-dose streptozotocin (STZ)-induced T2D were divided into three groups: The model group (MOD); the positive control group (MET, metformin at 200 mg/kg/d); and the VT-treated group (VT500, allowed to freely drink 500 mg/L VT). After four weeks of intervention, biochemical metrics indicated that VT significantly ameliorated hyperglycemia, hyperlipidemia and hyperinsulinemia in T2D rats. Metabolomics research indicated that VT regulated the levels of metabolites closely related to glucose and lipid metabolism and promoted glycogen synthesis. Furthermore, VT had a significant influence on the expression of key genes involved in the Akt signaling pathway, inhibited gluconeogenesis through the Akt/Foxo1/Pck2 signaling pathway, and reduced fatty acid synthesis via the SREBP1c/Fasn signaling pathways. In conclusion, VT has great potential as a dietary supplement to ameliorate glucose and lipid metabolic disorders via the Akt signaling pathway in T2D rats. Full article
(This article belongs to the Special Issue Nutraceuticals: Role in Health and Disease)

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