Entropy, Volume 23, Issue 4
2021 April - 112 articles
Cover Story: T cells recognize pathogen-derived structures (antigens) through randomly recombined surface T-cell receptors (TCRs). T-cell development comprises extensive proliferation and sequential steps of quality control based on the affinity of TCRs for self-antigens, interrogated by successive interaction with antigen-presenting cells, leading to substantial cell death and, thus, generating a pool of T cells with a broad, but not self-reactive, TCR repertoire. Here, we review experimental and mathematical strategies to infer the dynamic properties of T-cell development in the thymus across multiple scales: cell cycle, population dynamics and their regulations, and how physiological T-cell development emerges from cellular interactions. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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