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22 Results Found

  • Article
  • Open Access
1 Citations
3,061 Views
17 Pages

Nisin Z Potential for the Control of Diabetic Foot Infections Promoted by Pseudomonas aeruginosa Persisters

  • Rafaela Zina,
  • Eva Cunha,
  • Isa Serrano,
  • Elisabete Silva,
  • Luís Tavares and
  • Manuela Oliveira

Diabetic foot ulcers (DFU) are a major complication of diabetes mellitus and a public health concern worldwide. The ability of P. aeruginosa to form biofilms is a key factor responsible for the chronicity of diabetic foot infections (DFIs) and freque...

  • Abstract
  • Open Access
1,156 Views
2 Pages

Antimicrobial Activity of a Bacterial Nanocellulose Film Functionalized with Nisin Z for Prospective Burn Wounds Treatment

  • Liliana Melro,
  • Tânia D. Tavares,
  • Jorge Padrão,
  • Fernando Dourado,
  • Miguel Gama,
  • Carla Silva,
  • Joana C. Antunes,
  • Helena P. Felgueiras and
  • Andrea Zille

Burn wounds can lead to numerous severe complications including bacterial infections causing patient morbidity and mortality, mostly in low- and middle-income countries. The considerable increase in microbial resistance against traditional antibiotic...

  • Article
  • Open Access
27 Citations
4,091 Views
12 Pages

11 February 2023

Diabetes mellitus (DM) patients frequently develop diabetic foot ulcers (DFU) which are generally infected by a community of microorganisms, mainly Staphylococcus aureus and Pseudomonas aeruginosa. These bacteria exhibit a multi-drug resistance profi...

  • Article
  • Open Access
1 Citations
1,999 Views
14 Pages

In Vivo Antimicrobial Activity of Nisin Z Against S. aureus and Polyurea Pharmadendrimer PUREG4OEI48 Against P. aeruginosa from Diabetic Foot Infections

  • Isa Serrano,
  • Dalila Mil-Homens,
  • Rita F. Pires,
  • Vasco D. B. Bonifácio,
  • Joana F. Guerreiro,
  • Eva Cunha,
  • Sofia S. Costa,
  • Luís Tavares and
  • Manuela Oliveira

Background/Objectives: Diabetic foot infections (DFIs) are commonly associated with frequent hospitalizations, limb amputations, and premature death due to the profile of the bacteria infecting foot ulcers. DFIs are generally colonized by a polymicro...

  • Article
  • Open Access
33 Citations
4,489 Views
21 Pages

Functionalization of Crosslinked Sodium Alginate/Gelatin Wet-Spun Porous Fibers with Nisin Z for the Inhibition of Staphylococcus aureus-Induced Infections

  • Natália C. Homem,
  • Tânia D. Tavares,
  • Catarina S. Miranda,
  • Joana C. Antunes,
  • M. Teresa P. Amorim and
  • Helena P. Felgueiras

16 February 2021

Nisin Z, an amphipathic peptide, with a significant antibacterial activity against Gram-positive bacteria and low toxicity in humans, has been studied for food preservation applications. Thus far, very little research has been done to explore its pot...

  • Article
  • Open Access
13 Citations
4,205 Views
19 Pages

Design of Lactococcus lactis Strains Producing Garvicin A and/or Garvicin Q, Either Alone or Together with Nisin A or Nisin Z and High Antimicrobial Activity against Lactococcus garvieae

  • Javier Feito,
  • Carlos Araújo,
  • Sara Arbulu,
  • Diogo Contente,
  • Beatriz Gómez-Sala,
  • Lara Díaz-Formoso,
  • Estefanía Muñoz-Atienza,
  • Juan Borrero,
  • Luis M. Cintas and
  • Pablo E. Hernández

2 March 2023

Lactococcus garvieae is a main ichthyopathogen in rainbow trout (Oncorhynchus mykiss, Walbaum) farming, although bacteriocinogenic L. garvieae with antimicrobial activity against virulent strains of this species have also been identified. Some of the...

  • Article
  • Open Access
19 Citations
3,794 Views
17 Pages

Cyclodextrin-Based Nanosponges as Perse Antimicrobial Agents Increase the Activity of Natural Antimicrobial Peptide Nisin

  • Yousef Khazaei Monfared,
  • Mohammad Mahmoudian,
  • Gjylije Hoti,
  • Fabrizio Caldera,
  • José Manuel López Nicolás,
  • Parvin Zakeri-Milani,
  • Adrián Matencio and
  • Francesco Trotta

At present, antibiotic resistance is considered a real problem. Therefore, for decades scientists have been looking for novel strategies to treat bacterial infections. Nisin Z, an antimicrobial peptide (AMP), can be considered an option, but its usag...

  • Article
  • Open Access
52 Citations
4,973 Views
19 Pages

Stabilization and Anticancer Enhancing Activity of the Peptide Nisin by Cyclodextrin-Based Nanosponges against Colon and Breast Cancer Cells

  • Yousef Khazaei Monfared,
  • Mohammad Mahmoudian,
  • Claudio Cecone,
  • Fabrizio Caldera,
  • Parvin Zakeri-Milani,
  • Adrián Matencio and
  • Francesco Trotta

1 February 2022

The great variability of cancer types demands novel drugs with broad spectrum, this is the case of Nisin, a polycyclic antibacterial peptide that recently has been considered for prevention of cancer cells growth. As an accepted food additive, this d...

  • Proceeding Paper
  • Open Access
2,448 Views
7 Pages

Lactococcus lactis RBT18: From the Rainbow Trout Farm to the Lab, the Tale of a Nisin Z Producer

  • Diogo Contente,
  • Javier Feito,
  • Juan Borrero,
  • Nuria Peña,
  • Estefanía Muñoz-Atienza,
  • Gilberto Igrejas,
  • Patrícia Poeta,
  • Pablo E. Hernández and
  • Luis M. Cintas

Infectious diseases, such as lactococcosis caused by Lactococcus garvieae, are portrayed as critical limiting factors in aquaculture. The antimicrobial properties of lactic acid bacteria (LAB), mainly the production of organic acids and bacteriocins...

  • Article
  • Open Access
1,142 Views
27 Pages

Traditional chemical-based sanitizers pose risks to health and the environment, highlighting the need for safer natural alternatives. We developed biocompatible hydrogels from carbohydrate-based biopolymers, chitosan (1.5% and 2.5%), and carboxymethy...

  • Article
  • Open Access
9 Citations
5,680 Views
16 Pages

The Influence of Intermolecular Interactions between Maleic Anhydride, Cellulose Nanocrystal, and Nisin-Z on the Structural, Thermal, and Antimicrobial Properties of Starch-PVA Plasticized Matrix

  • Taíla V. de Oliveira,
  • Pedro A. V. de Freitas,
  • Cicero C. Pola,
  • Larissa R. Terra,
  • José O. R. da Silva,
  • Amanda T. Badaró,
  • Nelson S. Junior,
  • Marciano M. de Oliveira,
  • Rafael R. A. Silva and
  • Nilda de F. F. Soares

On behalf of a circular economy, regular plastics have been replaced by biodegradable packagings. Besides, active films have been applied to improve the shelf-life and quality of foods. In this work, blends were developed using starch as a low-cost n...

  • Article
  • Open Access
8 Citations
3,239 Views
15 Pages

Suitability of the Nisin Z-producer Lactococcus lactis subsp. lactis CBM 21 to be Used as an Adjunct Culture for Squacquerone Cheese Production

  • Lorenzo Siroli,
  • Francesca Patrignani,
  • Margherita D’Alessandro,
  • Elisa Salvetti,
  • Sandra Torriani and
  • Rosalba Lanciotti

30 April 2020

This research investigated the technological and safety effects of the nisin Z producer Lactococcus lactis subsp. lactis CBM 21, tested as an adjunct culture for the making of Squacquerone cheese in a pilot-scale plant. The biocontrol agent remained...

  • Article
  • Open Access
19 Citations
6,254 Views
14 Pages

Draft Genome Sequence of Lactococcus lactis Subsp. cremoris WA2-67: A Promising Nisin-Producing Probiotic Strain Isolated from the Rearing Environment of a Spanish Rainbow Trout (Oncorhynchus mykiss, Walbaum) Farm

  • Javier Feito,
  • Diogo Contente,
  • Manuel Ponce-Alonso,
  • Lara Díaz-Formoso,
  • Carlos Araújo,
  • Nuria Peña,
  • Juan Borrero,
  • Beatriz Gómez-Sala,
  • Rosa del Campo and
  • Estefanía Muñoz-Atienza
  • + 2 authors

Probiotics are a viable alternative to traditional chemotherapy agents to control infectious diseases in aquaculture. In this regard, Lactococcus lactis subsp. cremoris WA2-67 has previously demonstrated several probiotic features, such as a strong a...

  • Article
  • Open Access
39 Citations
7,969 Views
19 Pages

Antimicrobial Potential of Food Lactic Acid Bacteria: Bioactive Peptide Decrypting from Caseins and Bacteriocin Production

  • Stefano Nebbia,
  • Cristina Lamberti,
  • Giuliana Lo Bianco,
  • Simona Cirrincione,
  • Valerie Laroute,
  • Muriel Cocaign-Bousquet,
  • Laura Cavallarin,
  • Maria Gabriella Giuffrida and
  • Enrica Pessione

Lactic acid bacteria (LAB) potential in the food industry and in the biotechnological sector is a well-established interest. LAB potential in counteracting especially food-borne infections has received growing attention, but despite being a road full...

  • Article
  • Open Access
20 Citations
4,687 Views
19 Pages

Genomic Features and Construction of Streamlined Genome Chassis of Nisin Z Producer Lactococcus lactis N8

  • Wanjin Qiao,
  • Fulu Liu,
  • Xing Wan,
  • Yu Qiao,
  • Ran Li,
  • Zhenzhou Wu,
  • Per Erik Joakim Saris,
  • Haijin Xu and
  • Mingqiang Qiao

Lactococcus lactis is a commonly used fermenting bacteria in cheese, beverages and meat products. Due to the lack of simplified chassis strains, it has not been widely used in the fields of synthetic biology. Thus, the construction of lactic acid bac...

  • Article
  • Open Access
15 Citations
5,461 Views
14 Pages

In the present study, we isolated and characterized Lactococcus lactis (L. lactis) subsp. lactis from a female Cuvier’s beaked whale (Ziphius cavirostris) stranded in Shizuoka, Japan. Only five isolates (CBW1-5), grown on Lactobacilli de Man Ro...

  • Article
  • Open Access
837 Views
23 Pages

Genome-Driven Insights into Lactococcus sp. KTH0-1S Highlights Its Biotechnological Potential as a Cell Factory

  • Nisit Watthanasakphuban,
  • Hind Abibi,
  • Nuttakan Nitayapat,
  • Phitsanu Pinmanee,
  • Chollachai Klaysubun,
  • Nattarika Chaichana,
  • Komwit Surachat and
  • Suttipun Keawsompong

25 September 2025

The safety, genetic distinctiveness, and functional capabilities of Lactococcus sp. KTH0-1S, a strain isolated from Thai fermented shrimp (Kung-Som), were investigated to assess its potential as a next-generation probiotic and microbial cell factory....

  • Article
  • Open Access
2 Citations
3,160 Views
14 Pages

Lactic Acid Bacteria (LAB) and Their Bacteriocins for Applications in Food Safety Against Listeria monocytogenes

  • Cristian Piras,
  • Alessio Soggiu,
  • Viviana Greco,
  • Pierluigi Aldo Di Ciccio,
  • Luigi Bonizzi,
  • Anna Caterina Procopio,
  • Andrea Urbani and
  • Paola Roncada

Background/Objectives: Listeria monocytogenes is a major foodborne pathogen responsible for listeriosis, a serious illness with high morbidity and mortality, particularly in vulnerable populations. Its persistence in food processing environments and...

  • Article
  • Open Access
2 Citations
2,403 Views
17 Pages

In Vitro Insights into Bacteriocin-Mediated Modulation of Chicken Cecal Microbiota

  • Amal Mamjoud,
  • Séverine Zirah,
  • Eric Biron,
  • Omar Fliss and
  • Ismail Fliss

Reducing the use of antibiotics in animal husbandry is essential to limit the spread of resistance. A promising alternative to antibiotics resides in bacteriocins, which are antimicrobial peptides produced by bacteria showing a great diversity in ter...

  • Article
  • Open Access
10 Citations
5,282 Views
15 Pages

Design of Antibacterial Agents: Alkyl Dihydroxybenzoates against Xanthomonas citri subsp. citri

  • Ana Carolina Nazaré,
  • Carlos Roberto Polaquini,
  • Lúcia Bonci Cavalca,
  • Daiane Bertholin Anselmo,
  • Marilia De Freitas Calmon Saiki,
  • Diego Alves Monteiro,
  • Aleksandra Zielinska,
  • Paula Rahal,
  • Eleni Gomes and
  • Dirk-Jan Scheffers
  • + 2 authors

6 October 2018

Xanthomonas citri subsp. citri (Xcc) causes citrus canker, affecting sweet orange-producing areas around the world. The current chemical treatment available for this disease is based on cupric compounds. For this reason, the objective of this study w...

  • Article
  • Open Access
15 Citations
3,313 Views
15 Pages

Ionic Strength of Methylcellulose-Based Films: An Alternative for Modulating Mechanical Performance and Hydrophobicity for Potential Food Packaging Application

  • Rafael Resende Assis Silva,
  • Clara Suprani Marques,
  • Tarsila Rodrigues Arruda,
  • Samiris Cocco Teixeira,
  • Taíla Veloso de Oliveira,
  • Paulo Cesar Stringheta,
  • Ana Clarissa dos Santos Pires and
  • Nilda de Fátima Ferreira Soares

The growing environmental concern with the inappropriate disposal of conventional plastics has driven the development of eco-friendly food packaging. However, the intrinsic characteristics of polymers of a renewable origin, e.g., poor mechanical prop...

  • Article
  • Open Access
6 Citations
4,406 Views
22 Pages

Metabiotics are the structural components of probiotic bacteria, functional metabolites, and/or signaling molecules with numerous beneficial properties. A novel Lactococcus lactis strain, UTNCys6-1, was isolated from wild Amazonian camu-camu fruits (...