26 Results Found

In recent years, mathematical models have developed into an important tool for cancer research, combining quantitative analysis and natural processes. We have focused on Chronic Lymphocytic Leukemia (CLL), since it is one of the most common adult leu...

Chlorambucil (Chl), Melphalan (Mel), and Cytarabine (Cyt) are recognized drugs used in the chemotherapy of patients with advanced Chronic Lymphocytic Leukemia (CLL). The optimal treatment schedule and timing of Chl, Mel, and Cyt administration remain...

This study presents a framework whereby cancer chemotherapy could be improved through collaboration between mathematicians and experimentalists. Following on from our recently published model, we use A20 murine leukemic cells transfected with monomer...

Breast cancer is one of the most widespread diseases in women worldwide. It leads to the second-largest mortality rate in women, especially in European countries. It occurs when malignant lumps that are cancerous start to grow in the breast cells. Ac...

Cancer cells typically divide with weaker synchronisation with the circadian clock than normal cells, with the degree of decoupling increasing with tumour maturity. Chronotherapy exploits this loss of synchronisation, using drugs with circadian-clock...

Acquiring sufficient data is imperative to accurately predict tumor growth dynamics and effectively treat patients. The aim of this study was to investigate the number of volume measurements necessary to predict breast tumor growth dynamics using the...

Introduction: Data are lacking on the optimal neoadjuvant systemic treatment (NST) for women with hormone receptor-positive (HR+) human epidermal growth factor receptor 2-positive (HER2+) breast cancer if they are unfit to receive the combination of...

A non-Markovian model of tumor cell invasion with finite velocity is proposed to describe the proliferation and migration dichotomy of cancer cells. The model considers transitions with age-dependent switching rates between three states: moving tumor...

Background: Respiratory failure requiring mechanical ventilation is the major reason for lung cancer patients being admitted to the intensive care unit (ICU). Though molecular targeted therapies, especially epidermal growth factor receptor (EGFR)-tyr...

Cancer, which is currently rated as the second-leading cause of mortality across the globe, is one of the most hazardous disease groups that has plagued humanity for centuries. The experiments presented here span over two decades and were conducted o...

The tumor microenvironment is a highly dynamic and complex system where cellular interactions evolve over time, influencing tumor growth, immune response, and treatment resistance. In this study, we develop a graph-theoretic framework to model the tu...

Background: This paper looks to validate the risk score from the Heart Failure Association of the European Society of Cardiology and the International Cardio-Oncology Society (HFA-ICOS) for predicting potential cardiotoxicity from anticancer therapy...

Molecular profile of breast cancer provides information about its biological activity, prognosis and treatment strategies. The purpose of our study was to investigate the correlation between ultrasound features and molecular subtypes of breast cancer...

The purpose of this study was to evaluate nationwide trends in pathologic complete response (pCR) and its racial variations for breast cancer. The National Cancer Database was queried for women from 2010 to 2017 with non-metastatic breast cancer who...

Background: Screening program effectiveness is generally evaluated for breast cancer (BC) as one disease and without considering the regularity of participation, while this might have an impact on detection rate. Objectives: To evaluate the short-ter...

Purpose: This study investigates receptor status changes following neoadjuvant chemotherapy (NAC) in breast cancer, aiming to identify new therapeutic opportunities and improve human epidermal growth factor receptor 2 (HER2) detection and categorizat...

Background: Neoadjuvant systemic therapy (NST), whose primary purposes include response assessment and treatment individualization, is a key strategy in the treatment of HER2-positive breast cancer. This study investigated the predictive value of the...

The evolution of personalized medicine has changed the therapeutic strategy from classical chemotherapy and radiotherapy to a genetic modification targeted therapy, and although biopsy is the traditional method to genetically characterize lung cancer...

Background: The pan-immune inflammation value (PIV) has unclear predictive utility for pathologic complete response (pCR) in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). This study aimed to evaluate the PIV’s predictive val...

A skin lesion is a portion of skin that observes abnormal growth compared to other areas of the skin. The ISIC 2018 lesion dataset has seven classes. A miniature dataset version of it is also available with only two classes: malignant and benign. Mal...

Activating epidermal growth factor receptor (EGFR) mutations in metastatic non-small cell lung cancer (NSCLC) are associated with a high response rate to EGFR tyrosine kinase inhibitor (TKI). The current guidelines recommend routine EGFR mutational a...

Carbonic anhydrase 9 (CA9) plays a vital role in lung cancer progression. The current study explored the effect of CA9 gene polymorphisms and the epidermal growth factor receptor (EGFR) mutations on the clinicopathological characters of lung adenocar...

Background/Objectives: Vascular endothelial growth factor (VEGF)-A promotes an immunosuppressive tumor microenvironment, potentially affecting the efficacy of anti-programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) antibody therapy...

An individual’s inherited genetic variation may contribute to the ‘angiogenic switch’, which is essential for blood supply and tumor growth of microscopic and macroscopic tumors. Polymorphisms in angiogenesis-related genes potential...

Background: Detecting molecular drivers is crucial in the management of non-small-cell lung cancer (NSCLC). This study aimed to evaluate the use of pretreatment chest computed tomography (CT) radiomics features for predicting epidermal growth factor...

Background and Objectives: Cervical cancer (CC) is a malignant tumor occurring in the cervical epithelium, which is one of the most common cancer-caused deaths in females. Inhibin β A (INHBA) is the most widely expressed biomarker of the transfo...